Published results can be found here and here.

Study Start Date: 07/01/2006
Study End Date: 07/01/2008

Treatment of Cytauxzoonosis in Cats

Cytauxzoonosis is an often fatal disease of cats. Historical survival rates are <5%. This study aims to compare the efficacy of two anti-protozoal treatment regimens for cytauxzoonosis. Preliminary data suggests that these treatments may be associated with survival rates from 50-65% compared to previously described survival rates. We are looking to enroll hospitals that see at least 3 confirmed cases of C. felis per year.

Dr. Cohn recently hosted a VIN Rounds on this disease.

Inclusion criteria:
1) Clinical presentation compatible with cytauxzoonosis
2) Cytologic demonstration of suspected C. felis piroplasms or schizonts or molecular evidence of cytauxzoonosis confirmed by polymerase chain reaction (PCR).
3) Fully-informed owner consent.
4) Hospitals that diagnose at least 3 cases/year of C. felis.

Exclusion Criteria:
Cats in a moribund state or suffering hypothermia.

Study Sample Size:
60 cats

Study Controls:
Each treatment group will serve as the control for the other. No cats will be enrolled in a standard-of-care arm. Historical controls will be used.

Study Endpoints:
Survival / all-cause mortality, death due to C .felis.

Samples:
EDTA anti-coagulated whole blood samples will need to be obtained at specified periods. Sampling kits will be mailed out to the veterinarian, along with an instruction sheet and shipping information.

Costs/Reimbursements:
The investigators will reimburse clients $100.00 for each case, free PCR testing and free treatment study drugs. Clinicians will be provided with free blood sample submission.

Full Disclosure information:

• The study is funded by institutional (university intramural) funds.
• The investigators have declared that they have no conflict of interest.
• The study will be published if results are negative
• The study will be reported on VIN if there is no compromise to publication potential.
• The authors will acknowledge VIN if the study is published if substantial case recruitment is credited to VIN participation.