ABSTRACT OF THE WEEK

Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Volume 48 | Issue 3 (June 2020)

Nasal transmissible venereal tumours in 12 dogs - a retrospective study.

Nasales Sticker-Sarkom bei 12 Hunden – eine retrospektive Studie.

Tierarztl Prax Ausg K Kleintiere Heimtiere. June 2020;48(3):164-170.

Nataliia Ignatenko¹, Irina Abramenko², Sara Soto³, Ralf Müeller⁴, Teresa M S A Boehm⁵, Karin Troedson⁶, Csilla Fejos⁷, Johannes Hirschberger⁸

¹ Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilian University.; ² Clinical Immunology Department, Research Center for Radiation Medicine.; ³ Institute of Animal Pathology, Vetsuisse Faculty, University of Berne.; ⁴ Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilian University.; ⁵ Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilian University.; ⁶ Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilian University.; ⁷ Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilian University.; ⁸ Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilian University.

© Georg Thieme Verlag KG Stuttgart · New York.

Abstract

OBJECTIVE:The aim of this study was a retrospective analysis of clinical manifestation and treatment outcome of the nasal form of transmissible venereal tumours (TVT).

MATERIAL AND METHODS:Twelve dogs suffering from nasal TVT were included in this study. Patients with primary genital lesions were excluded from the study. Signalment, physical examination and laboratory findings, results of further diagnostics, and treatment results were recorded in all patients.

RESULTS:The study population comprised 9 male and 4 female dogs with an (estimated) age ranging from 3 to 7 years. With one exception all dogs originated from Ukraine. Symptoms of nasal TVT included sneezing, nasal bleeding (all cases), skull infiltration (9 cases), oronasal fistulas (9 cases) and cutaneous fistulas (5 cases). Animals received vincristine sulfate at 0.7 mg/m² i. v. weekly. The treatment course consisted of 4-9 cycles (median 5 cycles). Complete remission was achieved in all cases. All dogs were disease-free during the follow-up period (median 23.5 months, range 12-56 months). All patients tolerated the treatment very well.

CLINICAL SIGNIFICANCE:In conclusion, our data suggest that nasal TVT can have a good response to vincristine treatment. TVT should be considered as a differential diagnosis in sneezing dogs with nasal discharge or bleeding especially in young dogs and in dogs with suspected nasal tumours, even in countries without a stray animal population.

PubMed Other Abstract

ZIEL: Das Ziel dieser Studie war, die klinische Manifestation der nasalen Form des transmissiblen venerischen Tumors (TVT, Sticker-Sarkom) und die Wirksamkeit einer Therapie mit Vincristin retrospektiv zu analysieren.

MATERIAL UND METHODEN:In die Studie wurden 12 Hunde mit einem nasalen TVT einbezogen. Patienten mit primären Genitalläsionen blieben von der Studie ausgeschlossen. Die Auswertung erstreckte sich auf Signalement der Hunde, klinische und labordiagnostische Befunde, Befunde weiterführender Diagnostik sowie Ansprechen auf die Behandlung.

ERGEBNISSE:Bei den Patienten handelte es sich um 9 Rüden und 4 Hündinnen im (geschätzten) Alter von 3–7 Jahren, die mit einer Ausnahme aus der Ukraine stammten. Die Symptome waren Niesen, Nasenbluten (n = 12), Infiltration des Schädels (n = 9), oronasale Fisteln (n = 9) und Hautfisteln (n = 5). Die Tiere erhielten Vincristinsulfat 0,7 mg/m² i. v. wöchentlich in 4–9 Sitzungen (Median 5 Sitzungen). In allen Fällen wurde eine vollständige Remission erreicht und keiner der Hunde zeigte in der Nachbeobachtungszeit (Median 23,5 Monate, Bereich 12–56 Monate) Symptome des TVT. Alle Patienten vertrugen die Behandlung sehr gut.

SCHLUSSFOLGERUNG:Den Ergebnissen zufolge spricht der TVT gut auf eine Behandlung mit Vincristin an. Diese Neoplasie sollte bei niesenden Hunden mit Nasenausfluss, nasalen Blutungen und Gesichtsdeformationen differenzialdiagnostisch Berücksichtigung finden. Dies gilt insbesondere für junge Tiere mit Verdacht auf Nasentumoren, auch wenn diese nicht aus Ländern mit streunenden Hunden stammen.

Article Tools:

Medline

Email to me

Archives Highlights:

Use of Dog Serologic Data for Improved Understanding of Coccidioidomycosis: A One Health Approach.
The overall seropositivity rate among tested dogs was 37.6%. Average test positivity rates in states with =0.5 tests per annum per 10,000 households were 35.4% (Texas) to 74.1% (Montana). For these states, average annual incidence per 10,000 households was as follows: Arizona (86.8), New Mexico (0.89), Nevada (0.78), California (0.75), Montana (0.63), Colorado (0.41), Oregon (0.41), Texas (0.38), Idaho (0.37), Wyoming (0.34), Utah (0.32), and Washington (0.26). Human incidence in California and Arizona between 2012 and 2022 was significantly correlated with dog incidence.

Guide for nonswine practitioners to enhance swine disease diagnoses.
This review aims to help clinicians across the country that may not have an in-depth experience in swine medicine become more familiar with both common and novel pathogens, formulate a differential diagnosis based on the age of the animals and affected system (eg, respiratory, systemic, nervous, and enteric), select proper samples and laboratory testing, and interpret laboratory data to achieve a disease diagnosis in porcine patients.

Resolution of egg binding is possible in most client-owned parrots when multiple treatment strategies are considered.
Of the 150 events that had complete follow-up, 109 (72.7%) resulted in a successful outcome. A successful outcome was observed in 44 of 133 events (33.1%) that were initially managed medically without resorting to additional treatment strategies, in 31 events (86.1%) managed with mechanical assistance, in 20 events (60.6%) managed surgically, and in 12 events (85.7%) managed with ovocentesis.

Challenges and Outlook of Veterinary Education in Iran: A Survey of Veterinary Students at Urmia University During the COVID-19 Pandemic.
Regarding future employment, 45.8% of participants wanted to start their own business or practice, whereas 54.2% preferred employment opportunities. A significant 81.6% of participants said they would consider emigrating to pursue better career prospects.

How to plan and provide general anesthesia for a troop of 98 hamadryas baboons (Papio hamadryas) for contraceptive and preventative health interventions.
A group of 12 veterinarians, 2 zookeepers, and 6 volunteers anesthetized all animals within 2 days. The baboons were orally premedicated with midazolam (0.1 to 0.5 mg/kg) and anesthetized with medetomidine (40 to 60 µg/kg, IM) and ketamine (2 to 4 mg/kg, IM); isoflurane at rates of 1.5% to 2% was used for maintaining anesthesia if necessary. For population management, the animals received a contraceptive implant (adult females), orchiectomy (young males), or vasectomy (breeding males).