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Category: Cats

Clinical Research on Serum Markers for Feline Enteropathies (Study Closed)
June 18, 2010 (published)
Kenny Simpson
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Study Start Date: 07/01/2010
Study End Date: 07/01/2011

We recently discovered that interleukin-6 (IL-6) is markedly upregulated in the intestinal mucosa of cats with IBD and alimentary lymphoma. We would now like to evaluate the serum of cats with enteric disease for non-invasive markers of enteric disease, including IL-6. We are seeking serum samples from cats with chronic GI signs that have been definitively diagnosed by histologic biopsy with either IBD OR alimentary lymphoma.

Study Design:
Prospective case-control study

Sample Size:
50 IBD cats, 50 lymphoma

Inclusion Criteria:

  • Adult cats of any breed with a recent diagnosis on histology of IBD or intestinal lymphoma.
  • Not receiving any chemotherapy, anti-inflammatory or other immunosuppressive medication.
  • No known concurrent disease, e.g., pancreatic, hepatic, or renal disease, hyperthyroidism.
  • Known FeLV/FIV status.

Exclusion Criteria:

  • Presumptive diagnosis of IBD or lymphoma without histologic confirmation.
  • Cats previously diagnosed and now in remission

Study Controls:
Healthy cats that have already undergone intestinal biopsy for an earlier study will be used as historical controls.

Study Endpoints:


SEPARATED SERUM 1-2 mls. Stored refrigerated or frozen and shipped on an ice pack.


You do not have permission to view this document: [5943471]!

Full Disclosure information:

  • The study is funded by an intramural institutional grant.
  • The investigator does not have a conflict of interest.
  • The study will be published if results are negative.
  • The study will be reported on VIN.
  • The authors will acknowledge VIN if the study is published.

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