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Study Start Date: 01/01/2008
Study End Date: 12/01/2009
Immunophenotyping Feline Myeloma-related Disorders
We have previously shown that cats with myeloma-related disorders (MRD) commonly present with marked extramedullary involvement (67% of cats versus 5% of humans with MRD) (Mellor et al 2006) and that morphological categorization of these tumors is consistent with an extramedullary origin in the majority of feline MRD (Mellor et al 2008). In this next study we will investigate further immunophenotypic markers that may help with sub-typing of these tumors. Improving the understanding of the possible tissue origins of these tumors and sub-typing may lead to better rationales for treatment and prognostication.
Study Design:
Retrospective
Inclusion Criteria:
Cats with a histopathological report of a plasma cell neoplasia / myeloma / plasmacytoma (ante-mortem tissue biopsy or necropsy material).
Exclusion Criteria:
Cats with other conditions or incomplete histopathological diagnosis.
Samples:
Dr Mellor simply requires permission from the primary clinician to request retrieval of the formalin fixed paraffin wax embedded tissue block, from the original laboratory that provided the diagnosis of a plasma cell neoplasm/ myeloma/ plasmacytoma.
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Full Disclosure information:
- The study is funded by a grant from University of Edinburgh and Dr Mellor.
- The investigators do not have any conflict of interest.
- The study will be published if results are negative.
- The study will be reported on VIN.
- The authors will acknowledge VIN if the study is published.