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Fig. 1: Serum protein electrophoresis SDS PAGE gel - serum sample from a cat with non-cutaneous extramedullary plasmacytoma (an hepatic MRD).
	Fig. 2: Densitometry trace of the same serum protein electrophoresis gel seen in Fig. 1. This cat has a classical tall monoclonal spike (right side of the trace) consistent with a monoclonal paraproteinaemia. 83% of cats showed a monoclonal paraprotein spike in one series.
	Fig. 3: Serum protein electrophoresis demonstrates a small but narrow spike in the gamma-globulin region, five years after the initial histopathological diagnosis of solitary plasmacytoma of bone in this cat. Although the absolute concentration of the gamma-globulin fraction is within normal limits (25.63g/L, reference range 17 - 27g/L), the spike is consistent with a low concentration paraproteinaemia. (Case 2, (Mellor et al 2007b)) (copyright Journal of Feline Medicine and Surgery, Elsevier).
	Fig. 4: Urine protein electrophoresis densitometry trace from a cat with MRD displaying biclonality. 17% of cats showed biclonality in one study (Mellor et al 2006). Biclonality is a recognised phenomenon and is likely to be attributable to the development of 2 neoplastic clones or isotype switching of some clones (Larsen and Carpenter 1994, Bienzle et al 2000, Yoshida et al 2004).