Evaluation of a new diet for managing Dalmatians that have had urate bladder stones (Study Closed)
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Study Start Date: 01/01/2007
Study End Date: 06/30/2008
Evaluation of a new diet for managing Dalmatians that have had urate bladder stones
The objectives of this study include determining the influence of a protein hydrolysate diet on laboratory parameters including urinary saturation with urate in Dalmatians, and comparing these results with an ultra-low protein diet used routinely for management of urate urinary stones in Dalmatians.
We are looking for Dalmatians that have had urate bladder stones. The study involves collecting 24-hour urine samples from Dalmatians while they are consuming 2 different diets. Dogs will not receive allopurinol, a drug used to manage urate stones, during the study. All costs are covered by the project.
Study Design:
Prospective, Cross-over, Randomized, Double-blinded.
Sample Size:
12 dogs
Inclusion criteria:
- Male Dalmatian with a history of, but not active, urate urinary bladder stones that are otherwise healthy.
- Owners willing to visit The University of Tennessee and allow their dog to be hospitalized for 24 hours three times over 12 weeks.
Exclusion Criteria:
- Dogs with other serious illness (such as heart disease or kidney or liver failure) and those requiring dietary modification will be excluded.
- Dogs receiving medication for other diseases (e.g. antibiotics for skin disease or levothyroxine supplementation for hypothyroidism) may be included if the treatment is approved by the principal investigator.
- Inability to feed the dog either diet or inability to return to The University of Tennessee.
Study Controls:
The study is a cross-over study where dogs serve as their own controls.
Study Endpoints:
Diets will be fed for 6 weeks at which time 24-hour urine samples and blood samples will be collected for estimation of urinary saturation.
Samples:
No samples will be submitted.
Costs/Reimbursements:
Cost of evaluations are covered by the project. Diets are provided at no cost to owner.
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Full Disclosure information:
- The study is funded by a grant from Nestle Purina.
- The investigator has presented Pet-food-company-sponsored lecture on urolithiasis.
- The study will be published if results are negative.
- The study will be reported on VIN.
- The authors will acknowledge VIN if the study is published.
- Owners will need to sign an informed consent form.