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Schiessl B*, Egli K, Peel JE*, Roosje PJ, Rudaz C*, Welle M

Objectives: To establish a dog model for canine atopic dermatitis.

Design: The offspring of high IgE-responder Beagle dogs were sensitized from birth on to various allergens by repeated subcutaneous injections. Allergen specific serum IgE and IgG levels and skin testing were used as test parameters. The dogs were exposed to allergens (house dust mites) and examined weekly for clinical signs of atopic dermatitis.

Materials and Methods: Thirty eight Beagle dogs, including controls, were used for our experiments. Ovalbumine, recombinant birch pollen allergen, and house dust mite (Dermatophagoides farinae and Dermatophagoides pteronyssinus) extracts were used for subcutaneous sensitization. Cultures of the same house dust mite species were regularly spread on a carpeted bench in the kennels. Immunoglobuline levels were measured with ELISA techniques. Skin tests were performed by intracutaneous injection of the allergens and evaluated 20 minutes and 24 hours after injection.

Results: No skin disease could be provoked by subcutaneous injections, although specific immunoglobuline levels and skin test reactivity were high in sensitized (and zero in control) dogs

Conclusions: High specific IgE levels do not necessarily induce atopic dermatitis. Positive skin test reactions can be present without clinical signs. Therefore we conclude that other mechanisms are required in the pathogenesis of canine atopic dermatitis.

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Alternative Medicine
Animal Welfare
Clinical Pathology
Dental Congress 1:1
Dental Congress 1:2
Dental Congress 1:3
Dental Congress 2:1
Dental Congress 2:2
Dental Congress 2:3
Emergency & Critical Care
Feline Endocrine & Infectious Dz
Feline Gastroenterology
Feline Urology/Nephrology
Infectious & Zoonotic Diseases
Respiratory Medicine
Surgery & Sports Medicine
Oral Presentations
Morbidity Factors Of Anxiety Disorders
PTT Excision Of Ear Canal Polyps
Rabies Antibody Tests: IHA vs Elisa
Hip Luxation: Surgical Repair
Surgical Repair Of Mitral Regurg.
Dental Pulp/Dentin Deposition
Ehrlichiosis Study, Azarbaijans
B. Thuring. Effects On Trichostrongylus
Growth Plate Closure Times, Kangal
Revolution, Dog/Cat Flea Control
Electrical Stim. For Nerve Injuries
BAPN-F For Gastroc. Tendon Healing
Patch Test, Dogs; Human Allergy Stats.
Abd. Adhesion Prevention, Omenectomy
Leptospirosis Study, Tehran
Ehrlichiosis, Protein Alterations
Xenograft For Femural Fx. Repair
Omentum For Tendon Healing
Pet Behavior During Bombing
Evaluation Of Silk Suture
Canine Testis Gene Expression
Radiologic Signs, Spirocerca
Feline Interferon In FeLV/FIV Cats
HbA1c In Diabetic Dogs
Bovine Xenograft For Tibial Repair
Tibial Segmental Defect, Treatment
Bovine Bone Pin For Fracture Repair
Rabies Immunity, Tehran, Dogs
Oral Antibiotics, Owner Compliance
Excision Arthroplasty, Dogs/Cats
Ovine Xenograft For Radial Fractures
Endochondral Ossification
Intertrochanteric Osteotomy Fixation
You are hereImmunoglobuline, Atopic Dermatitis
Subclinical Dermatophytosis
Probiotic Strains
Efficacy of Revolution (selamectin)
Bordetella Bronchiseptica
Bone Cement and Graft
Femoral Head
Bacterial Infections, Urinary
Mammary Neoplasias
Bilateral Anterior Hemimelia
Adenocarcinoma, Apocrine Glands
Bone Marrow Toxicity
Carmustine, Lymphoma
Desflurane Anesthesia
Nutrition, Hyperlipidaemia
Perianal Fistula
L-Carnitine Supplementation
Poster Presentations