Study Start Date: 01/01/2007
Study End Date: 8/31/2013

Identification of genes associated with histiocytic ulcerative colitis (granulomatous colitis of Boxers)

Histiocytic ulcerative colitis (HUC; also known as granulomatous colitis of Boxers) is a chronic, severe gastrointestinal disease of typically seen in young Boxer dogs. Affected dogs usually present with signs of large bowel disease, initially frequent bloody mucoid stools, often progressing to chronic debilitation, weight loss, anemia, and hypoalbuminemia. Clinical signs are usually unresponsive to immunosuppressive therapy, and recent work in our laboratory strongly suggests a breed- specific defect in host defense is linked to invasion and persistence of E. coli within the colonic mucosa.

To enable effective screening and eradication of HUC we are trying to identify the genetic basis of HUC in Boxer dogs. We are currently collecting DNA and serum samples from affected Boxer dogs. See inclusion criteria below.

See HUC Flyer (PDF).

Study Design:
Prospective, observational, genomic study.

Sample Size:
30 affected Boxers
30 control Boxers

Inclusion criteria:

1. Boxer dogs of any age or sex, in whom a definitive diagnosis of histiocytic ulcerative colitis (HUC) has been reached (with available histology report).
2. Dogs do not have to be exhibiting clinical signs, but can be in remission. If they have had a previous confirmed diagnosis, they are eligible to participate in this study.

Exclusion Criteria:

1. Boxers with a presumptive diagnosis of HUC without histopathological confirmation of the disease.

Study Controls:
Boxers not affected by HUC. HUC usually affects Boxers <4 years of age. Older Boxers that have never had clinical signs of HUC are potential control candidates. We are especially interested in Boxers that have been diagnosed with Arrhythmogenic Right Ventricular Cardiomyopathy as a control group.

Samples:
EDTA 5mls and Serum 1-2 mls (ideally separated). Endoscopic biopsies from potentially affected Boxer dogs, please call the lab for sample collection tubes.

Costs/Reimbursements:
No.

Full Disclosure information:

• The study is funded by an institutional (intramural) grant.
• The investigator has presented Pet-food-company-sponsored lectured on Boxer colitis.
• The investigator is on the advisory board of Royal Canin and Purina.
• The investigator has received support from Pharmaceutical and Pet-food companies in the past.
• The study will not be published if results are negative.
• The study will be reported on VIN.
• The authors will acknowledge VIN if the study is published.
• Owners will not need to sign an informed consent form.