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SURVIVAL OF SYMPTOMATIC FELV OR FELV AND FIV POSITIVE CATS TREATED WITH A RECOMBINANT FELINE OMEGA INTERFERON

Mähl P, Maynard L, Karine De Mari K, and Lebreux B

A study was designed to assess the efficacy of a recombinant feline omega interferon (rFeIFNw) in the treatment of symptomatic FeLV or FeLV and FIV positive cats. In a multicentric, controlled, randomised and double blind clinical field trial, 48 FeLV or FeLV and FIV tested cats were included with general clinical signs and/or chronic granulomatous stomatitis. 28 cats were subcutaneously administered 1 million units (MU) interferon per kg b.w. once a day for 5 days and 20 cats received a placebo. Symptomatic treatment including antibiotherapy was allowed in all cats. Cats were clinically observed for 6 months and death date was recorded if applicable. Efficacy was assessed through the survival probabilities which were calculated by the KAPLAN-MEIER method and compared by the LOGRANK test. 13 (46%) cats died during the observation period in rFeIFNw group and 15 (75%) in the placebo group. Comparison of the survival curves showed a statistically significant difference between groups (p = 0.0331). Safety of the product based on clinical examination was excellent. After 5 SC injections of 1 MU/kg rFeIFNw, the survival probability over a 6-month period of FeLV or FeLV and FIV symptomatic cats was 2.2 times higher in the treated cats.


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Oral Presentations
 
Morbidity Factors Of Anxiety Disorders
 
PTT Excision Of Ear Canal Polyps
 
Rabies Antibody Tests: IHA vs Elisa
 
Hip Luxation: Surgical Repair
 
Surgical Repair Of Mitral Regurg.
 
Dental Pulp/Dentin Deposition
 
Ehrlichiosis Study, Azarbaijans
 
B. Thuring. Effects On Trichostrongylus
 
Growth Plate Closure Times, Kangal
 
Revolution, Dog/Cat Flea Control
 
Electrical Stim. For Nerve Injuries
 
BAPN-F For Gastroc. Tendon Healing
 
Patch Test, Dogs; Human Allergy Stats.
 
Abd. Adhesion Prevention, Omenectomy
 
Leptospirosis Study, Tehran
 
Ehrlichiosis, Protein Alterations
 
Xenograft For Femural Fx. Repair
 
Omentum For Tendon Healing
 
Pet Behavior During Bombing
 
Evaluation Of Silk Suture
 
Canine Testis Gene Expression
 
Radiologic Signs, Spirocerca
 
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HbA1c In Diabetic Dogs
 
Bovine Xenograft For Tibial Repair
 
Tibial Segmental Defect, Treatment
 
Bovine Bone Pin For Fracture Repair
 
Rabies Immunity, Tehran, Dogs
 
Oral Antibiotics, Owner Compliance
 
Excision Arthroplasty, Dogs/Cats
 
Ovine Xenograft For Radial Fractures
 
Endochondral Ossification
 
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