Vet Clinical Trials

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Vet Clinical Trials

Dogs
System
Gastrointestinal
Identification of Genetic Risk in Shetland Sheepdogs with Gallbladder Mucocele Formation
December 4, 2023

The long term goal of this research is to determine which gene(s) are responsible for predisposition of Shetland sheepdogs to mucocele formation. This will enable a better understanding of pathogenesis of mucocele formation in this breed.
Dr. Gookin is looking for Shetland Sheepdogs with gallbladder mucocele. See the trial page for specific information on eligibility.
Risk Factors for Nutritionally-mediated DCM in Healthy Dogs of 2 Size Groups: The Role of Diet Category, Taurine, Cardiac Biomarkers, and Metabolomics
February 19, 2024

We hope to identify differences in cardiac parameters related to diet and/or breed size, and to investigate underlying factors that may be related to those differences.
Drs Larsen and Stern are looking for dogs fed “grain free” diets.
Developmental
Genetic Mapping of Legg Calve Perthes Disease
August 4, 2015

Legg Calve Perthes Disease (avascular necrosis of the femoral head) affects dogs. A genetic basis is suspected.
Dr Todhunter is looking for dogs with Legg Calve Perthes Disease.
See the trial page for specific information on eligibility.
Digestive
Granulomatous Disease
January 7, 2015

Search For A Dog With X-Linked Chronic Granulomatous Disease
Drs. Harry Malech and Sebastian Brenner
Examples of canine patients that may be of value to them are young Weimaraners with recurrent infection secondary to suspected neutrophil dysfunction, or young dogs from other breeds with a history of chronic recurring infections, particularly with organisms such as Aspergillus, Staphylococcus, Serratia or Burkholderia cepacia.
Prospective evaluation of a minimally invasive treatment option for extrahepatic biliary duct obstructions (EHBDO) in dogs and cats
January 14, 2015

This FULLY FUNDED study evaluates the treatment for extra hepatic biliary duct obstruction (EHBDO) in dogs and cats using endoscopy and retrograde stenting to improve the morbidity and mortality.
Dr Berent is looking for dogs and cats with biliary obstructions. See the trial page for specific information on eligibility.
Endocrine
Incidence, Prevalence, and Genetics of Canine Diabetes
May 15, 2017

The survey hopes to use this data to investigate the prevalence, incidence, and potentially mode of inheritance of diabetes mellitus in dogs at increased risk for the disease, as well as that of the general population and those at decreased risk.
Dr Cai is looking for dogs with and without diabetes mellitus.
See the trial page for specific information on eligibility.
Musculoskeletal
Genetic Mapping of Legg Calve Perthes Disease
August 4, 2015

Legg Calve Perthes Disease (avascular necrosis of the femoral head) affects dogs. A genetic basis is suspected.
Dr Todhunter is looking for dogs with Legg Calve Perthes Disease.
See the trial page for specific information on eligibility.
Hereditary Evaluation of Legg-Calve-Perthes Disease in Toy and Miniature Breeds
November 3, 2008

Legg-Calve-Perthes Disease (LCPD) is a developmental disorder affecting the hip joint of small-breed puppies. Our study aims to identify (1) the mode of inheritance of LCPD in several small breeds and (2) candidate genes that may either cause the disease or be involved in the disease process through whole-genome association mapping.
Dr Starr
is looking for dogs with Legg-Calve-Perthes disease. See the trial page for specific information on eligibility.
Hypertrophic Osteodystrophy (HOD): Identifying the Genes Responsible
December 31, 2013

This study aims to identify the molecular cause for hypertrophic osteodystrophy. HOD is a familial disorder with an unknown etiology.
Dr Safra
is looking for dogs with hypertrophic osteodystrophy. See the trial page for specific information on eligibility.
The Use of a Minimally Invasive Integrated Endoscopic System to Perform Hemilaminectomies in Chondrodystrophic Dogs with Thoracolumbar Intervertebral Disc Extrusions
December 28, 2020

To evaluate the use of a minimally invasive approach to perform hemilaminectomies in certain dogs with intervertebral disc herniations. A secondary goal is to compare the MIS hemilaminectomy to the standard approach. Where available, the long-term outcome of patients will also be included.
Dr Bartner is looking for chondrodystrophic dogs (e.g. Dachshunds) with acute thoracolumbar disc disease requiring surgery. See the trial page for specific information on eligibility.
Neurological
Epilepsy Research
October 1, 2002

Canine Epilepsy Research Consortium is studying the genetics of epilepsy in all purebred dogs
To ensure the success of the study Dr. Ned Patterson, DVM from the Canine Genetics Lab, Department of Small Animal Clinical Sciences wants to obtain DNA samples and health information from more families (including siblings, parents, grandparents, offspring or distant relatives) in which one or more members has epilepsy.
Dogs or dogs with a family history of epilepsy are needed.
Hereditary evaluation of spina bifida and cleft palate in brachycephalic dogs
January 20, 2009

We hope to identify candidate genes associated with canine structural birth defects, specifically spina bifida and cleft lip/palate in the bulldog and other brachycephalic breeds. This would allow us to develop a genetic test that could identify affected dogs and carrier dogs.
Dr Starr
is looking for Bulldogs or brachycephalic dogs with spina bifida or labio-palatine closure defects. See the trial page for specific information on eligibility.
Identification of Genetic Risk in Collies and Shetland Sheepdogs with Epilepsy
July 20, 2022

Objectives: 1. Conduct a genome-wide association study (GWAS) to identify genomic regions associated with epilepsy in collies and shetland sheepdogs 2. Generate whole genome resequencing data to identify putative causal variants in associated regions.
Dr Clark is looking for Collies and Shetland Sheep dogs with epilepsy. See the trial page for specific information on eligibility.
The Use of a Minimally Invasive Integrated Endoscopic System to Perform Hemilaminectomies in Chondrodystrophic Dogs with Thoracolumbar Intervertebral Disc Extrusions
December 28, 2020

To evaluate the use of a minimally invasive approach to perform hemilaminectomies in certain dogs with intervertebral disc herniations. A secondary goal is to compare the MIS hemilaminectomy to the standard approach. Where available, the long-term outcome of patients will also be included.
Dr Bartner is looking for chondrodystrophic dogs (e.g. Dachshunds) with acute thoracolumbar disc disease requiring surgery. See the trial page for specific information on eligibility.
Respiratory
Skin
Measurement of IL-31 Levels in Dogs with Cutaneous Epitheliotropic T Cell Lymphoma: Its Association with Pruritus and the use of Lokivetmab (Cytopoint) as an Antipruritic Treatment
September 10, 2021

Humans as well as dogs with cutaneous epitheliotropic T cell lymphoma (CETL) often suffer from intense itchiness which can cause significant discomfort and can affect quality of life. Can this itchiness be controlled with Cytopoint?
Dr Souza is looking for dogs with epitheliotropic T-cell Lymphoma. See the trial page for specific information on eligibility.
Transcriptome Profiling of Canine Familial Dermatomyositis (DMS) Skin Lesions and Treatment in Collies and Shetland sheepdogs
July 20, 2022

To evaluate the molecular signature of canine familial DMS using RNA sequencing in Collies and Shelties.
Dr Banovic is looking for Collies and Shelties with cutaneous dermatomyositis. See the trial page for specific information on eligibility.
Urinary
Use of Canine Struvite Dissolution Diet in the Management of Infection Induced Struvite Stones in Dogs
August 30, 2017

We hope to provide another effective dietary option to struvite dissolution in dogs. By feeding the test diet (brand blinded to client) and antibiotics we expect that dissolution of canine struvite bladder stones will occur within a 12-week period.
Dr Westropp is looking for dogs with struvite uroliths.
See the trial page for specific information on eligibility.
Disease
Degenerative
Genetic Mapping of Legg Calve Perthes Disease
August 4, 2015

Legg Calve Perthes Disease (avascular necrosis of the femoral head) affects dogs. A genetic basis is suspected.
Dr Todhunter is looking for dogs with Legg Calve Perthes Disease.
See the trial page for specific information on eligibility.
Hereditary Evaluation of Legg-Calve-Perthes Disease in Toy and Miniature Breeds
November 3, 2008

Legg-Calve-Perthes Disease (LCPD) is a developmental disorder affecting the hip joint of small-breed puppies. Our study aims to identify (1) the mode of inheritance of LCPD in several small breeds and (2) candidate genes that may either cause the disease or be involved in the disease process through whole-genome association mapping.
Dr Starr
is looking for dogs with Legg-Calve-Perthes disease. See the trial page for specific information on eligibility.
Incidence, Prevalence, and Genetics of Canine Diabetes
May 15, 2017

The survey hopes to use this data to investigate the prevalence, incidence, and potentially mode of inheritance of diabetes mellitus in dogs at increased risk for the disease, as well as that of the general population and those at decreased risk.
Dr Cai is looking for dogs with and without diabetes mellitus.
See the trial page for specific information on eligibility.
Prospective randomized clinical trial of doxepin in canine laryngeal paralysis
February 4, 2016

This placebo controlled randomized clinical trial will evaluate the efficacy of doxepin in the treatment of non-critical laryngeal paralysis in Labrador Retrievers.
Dr Rishniw is looking for Labrador Retrievers with laryngeal paralysis.
See the trial page for specific information on eligibility.
Developmental
Hereditary evaluation of spina bifida and cleft palate in brachycephalic dogs
January 20, 2009

We hope to identify candidate genes associated with canine structural birth defects, specifically spina bifida and cleft lip/palate in the bulldog and other brachycephalic breeds. This would allow us to develop a genetic test that could identify affected dogs and carrier dogs.
Dr Starr
is looking for Bulldogs or brachycephalic dogs with spina bifida or labio-palatine closure defects. See the trial page for specific information on eligibility.
Genetic
Granulomatous Disease
January 7, 2015

Search For A Dog With X-Linked Chronic Granulomatous Disease
Drs. Harry Malech and Sebastian Brenner
Examples of canine patients that may be of value to them are young Weimaraners with recurrent infection secondary to suspected neutrophil dysfunction, or young dogs from other breeds with a history of chronic recurring infections, particularly with organisms such as Aspergillus, Staphylococcus, Serratia or Burkholderia cepacia.
Hereditary Evaluation of Legg-Calve-Perthes Disease in Toy and Miniature Breeds
November 3, 2008

Legg-Calve-Perthes Disease (LCPD) is a developmental disorder affecting the hip joint of small-breed puppies. Our study aims to identify (1) the mode of inheritance of LCPD in several small breeds and (2) candidate genes that may either cause the disease or be involved in the disease process through whole-genome association mapping.
Dr Starr
is looking for dogs with Legg-Calve-Perthes disease. See the trial page for specific information on eligibility.
Hereditary evaluation of spina bifida and cleft palate in brachycephalic dogs
January 20, 2009

We hope to identify candidate genes associated with canine structural birth defects, specifically spina bifida and cleft lip/palate in the bulldog and other brachycephalic breeds. This would allow us to develop a genetic test that could identify affected dogs and carrier dogs.
Dr Starr
is looking for Bulldogs or brachycephalic dogs with spina bifida or labio-palatine closure defects. See the trial page for specific information on eligibility.
Hypertrophic Osteodystrophy (HOD): Identifying the Genes Responsible
December 31, 2013

This study aims to identify the molecular cause for hypertrophic osteodystrophy. HOD is a familial disorder with an unknown etiology.
Dr Safra
is looking for dogs with hypertrophic osteodystrophy. See the trial page for specific information on eligibility.
Identification of Genetic Risk in Collies and Shetland Sheepdogs with Epilepsy
July 20, 2022

Objectives: 1. Conduct a genome-wide association study (GWAS) to identify genomic regions associated with epilepsy in collies and shetland sheepdogs 2. Generate whole genome resequencing data to identify putative causal variants in associated regions.
Dr Clark is looking for Collies and Shetland Sheep dogs with epilepsy. See the trial page for specific information on eligibility.
Molecular mapping and characterization of the genetic modifier associated with Collie Eye Anomaly (CEA) and Colobomas
July 19, 2022

To determine genetic modifiers contributing to Coloboma formation in collies
Dr Aguirre is looking for Collies with colobomas. See the trial page for specific information on eligibility.
Risk Factors for Nutritionally-mediated DCM in Healthy Dogs of 2 Size Groups: The Role of Diet Category, Taurine, Cardiac Biomarkers, and Metabolomics
February 19, 2024

We hope to identify differences in cardiac parameters related to diet and/or breed size, and to investigate underlying factors that may be related to those differences.
Drs Larsen and Stern are looking for dogs fed “grain free” diets.
Inflammatory/Infectious
Granulomatous Disease
January 7, 2015

Search For A Dog With X-Linked Chronic Granulomatous Disease
Drs. Harry Malech and Sebastian Brenner
Examples of canine patients that may be of value to them are young Weimaraners with recurrent infection secondary to suspected neutrophil dysfunction, or young dogs from other breeds with a history of chronic recurring infections, particularly with organisms such as Aspergillus, Staphylococcus, Serratia or Burkholderia cepacia.
Transcriptome Profiling of Canine Familial Dermatomyositis (DMS) Skin Lesions and Treatment in Collies and Shetland sheepdogs
July 20, 2022

To evaluate the molecular signature of canine familial DMS using RNA sequencing in Collies and Shelties.
Dr Banovic is looking for Collies and Shelties with cutaneous dermatomyositis. See the trial page for specific information on eligibility.
Use of Canine Struvite Dissolution Diet in the Management of Infection Induced Struvite Stones in Dogs
August 30, 2017

We hope to provide another effective dietary option to struvite dissolution in dogs. By feeding the test diet (brand blinded to client) and antibiotics we expect that dissolution of canine struvite bladder stones will occur within a 12-week period.
Dr Westropp is looking for dogs with struvite uroliths.
See the trial page for specific information on eligibility.
Neoplastic
Canine Mammary Tumors: Time to Second Tumor Investigation
June 7, 2006

This study aims to delineate the median time from first mammary gland tumor in a dog to the second mammary gland tumor as a baseline for future mammary tumor chemoprevention trials.
Dr Phil Bergman
is looking for dogs that have had mammary tumor recurrence. All information is submitted via the survey form on the trial page.
Contrast Enhanced Imaged Guided Surgery for Cancer
October 28, 2011

We hope to determine if a novel imaging system accurately delineates tumors and their margins during surgery.
Dr Holt
is looking for dogs with primary lung tumors, mammary tumors or soft-tissue sarcomas amenable to surgical resection. See the trial page for specific information on eligibility.
Neoplastic
Measurement of IL-31 Levels in Dogs with Cutaneous Epitheliotropic T Cell Lymphoma: Its Association with Pruritus and the use of Lokivetmab (Cytopoint) as an Antipruritic Treatment
September 10, 2021

Humans as well as dogs with cutaneous epitheliotropic T cell lymphoma (CETL) often suffer from intense itchiness which can cause significant discomfort and can affect quality of life. Can this itchiness be controlled with Cytopoint?
Dr Souza is looking for dogs with epitheliotropic T-cell Lymphoma. See the trial page for specific information on eligibility.
Nutrtition
Use of Canine Struvite Dissolution Diet in the Management of Infection Induced Struvite Stones in Dogs
August 30, 2017

We hope to provide another effective dietary option to struvite dissolution in dogs. By feeding the test diet (brand blinded to client) and antibiotics we expect that dissolution of canine struvite bladder stones will occur within a 12-week period.
Dr Westropp is looking for dogs with struvite uroliths.
See the trial page for specific information on eligibility.
Toxic
Other
Identification of Genetic Risk in Shetland Sheepdogs with Gallbladder Mucocele Formation
December 4, 2023

The long term goal of this research is to determine which gene(s) are responsible for predisposition of Shetland sheepdogs to mucocele formation. This will enable a better understanding of pathogenesis of mucocele formation in this breed.
Dr. Gookin is looking for Shetland Sheepdogs with gallbladder mucocele. See the trial page for specific information on eligibility.
Prospective evaluation of a minimally invasive treatment option for extrahepatic biliary duct obstructions (EHBDO) in dogs and cats
January 14, 2015

This FULLY FUNDED study evaluates the treatment for extra hepatic biliary duct obstruction (EHBDO) in dogs and cats using endoscopy and retrograde stenting to improve the morbidity and mortality.
Dr Berent is looking for dogs and cats with biliary obstructions. See the trial page for specific information on eligibility.
Miscellaneous
Cannabinoid Therapeutic Drug Monitoring
August 23, 2017

We are surveying plasma cannabinoid concentrations in dogs or cats that are receiving any type of cannabinoid-based product. Part of the submission process is also completing a survey that can provide evidence/guidance regarding therapeutic response such that a plasma cannabinoid/response relationship can be built.
Dr Boothe is looking for dogs or cats that have been treated with cannabinoid products.
See the trial page for specific information on eligibility.
Cats
System
Cardiovascular
Feline Cardiomyopathy Consortium
October 25, 2011

The major objective of the consortium is to elucidate the genetic mutations that are directly causative and or increase the risk for developing feline heart disease, with the goal of eradicating and or monitoring the mutations within the cat populations via genetic testing and clinical evaluations.
Dr Haggstrom
is looking for cats with cardiomyopathy. See the trial page for specific information on eligibility.
Study of the Utility of Rivaroxaban or Clopidogrel for prevention of recurrent Arterial Thromboembolism in cats (SUPERCAT)
February 3, 2020

The SUPER-CAT trial compares clopidogrel to rivaroxaban for prevention of cardiogenic thromboembolism in cats that have experienced and recovered from a cardiogenic thromboembolism.
Dr Brainard is looking for cats with aortic thromboembolism (saddle thrombus).
See the trial page for specific information on eligibility.
Digestive
Prospective evaluation of a minimally invasive treatment option for extrahepatic biliary duct obstructions (EHBDO) in dogs and cats
January 14, 2015

This FULLY FUNDED study evaluates the treatment for extra hepatic biliary duct obstruction (EHBDO) in dogs and cats using endoscopy and retrograde stenting to improve the morbidity and mortality.
Dr Berent is looking for dogs and cats with biliary obstructions. See the trial page for specific information on eligibility.
Endocrine
Genetic Mapping of Diabetes Mellitus in the Cat
August 17, 2022

We need help to replicate/confirm a genetic locus(i) for diabetes mellitus in cats that can be used to better understand its genetic etiology and develop marker panels to identify susceptible cats.
Dr. Hayward is looking for cats with diabetes mellitus. See the trial page for specific information on eligibility.
The CATPAD study: Evaluation of markers of pancreatic disease in cats before and after switching to a special diet for kidney disease or diabetes mellitus
October 4, 2024

We hope to identify the nutrients that are associated with elevated pancreatic-specific serum markers in cats, which suggest pancreatic cell damage. And hence better understand what nutrient might possibly cause or aggravate pancreatitis and thus should be avoided in cats with or at risk of pancreatitis. See https://vetmed.tamu.edu/gilab/research/catpad-study/ for more information.
Dr. Wu is looking for cats with either chronic kidney disease or diabetes mellitus.
Gastrointestinal
The CATPAD study: Evaluation of markers of pancreatic disease in cats before and after switching to a special diet for kidney disease or diabetes mellitus
October 4, 2024

We hope to identify the nutrients that are associated with elevated pancreatic-specific serum markers in cats, which suggest pancreatic cell damage. And hence better understand what nutrient might possibly cause or aggravate pancreatitis and thus should be avoided in cats with or at risk of pancreatitis. See https://vetmed.tamu.edu/gilab/research/catpad-study/ for more information.
Dr. Wu is looking for cats with either chronic kidney disease or diabetes mellitus.
Disease
Genetic
Genetic Mapping of Diabetes Mellitus in the Cat
August 17, 2022

We need help to replicate/confirm a genetic locus(i) for diabetes mellitus in cats that can be used to better understand its genetic etiology and develop marker panels to identify susceptible cats.
Dr. Hayward is looking for cats with diabetes mellitus. See the trial page for specific information on eligibility.
Inflammatory/Infectious
Feline Vector-Borne Disease (FVBD) in Cats with Acute Onset Fever
June 30, 2015

We will use recently improved vector-borne pathogen diagnostic assays to screen cats with acute onset fever to gain insight into the prevalence of feline vector-borne diseases in cats with acute onset fever and to better understand the clinical signs of diseases caused by flea and tick-borne pathogens.
Dr Qurollo is looking for cats with sudden onset fevers. See the trial page for specific information on eligibility.
Toxic
Other
Prospective evaluation of a minimally invasive treatment option for extrahepatic biliary duct obstructions (EHBDO) in dogs and cats
January 14, 2015

This FULLY FUNDED study evaluates the treatment for extra hepatic biliary duct obstruction (EHBDO) in dogs and cats using endoscopy and retrograde stenting to improve the morbidity and mortality.
Dr Berent is looking for dogs and cats with biliary obstructions. See the trial page for specific information on eligibility.
Study of the Utility of Rivaroxaban or Clopidogrel for prevention of recurrent Arterial Thromboembolism in cats (SUPERCAT)
February 3, 2020

The SUPER-CAT trial compares clopidogrel to rivaroxaban for prevention of cardiogenic thromboembolism in cats that have experienced and recovered from a cardiogenic thromboembolism.
Dr Brainard is looking for cats with aortic thromboembolism (saddle thrombus).
See the trial page for specific information on eligibility.
Miscellaneous
Cannabinoid Therapeutic Drug Monitoring
August 23, 2017

We are surveying plasma cannabinoid concentrations in dogs or cats that are receiving any type of cannabinoid-based product. Part of the submission process is also completing a survey that can provide evidence/guidance regarding therapeutic response such that a plasma cannabinoid/response relationship can be built.
Dr Boothe is looking for dogs or cats that have been treated with cannabinoid products.
See the trial page for specific information on eligibility.
Other Animals
Exotic Tumor Database
February 21, 2017

The Exotic Tumor Database will combine cases from multiple institutions to obtain statistically significant information on treatment outcomes for non-domestic species with cancer. This information can help clinicians guide therapy as well as guide researchers to develop clinical trials.
Drs Zehnder and Harrison are looking for any exotic animal species with a histologically diagnosed tumor.
See the trial page for specific information on eligibility.
Grey Parrot Anatomy Project
July 1, 2013

There are no good anatomical references for grey parrots. This project hopes to create a digital atlas of Grey Parrot anatomy.
Dr. Speer
is looking for Grey Parrot cadavers or birds about to be euthanized. See the trial page for specific information on eligibility.

Outcomes of Surgical Management of Horses Undergoing Ventral Midline Celiotomy for Colic with Abnormalities of the Dorsal Mesenteric Attachments of the Colon and Cecum
December 26, 2020

The investigators are seeking post-operative colic cases that have elongated dorsal mesenteric attachments of the cecum and colon associated with presence of a large colon displacement or volvulus. Short and long-term outcomes assessments of these cases compared with controls is requested.
Dr Hassel is looking for horses that have undergone colic surgery
See the trial page for specific information on eligibility.

Seasonal Pasture Myopathy in Horses
October 21, 2011

Our goal is to work with veterinarians and horse owners to identify which horses are at risk and to find the best diagnostic test for this condition.
Dr Valberg
is looking for horses with suspected SPM. See the trial page for specific information on eligibility.

Closed Trials

Closed

Cats

Active, Not Recruiting

Dogs

Chronic Hepatitis in Standard Poodles (Study Closed)
July 27, 2012

To characterize chronic hepatitis in the Standard Poodle using clinical, laboratory and histopathologic findings.
Dr Bradley
is looking for Standard Poodles with chronic hepatitis. See the trial page for specific information on eligibility.

Conditionally Licensed Monoclonal Antibody Multi-agent Chemotherapy for Dogs with T-Cell Lymphoma (Study Closed)
October 1, 2014

ACI is currently enrolling cases in a nationwide clinical trial to evaluate a monoclonal antibody (AT-005) that is conditionally licensed by the USDA to aid in the treatment of dogs with lymphoma. The study is designed to assess the benefit of adding AT-005 to a multi-agent chemotherapy protocol for dogs with intermediate to high grade T-cell lymphoma.
Dr Johannes
is looking for dogs with T-cell lymphoma. See the trial page for specific information on eligibility.

Conditionally Licensed Monoclonal Antibody + CCNU Chemotherapy for Dogs with T-Cell Lymphoma (Study Closed)
October 17, 2014

ACI is currently enrolling cases in a nationwide clinical trial to evaluate a monoclonal antibody (AT-005) that is conditionally licensed by the USDA to aid in the treatment of dogs with lymphoma. The study is designed to assess the benefit of adding a T-cell-specific monoclonal antibody to a single agent CCNU chemotherapy protocol for dogs with intermediate to high grade T-cell lymphoma.
Dr Johannes is looking for dogs with T-cell lymphoma. See the trial page for information on eligibility

Effects of Cyclosporine on Activated T-Cell Expression of IL-2 and IFN-gamma in Dogs (Study Closed)
May 16, 2016

We hope to establish baseline (pre-treatment) levels of activated T-cell expression of IL-2 and IFN-gamma in dogs with anal furunculosis. These baseline values will help us to interpret results using the same assay from dogs with anal furunculosis that are receiving cyclosporine.
Dr Mackin is looking for dogs with anal furunculosis.
See the trial page for specific information on eligibility.

Evaluation of Listeria monocytogenes expressing recombinant huHer2/neu to stimulate anti-tumor immunity and prolong survival times in dogs with appendicular osteosarcoma (Study Closed)
November 1, 2011

The goal of the work is to determine a safe and effective dose of recombinant Listeria monocytogenes that induces Her-2/neu specific T cell immune responses in dogs with appendicular OSA. In addition we hope to determine whether this vaccine can prolong disease free interval and overall survival in dogs with Her-2/neu expressing OSA.
Dr Mason
is looking for dogs with osteosarcoma. See the trial page for specific information on eligibility.

Genetic Cause of Patent Ductus Arteriosus (PDA) in Pembroke Welsh Corgis (Study Closed)
January 17, 2012

Our goal is to be able to identify the genetic cause of the PDA in Corgis in order to improve the health of the breed and also to further our understanding of human PDAs.
Dr Freeman
Dr Freeman

NBD peptide as an adjunct therapy for the treatment of canine diffuse large B cell lymphoma (Study Closed)
November 1, 2011

This study hopes to find a safe, biologically effective dose of NBD peptide that inhibits constitutive NF-kappaB activity in the malignant B cells of dogs with diffuse large B cell lymphoma.
Dr Mason
is looking for dogs with lymphoma. See the trial page for specific information on eligibility.

Complete

Cats

Calcium Oxalate Urolithiasis in Dogs (Study Closed)
January 25, 2007

Cat Litter Additive And Diabetes Trial - (Trial Ended)
August 31, 2000

Cat litter additive and diabetesSusan McDonough, VMD Cats with diabetes needed.

Clinical Research on Serum Markers for Feline Enteropathies (Study Closed)
June 18, 2010

We hope to find non-invasive markers of feline enteric disease.
Dr Craven
is looking for cats with IBD or intestinal lymphoma. See the trial page for specific information on eligibility.

Diarrhea in Puppies and Kittens (Study Closed)
March 10, 2004

Chronic canine and feline diarrhea
Puppies and kittens that have chronic diarrhea and that have had an initial medical work-up to rule out identifiable causes of chronic diarrhea will be eligible to enroll.
Puppies or Kittens with chronic diarrhea needed.

Evaluation of Calcium Metabolism and Urinary Saturation in Cats (Study Closed)
January 25, 2007

Feline Aortic Thromboembolism: Clopidogrel vs Aspirin Trial: FATCAT (Study Closed)
October 10, 2006

The purpose of this study is to determine whether Plavix (clopidogrel) decreases recurrence of thromboembolism in cats compared to aspirin.
Dr. Dan Hogan
is looking for cats with documented evidence of thromboembolism that have survived at least 1 month beyond the acute event.

Feline Oral Squamous Cell Carcinoma (Study Closed)
December 2, 2004

Immunophenotyping Feline Myeloma-related Disorders
February 12, 2008

National Feline Abscess/Bite Wound Retroviral Prevalence Study (Study Closed)
April 9, 2007

Phase II Evaluation of Oral Docetaxel in Cats with Carcinomas (Study Closed)
August 2, 2008

This study aims to determine whether or not orally administered docetaxel is an effective chemotherapy treatment for cats with various carcinomas, with an emphasis on oral squamous cell carcinoma.
Dr Margaret McEntee
is looking for cats with various carcinomas, focusing on oral carcinoma. See the trial page for specific information on eligibility.

Prosaptide^(TM) TX14(A) in Feline Diabetic Neuropathy (Study Closed)
August 13, 2007

Risk Factors for Cats with Idiopathic Hypercalcemia (Study Closed)
August 11, 2006

Role of Feline Tritrichomonas foetus in Venereal Infection (Study Closed)
November 1, 2007

Serological Investigation of Cuterebra Larval Migration as a Cause of Neurologic Disease in Cats - (Project Ended)
August 24, 2000

Serological Investigation of Cuterebra Larval Migration as a Cause of Neurologic Disease in Cats.Andrew Mackin, Mississippi State University Serum samples and larvae needed from cats with Cuterebra myiasis.

Transdermal Gel Drug Absorption in Dogs and Cats (Study Closed)
June 9, 2006

Transdermal vs Oral Amitriptyline in Cats (Multiple Dose Testing) (Study Closed)
June 21, 2004

Vaccine-Associated Feline Sarcoma (Study Suspended)
July 6, 2004

West Nile Virus Update - (Study ended)
August 28, 2002

Dogs

Calcium Oxalate Urolithiasis in Dogs (Study Closed)
January 25, 2007

Canine Azathioprine Project - (Trial Ended)
August 5, 2002

Canine Blood Typing and Compatibility of Transfused Dogs (Study Closed)
July 28, 2015

We are offering Dal and quantitative DEA 1 typing and crossmatching to detect post-transfusion alloantibodies and potentially compatible donors.
Dr Giger is looking for dogs that have had blood transfusions. See the trial page for specific information on eligibility.

Clinical Study of Improved Management of Advanced Kidney Disease in Dogs Using an Intestinal-based probiotic
August 6, 2007

Clinical Trial on Canine Transitional Cell Carcinoma (Study Closed)
December 2, 2004

Description and Characterization of a Hair Coat Disorder in Schipperkes (Study Closed)
September 25, 2008

Hair coat disorders in Schipperkes have not been extensively characterized. To further investigate Alopecia X in plush-coated breeds, six healthy, unaffected Schipperke dogs and 12 Schipperke dogs with a history of symmetrical non-inflammatory alopecia will be entered into the study to determine if the condition in the Schipperke is similar to that in other breeds.
Dr May
is looking for Schipperkes with alopecia. See the trial page for specific information on eligibility.

Diarrhea Clinical Study - (Study Ended)
September 4, 2002

Diarrhea in Puppies and Kittens (Study Closed)
March 10, 2004

Chronic canine and feline diarrhea
Puppies and kittens that have chronic diarrhea and that have had an initial medical work-up to rule out identifiable causes of chronic diarrhea will be eligible to enroll.
Puppies or Kittens with chronic diarrhea needed.

Drug Toxicity (Study Closed)
August 18, 2003

Evaluation of a new diet for managing Dalmatians that have had urate bladder stones (Study Closed)
January 25, 2007

Evaluation of an alternative method for dissolving infection-induced struvite stones in dogs (Study Closed)
January 25, 2007

Evaluation of Fatty Acid Supplementation in Dogs with Severe Pulmonic Stenosis (Study Closed)
February 4, 2009

Genetic markers for Diabetes Mellitus in Samoyed and Australian Terrier dogs (Study Closed)
November 6, 2006

This study hopes to find genes that increase the risk for diabetes mellitus in Samoyed and Australian Terrier dogs. Early genetic identification of carriers and dogs that are likely to develop diabetes may allow for decreasing the incidence of this disease in dogs.
Dr Rebecka Hess
is looking for Samoyeds and Australian Terriers with Diabetes Mellitus. Samoyeds or Australian Terriers without Diabetes Mellitus are also needed as controls. See the trial page for specific infor

Genetics of Cryptorchidism in Siberian Huskies (Study Closed)
January 24, 2008

Genetics of Ectopic Ureters in Newfoundland Dogs (Study Closed)
November 6, 2006

Genetics of Idiopathic Epilepsy in Border Collie Dogs (Study Closed)
November 6, 2006

Identification of genes associated with histiocytic ulcerative colitis (granulomatous colitis of Boxers) (Study Closed)
January 29, 2007

The study hopes to identify genes that may be associated with histiocytic ulcerative colitis in Boxer dogs, in order to enable effective screening and eradication of HUC.
Dr Simpson
is looking for Boxers that have been definitively diagnosed in the past with HUC (GCB) and Boxers that have been free of HUC throughout their lives. DNA samples are required - see Trial page for full details.

Intra-Arterial Chemotherapy for Non-Resectable Canine Urothelial Carcinoma (Study Closed)
September 19, 2008

We hope to determine if superselective intra-arterial administration of chemotherapy and NSAIDs to urothelial tumors results in improved tumor response rates.
Dr Chick Weisse
is looking for dogs with transitional cell carcinoma. See the trial page for specific information on eligibility.

Investigating the Genetic Basis of Hypoadrenocorticism in Standard Poodles (Study Closed)
June 30, 2014

Investigating the Genetic Basis of Hypoadrenocorticism in Standard Poodles
We hope to move towards finding the genetic defect in Standard Poodles with typical hypoadrenocorticism

Investigation of Antigenic Causes of Vaccine-Associated Allergic Reactions in Dogs (Study Closed)
April 25, 2008

Ivermectin Toxicity - (Study Ended)
December 20, 2002

Liposomal Clodronate as a Novel Treatment for Imune-Mediated Hemolytic Anemia in Dogs (Study Closed)
January 30, 2008

Mitochondrial Disorders (Study Closed)
October 18, 2004

Novel Chemotherapy for Canine Multiple Myeloma (Study Closed)
July 24, 2007

Pilot study of re-directed autologous T cell therapy for drug resistant or refractory CD20+ B cell lymphoma (Study Closded)
April 12, 2016

This trial is evaluating whether T lymphocytes, genetically modified to express a chimeric antigen receptor against CD20, can be administered safely to dogs with relapsed B cell lymphoma and whether they can eliminate B cells and prolong overall survival.
Dr Mason is looking for dogs with B-cell lymphoma have relapsed after initial remission.
See the trial page for specific information on eligibility.

Preemptive Gabapentin Administration
February 26, 2007

Protein Losing Enteropathy in Yorkshire Terriers (Study Closed)
January 19, 2009

We are investigating the etiopathogenesis of Protein-Losing Enteropathy (PLE) or Yorkshire Terriers, with particular focus on the development of intestinal crypt lesions, and their role in contributing to enteric protein loss. Since the Yorkshire Terrier is an at-risk breed for development of PLE, we also aim to explore the possibility of a genetic basis to the disease.
Dr Simpson
is looking for Yorkshire Terriers with Protein-losing enteropathy. See the trial page for specif

Renal Failure, Canine - (Study Ended)
September 4, 2002

RMUW-19 Trial (Study Closed)
September 29, 2009

Lymphoma is a readily treatable disease in dogs, with reasonable remission times when using more advanced protocols. SP19 is a modification of the UWM protocol that is less management-intensive.
Dr Rosenthal
is looking for dogs with Lymphoma. See the trial page for specific information on eligibility.

Role of Drug-Specific T Cells in Idiosyncratic Sulfonamide Toxicity in Dogs (Study Closed)
July 21, 2011

We want to determine whether drug-specific T cells can be found in dogs with sulfonamide drug hypersensitivity, and what molecules they target. These results will help us to understand pathogenesis and may help generate prevention strategies.
Dr Trepanier
is looking for dogs with sulfonamide hypersensitivity. See the trial page for specific information on eligibility.

Study of the Genetics of Osteochondrosis in the Great Dane (Study Closed)
June 25, 2008

Testing of Canine Fecal Samples for the Presence of Parvovirus using Real-time PCR, and Genetic Characterization of the Isolates (Study Closed)
July 16, 2008

Transdermal Gel Drug Absorption in Dogs and Cats (Study Closed)
June 9, 2006

West Nile Virus Update - (Study ended)
August 28, 2002

Complete and Published

Cats

Azodyl in Renal Failure Trial (ART): A Pilot Study (Study Closed)
January 30, 2008

Biomarkers for Feline Pancreatic Neoplasia (Study Closed)
March 3, 2010

The purpose of this study is to perform a proteomic comparison of the plasma protein profiles of cats with neoplastic and inflammatory pancreatic diseases to identify differences in protein expression. Such proteins may serve in the future as biomarkers for pancreatic neoplasia.
Dr Meachem
is looking for cats with pancreatic neoplasia or pancreatitis. See the trial page for specific information on eligibility.

Diabetes Treatment Survey (Study Closed)
April 9, 2008

Mirtazapine Use in Cats: Clinical Trial (Study Closed)
October 1, 2010

Phase I Intravenous Docetaxel Treatment of Cats (Study Closed)
September 19, 2008

Radiosurgery Treatment for Cats with Pituitary Tumors: A Pilot Study (Study Closed)
January 30, 2008

The Feline Thyroid Gland: A Model for Endocrine Disruption by PBDEs? (Study Closed)
August 31, 2006

Treatment of Cytauxzoonosis in Cats (Study Closed)
August 28, 2006

Treatment of Feline Oral Squamous Cell Carcinoma (SCC) with 2-Difluoromethylornithine (DFMO) (Study Closed)
December 5, 2006

Dogs

Canine Nasal Carcinoma - (Trial Ended)
November 24, 2003

Canine Thyroid-Aggression Study (Study Closed)
July 13, 2009

Certifect-associated Pemphigus Foliaceus-like Reactions (Study Closed)
April 24, 2012

Chylothorax (Study Closed)
November 19, 2003

Comparative Effect of Pacing Sites in Dogs with Complete Heart Block (Study Closed)
February 4, 2009

Our long term research goal is to optimize pacing techniques for companion animals requiring pacemaker therapy. Such evaluation is justified as complete heart block is a common debilitating condition treated by veterinary cardiologists.
Dr Estrada
is looking for dogs with 3rd degree AV Block. See the trial page for specific information on eligibility.

Cutting Balloon and High Pressure Balloon Valvuloplasty for Dogs with Subaortic Stenosis (Study Closed)
October 10, 2008

Diabetes Treatment Survey (Study Closed)
April 9, 2008

Diagnosis of Immune-Mediated Hemolytic Anemia (IMHA) in Dogs (Study Closed)
August 16, 2012

We hope to improve the diagnosis and monitoring of dogs with IMHA by using several methods. We hope this will lead to a better and standardized diagnostic scheme to diagnose IMHA in dogs
Dr Giger
is looking for dogs with IMHA. The investigators are offering free diagnostic testing on IMHA cases for a limited time See the trial page for specific information on eligibility.

Efficacy of Doxycycline Therapy for Anaplasma Phagocytophilum Infection in Dogs
July 16, 2008

Evaluation of levetiracetam as adjunctive treatment for canine epilepsy (Study Closed)
August 6, 2007

Is Canine Idiopathic Rhinitis Associated with Bartonellosis? (Study Closed)
January 28, 2005

Malignant Hyperthermia in Dogs (Study Closed)
October 15, 2001

Methylprednisolone Sodium Succinate and Polyethylene Glycol in Canine Spinal Cord Injury (Study Closed)
September 18, 2008

This study aims to determine whether adjunctive medical therapy with polyethylene glycol or methylprednisolone sodium succinate improves the outcome of surgically treated dogs with disc herniations more than placebo.
Dr Olby
is looking for dogs with acute thoracolumbar disc herniation that can be taken to one of the participating centers for the study. See the trial page for specific information on eligibility.

MHC Haplotyping in dogs with Acquired Myasthenia Gravis (Study Closed)
September 25, 2008

The purpose of this study is to determine if dogs with acquired myasthenia gravis have similar genes (MHC haplotype). We will use DNA collected from blood cells or from cells from the lining of the mouth to do the genetic analysis. The genetic analysis will be done in the Veterinary School at UC Davis.
Dr Vernau
is looking for dogs with acquired myasthenia gravis. See the trial page for specific information on eligibility.

Minimally-invasive laser ablation for management of intramural ureteral ectopia in dogs (Study Closed)
October 10, 2007

This prospective study will compare a new minimally invasive technique to a historical surgical control for the fixation for intramural ureteral ectopia, to identify differences in post-operative continence rates, level of post-operative urinary infections and parameters of pain in the first week post-intervention. In doing so we hope to determine whether there is a therapeutic advantage to this technique or if there is a significant decrease in post-operative pain.
Dr Berent

Palliative Treatment for Canine Appendicular Osteosarcoma (Study Closed)
December 2, 2004

Pathologic Fracture Risk of Tumor-bearing Canine Antebrachii (Study Closed)
April 15, 2011

This study seeks to correlate calculated CT indices of bone strength with the biomechanically measured actual strength of the bone. It is hoped that correlations found will allow prediction of patients at most risk for pathologic fracture and therefore improve patient selection for treatment options such as palliative radiation therapy when amputation is not elected.
Dr Steffey
is looking for dogs with osteosarcomas of the distal radius requiring limb amputation. See the tria

Prospective randomized clinical trial of doxepin in canine laryngeal paralysis
February 4, 2016

This placebo controlled randomized clinical trial will evaluate the efficacy of doxepin in the treatment of non-critical laryngeal paralysis in Labrador Retrievers.
Dr Rishniw is looking for Labrador Retrievers with laryngeal paralysis.
See the trial page for specific information on eligibility.

Reconstructing the Evolution and Geographic Spread of Early Dogs (Study Closed)
May 12, 2008

Research on Acute Renal Failure in Dogs Associated with Ingestion of Grapes or Raisins (Study Closed)
August 15, 2005

Research on MDR-1 genotype in dogs treated with milbemycin for generalized demodicosis (Study Closed)
May 30, 2006

Trial on Pain Management of Canine Appendicular Osteosarcoma with Aminobisphosphonates (Study Closed)
December 2, 2004

Vector-borne Bacteria in Golden Retrievers with Lymphoma (Study Closed)
May 3, 2005

Other Animals

Evaluation of the proventriculus:keel ratio for determining etiology of proventricular disease in parrots (Study Closed)
December 29, 2007

Rhodococcus equi/Zithromax (Study Ended)
November 5, 2004

Treatment and Outcome of Avian Squamous Cell Carcinoma
September 19, 2012

This survey on avian SCC aims to gather information from practicing veterinarians on what treatments are being used for their patients, how well these are working and what side effects have been observed.
Dr Zehnder
is looking for clinicians to help in a survey about birds with squamous cell carcinoma. See the trial page for specific information on eligibility.

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