Genetic

  • Granulomatous Disease  
    January 7, 2015
    Search For A Dog With X-Linked Chronic Granulomatous Disease
    Drs. Harry Malech and Sebastian Brenner
    Examples of canine patients that may be of value to them are young Weimaraners with recurrent infection secondary to suspected neutrophil dysfunction, or young dogs from other breeds with a history of chronic recurring infections, particularly with organisms such as Aspergillus, Staphylococcus, Serratia or Burkholderia cepacia.
  • Hereditary Evaluation of Legg-Calve-Perthes Disease in Toy and Miniature Breeds  
    November 3, 2008
    Legg-Calve-Perthes Disease (LCPD) is a developmental disorder affecting the hip joint of small-breed puppies. Our study aims to identify (1) the mode of inheritance of LCPD in several small breeds and (2) candidate genes that may either cause the disease or be involved in the disease process through whole-genome association mapping.
    Dr Starr
    is looking for dogs with Legg-Calve-Perthes disease. See the trial page for specific information on eligibility.
  • Hereditary evaluation of spina bifida and cleft palate in brachycephalic dogs  
    January 20, 2009
    We hope to identify candidate genes associated with canine structural birth defects, specifically spina bifida and cleft lip/palate in the bulldog and other brachycephalic breeds. This would allow us to develop a genetic test that could identify affected dogs and carrier dogs.
    Dr Starr
    is looking for Bulldogs or brachycephalic dogs with spina bifida or labio-palatine closure defects. See the trial page for specific information on eligibility.
  • Hypertrophic Osteodystrophy (HOD): Identifying the Genes Responsible  
    December 31, 2013
    This study aims to identify the molecular cause for hypertrophic osteodystrophy. HOD is a familial disorder with an unknown etiology.
    Dr Safra
    is looking for dogs with hypertrophic osteodystrophy. See the trial page for specific information on eligibility.
  • Identification of Genetic Risk in Collies and Shetland Sheepdogs with Epilepsy  
    July 20, 2022
    Objectives: 1. Conduct a genome-wide association study (GWAS) to identify genomic regions associated with epilepsy in collies and shetland sheepdogs 2. Generate whole genome resequencing data to identify putative causal variants in associated regions.
    Dr Clark is looking for Collies and Shetland Sheep dogs with epilepsy. See the trial page for specific information on eligibility.
  • Molecular mapping and characterization of the genetic modifier associated with Collie Eye Anomaly (CEA) and Colobomas  
    July 19, 2022
    To determine genetic modifiers contributing to Coloboma formation in collies
    Dr Aguirre is looking for Collies with colobomas. See the trial page for specific information on eligibility.
  • Risk Factors for Nutritionally-mediated DCM in Healthy Dogs of 2 Size Groups: The Role of Diet Category, Taurine, Cardiac Biomarkers, and Metabolomics  
    February 19, 2024
    We hope to identify differences in cardiac parameters related to diet and/or breed size, and to investigate underlying factors that may be related to those differences.
    Drs Larsen and Stern are looking for dogs fed “grain free” diets.


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