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Samantha Ive MIYASHIRO, Mitika Kuribayashi HAGIWARA, Leonardo Pinto BRAND�O, S�lvia Regina Ricci LUCAS

Carmustine (1,3-bis(2-chloroethyl)-1-nitrosourea; BCNU), a nitrosourea from alkylating agents group, is widely used in human medicine as an antineoplastic agent in the treatment of lymphomas and a variety of other tumors, despite of its cumulative and delayed myelosuppressor effect. Little is known about its use in dogs, specially those aspects related to bone marrow toxicity effect of the drug. Aiming to fullfil this gap, ten healthy dogs were exposed to BCNU (Day 0) in a single dose (50mg/m2) and followed by eight weeks. Physical and hematological examination were made in alternated days and bone marrow aspiration done on days 5 and 55. Biochemical profiles were performed weekly in order to observe any renal or hepatic toxicity of the drug. Leucocyte nadir occured on day 5 to day 9 (850 - 3,600 cells/mm3). Platelet number decreased mildly around day 10 (6,000 - 196,000 platelets/mm3). No red blood cell alteration was observed. Bone toxicity, otherwise human literature, was acute and severe, extremely hypocellular on day 5, with reduction of precursor cells of all series. On day 55, peripheral blood and bone marrow aspects were normal. Only mild increase in serum ALT and ALP activity was observed in three dogs, in spite of no clinical signs. Knowing the drug toxicity, specially hematologic complications which are dose-limiting, a protocol for utilization of this chemotherapic agent in dogs might be established as an alternative one in the treatment of lymphomas.

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Alternative Medicine
Animal Welfare
Clinical Pathology
Dental Congress 1:1
Dental Congress 1:2
Dental Congress 1:3
Dental Congress 2:1
Dental Congress 2:2
Dental Congress 2:3
Emergency & Critical Care
Feline Endocrine & Infectious Dz
Feline Gastroenterology
Feline Urology/Nephrology
Infectious & Zoonotic Diseases
Respiratory Medicine
Surgery & Sports Medicine
Oral Presentations
Morbidity Factors Of Anxiety Disorders
PTT Excision Of Ear Canal Polyps
Rabies Antibody Tests: IHA vs Elisa
Hip Luxation: Surgical Repair
Surgical Repair Of Mitral Regurg.
Dental Pulp/Dentin Deposition
Ehrlichiosis Study, Azarbaijans
B. Thuring. Effects On Trichostrongylus
Growth Plate Closure Times, Kangal
Revolution, Dog/Cat Flea Control
Electrical Stim. For Nerve Injuries
BAPN-F For Gastroc. Tendon Healing
Patch Test, Dogs; Human Allergy Stats.
Abd. Adhesion Prevention, Omenectomy
Leptospirosis Study, Tehran
Ehrlichiosis, Protein Alterations
Xenograft For Femural Fx. Repair
Omentum For Tendon Healing
Pet Behavior During Bombing
Evaluation Of Silk Suture
Canine Testis Gene Expression
Radiologic Signs, Spirocerca
Feline Interferon In FeLV/FIV Cats
HbA1c In Diabetic Dogs
Bovine Xenograft For Tibial Repair
Tibial Segmental Defect, Treatment
Bovine Bone Pin For Fracture Repair
Rabies Immunity, Tehran, Dogs
Oral Antibiotics, Owner Compliance
Excision Arthroplasty, Dogs/Cats
Ovine Xenograft For Radial Fractures
Endochondral Ossification
Intertrochanteric Osteotomy Fixation
Immunoglobuline, Atopic Dermatitis
Subclinical Dermatophytosis
Probiotic Strains
Efficacy of Revolution (selamectin)
Bordetella Bronchiseptica
Bone Cement and Graft
Femoral Head
Bacterial Infections, Urinary
Mammary Neoplasias
Bilateral Anterior Hemimelia
Adenocarcinoma, Apocrine Glands
You are hereBone Marrow Toxicity
Carmustine, Lymphoma
Desflurane Anesthesia
Nutrition, Hyperlipidaemia
Perianal Fistula
L-Carnitine Supplementation
Poster Presentations