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Category: Dogs

Drug Toxicity (Study Closed)
August 18, 2003 (published)
Dr. Katrina L. Mealey
You do not have permission to view this document: [5990356]!

Request for Samples—Herding breeds (collies, shelties, etc) experiencing adverse drug reactions

The Veterinary Clinical Pharmacology Laboratory at Washington State University is seeking samples for a research project funded by the Collie Club of America Foundation. The objective of the project is to determine if dogs with the MDR1 mutation associated with ivermectin sensitivity are also susceptible to toxicities from other drugs.

We are requesting cheek swab samples from dogs that have experienced unexpected toxicity from “normal” doses of drugs, particularly drugs that are P-glycoprotein substrates such as digoxin, cyclosporine A, doxorubicin, vincristine, vinblastine, some steroids, acepromazine, ondansetron, and potentially other antiparasitic agents (milbemycin, selamectin, moxidectin). We will also accept samples from dogs with suspected toxicity (particularly neurotoxicity) from other drugs.

You do not have permission to view this document: [6079851]!

Reviewed 12/5/05

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