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Investigating the Genetic Basis of Hypoadrenocorticism in Standard Poodles (Study Closed)
February 1, 2014 (published) | June 30, 2014 (revised)
Katharine Lunn

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Study Start Date: 02/01/2014
Study End Date: 06/30/2015

Investigating the Genetic Basis of Hypoadrenocorticism in Standard Poodles.
Researchers at North Carolina State University are investigating the genetic basis of several immune- mediated diseases. Poodles with hypoadrenocorticism is one population that we are targeting, because the phenotype (clinical manifestations) of the disease is easy to determine, from serum electrolyte values and results of an ACTH stimulation test. We would like to compare blood samples from Standard Poodles with confirmed typical hypoadrenocorticism (Addison's disease) with samples from Standard Poodles over 10 years of age that have normal ACTH stimulation test results.

Study Design:
Prospective case-controlled

Sample Size:

Inclusion Criteria:

  • Purebred Standard Poodle with typical hypoadrenocorticism.
  • Must have laboratory tests that demonstrate hyponatremia and/or hyperkalemia.
  • An ACTH stimulation test that confirms hypoadrenocorticism.
  • Diagnosis could have been made at any time in the life of the dog

Exclusion Criteria:

  • Breeds other than standard poodles
  • Unconfirmed diagnosis (either lack of electrolyte changes or normal ACTH stimulation test)

Study Controls:
Standard Poodles that have had a normal ACTH stimulation test performed and documented at > 10 years old.

EDTA blood samples are required. Investigators will provide tubes and all shipping materials. Refrigerate until shipped.

Investigator will provide EDTA tubes. We will provide all shipping materials and pre-paid shipping labels.

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For more information see:
Website about the Addison's study

Full Disclosure information:

  • The study is funded by a grant from NCSU.
  • The investigator does not have a conflict of interest.
  • The study will be published if results are negative.
  • The study will be reported on VIN.
  • The authors will acknowledge VIN if the study is published.

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