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Category: Dogs

Certifect-associated Pemphigus Foliaceus-like Reactions (Study Closed)
April 24, 2012 (published)
Dr. Thierry Olivry

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Published results can be found here.

Study Start Date: 04/01/2012
Study End Date: 03/31/2013

Certifect-associated Pemphigus Foliaceus-like Reactions

Our group recently reported that the topical application of an amitraz-metaflumizone flea and tick control product (Promeris Duo, Pfizer) triggered the rare development of autoimmune pemphigus foliaceus (PF) in dogs. Lesions first appeared at the site of application before developing at typical PF sites. With the recent anecdotes of similar reactions occurring at the site of another concentrated amitraz-containing product (Certifect, Merial), we are interested to study the immune reaction occurring during these reactions.

Study Design:
Prospective case series

Inclusion Criteria:

  • Dog has received Certifect on the dorsum
  • Crusted skin lesions developed at the site of Certifect application
  • Skin biopsies were taken and confirmed that lesions resembled those of pemphigus foliaceus

Exclusion Criteria:

  • Application of other topical at the site of crusted lesion development


  1. Collect at least 5 ml of blood, spin serum and freeze until shipment
  2. Contact author for study questionnaire (
  3. Complete study questionnaire and attach pathology report

Clients and veterinarians will not be reimbursed for sample submission.

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Full Disclosure information:

  • The study is NOT funded.
  • The investigator does not have a conflict of interest.
  • The study will be published if results are negative.
  • The authors will acknowledge VIN if the study is published with substantial VIN contribution to case recruitment.

Date published: 04/24/2012

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