Minimum effective naltrexone dose to antagonise etorphine immobilisation and prevent the complications of renarcotisation in domestic goats.

Vet Rec. November 2017;181(18):481.

Jacques Henry O'Dell¹, Michael David Kock², Peter Neil Thompson³, Leith Carl Rodney Meyer⁴

¹ Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.; ² Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.; ³ Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.; ⁴ Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.

Abstract

Naltrexone is used to antagonise etorphine immobilisation, but a safe and effective dose for this purpose has not been objectively determined. Eight domestic goats were immobilised with etorphine (0.07 mg/kg) eight times at ≥13 day intervals. Naltrexone at doses of 0.5, 1, 2, 5, 10, 20 and 40 mg/mg etorphine were administered intravenously 17 minutes after etorphine injection. Effectiveness of antagonism was recorded based on recovery and renarcotisation scores and clinical observations. All doses produced rapid recovery to the point of standing (median 59 seconds, range 33-157 seconds), with no significant differences in recovery times (P=0.44). The lower naltrexone doses resulted in renarcotisation in some goats: 4/8 in the 10-mg dose trial, 7/8 in the 5-mg dose trial, and 8/8 in the 2-mg, 1-mg and 0.5-mg dose trials. Lower doses resulted in more severe signs of renarcotisation. Complications of renarcotisation included increased body temperature; this occurred just before signs of renarcotisation and was greater in animals with high renarcotisation scores (P<0.01). The lowest, safest effective naltrexone dose that we used to antagonise etorphine immobilisation was 20 mg/mg etorphine, which produced rapid recovery to standing with no renarcotisation.

Keywords

Antagonist; etorphine; goats; hyperthermia; immobilisation; naltrexone; renarcotisation; reversal; wildlife;

Article Tools:

Medline

Email to me

Archives Highlights:

Prevalence of Encephalitozoon hellem among companion and exhibition birds in Japan.
Although microsporidia can rarely cause severe systemic infections, including hepatitis, nephritis, and enteritis in young birds, most infected birds are subclinical and thought to recover spontaneously after a period of temporary spore shedding if they do not have immunosuppression. Microsporidia can cause self-limiting infection in immunocompetent humans and life-threatening chronic diarrhea in immunocompromised individuals.

Endoparasites of rabbits and hares.
Accurate gross and microscopic identification of endoparasites in rabbits and hares is an important element of the diagnostic work of veterinary anatomic pathologists. Given the zoonotic nature of rabbit and hare endoparasites, such as C. hepatica, E. cuniculi, and others, veterinary pathologists are ideally poised to make valuable contributions to the understanding of the disease ecology of these pathogens in the context of a One Health research program.

Choose Your Own Adventure: Using Twine for Gamified Interactive Learning in Veterinary Anaesthesia.
Five interactive clinical cases were developed using Twine, simulating realistic anaesthesia scenarios with decision points and gamified elements, such as scoring systems and resource management. Feedback was highly positive; 90.8% found it effective for training, and 97.0% agreed it improved knowledge. User-friendliness was rated as "easy" or "very easy" by 94.6%. Regarding overall satisfaction, 96.7% of students described the workshop as "good" or "excellent".

Limb amputation for feline appendicular bone tumors results in excellent recovery outcomes and high owner satisfaction with a low incidence of complications.
Time to return to walking without support was < 3 days in 69.7% of cats and 3 to 7 days in 16.7%. Activity level changes were reported as no change in 75.8% of cats. There were no behavioral changes in 92.3% of cats. Quality of life following amputation was recorded as excellent in 82.4% of cats. Owner satisfaction was reported as very satisfied, moderately satisfied, or satisfied in 98.5% of cats.

Feline acute patient physiologic and laboratory evaluation scores and other prognostic factors in cats with first-time diabetic ketoacidosis.
Median BG was significantly higher in non-survivors (431 mg/dL) compared with survivors (343 mg/dL) and BG predicted mortality. For every 1 mg/dL increase in BG, the odds of death increased by 1.004.