Disease

Degenerative
Genetic Mapping of Legg Calve Perthes Disease
August 4, 2015

Legg Calve Perthes Disease (avascular necrosis of the femoral head) affects dogs. A genetic basis is suspected.
Dr Todhunter is looking for dogs with Legg Calve Perthes Disease.
See the trial page for specific information on eligibility.
Hereditary Evaluation of Legg-Calve-Perthes Disease in Toy and Miniature Breeds
November 3, 2008

Legg-Calve-Perthes Disease (LCPD) is a developmental disorder affecting the hip joint of small-breed puppies. Our study aims to identify (1) the mode of inheritance of LCPD in several small breeds and (2) candidate genes that may either cause the disease or be involved in the disease process through whole-genome association mapping.
Dr Starr
is looking for dogs with Legg-Calve-Perthes disease. See the trial page for specific information on eligibility.
Incidence, Prevalence, and Genetics of Canine Diabetes
May 15, 2017

The survey hopes to use this data to investigate the prevalence, incidence, and potentially mode of inheritance of diabetes mellitus in dogs at increased risk for the disease, as well as that of the general population and those at decreased risk.
Dr Cai is looking for dogs with and without diabetes mellitus.
See the trial page for specific information on eligibility.
Prospective randomized clinical trial of doxepin in canine laryngeal paralysis
February 4, 2016

This placebo controlled randomized clinical trial will evaluate the efficacy of doxepin in the treatment of non-critical laryngeal paralysis in Labrador Retrievers.
Dr Rishniw is looking for Labrador Retrievers with laryngeal paralysis.
See the trial page for specific information on eligibility.
Developmental
Hereditary evaluation of spina bifida and cleft palate in brachycephalic dogs
January 20, 2009

We hope to identify candidate genes associated with canine structural birth defects, specifically spina bifida and cleft lip/palate in the bulldog and other brachycephalic breeds. This would allow us to develop a genetic test that could identify affected dogs and carrier dogs.
Dr Starr
is looking for Bulldogs or brachycephalic dogs with spina bifida or labio-palatine closure defects. See the trial page for specific information on eligibility.
Genetic
Granulomatous Disease
January 7, 2015

Search For A Dog With X-Linked Chronic Granulomatous Disease
Drs. Harry Malech and Sebastian Brenner
Examples of canine patients that may be of value to them are young Weimaraners with recurrent infection secondary to suspected neutrophil dysfunction, or young dogs from other breeds with a history of chronic recurring infections, particularly with organisms such as Aspergillus, Staphylococcus, Serratia or Burkholderia cepacia.
Hereditary Evaluation of Legg-Calve-Perthes Disease in Toy and Miniature Breeds
November 3, 2008

Legg-Calve-Perthes Disease (LCPD) is a developmental disorder affecting the hip joint of small-breed puppies. Our study aims to identify (1) the mode of inheritance of LCPD in several small breeds and (2) candidate genes that may either cause the disease or be involved in the disease process through whole-genome association mapping.
Dr Starr
is looking for dogs with Legg-Calve-Perthes disease. See the trial page for specific information on eligibility.
Hereditary evaluation of spina bifida and cleft palate in brachycephalic dogs
January 20, 2009

We hope to identify candidate genes associated with canine structural birth defects, specifically spina bifida and cleft lip/palate in the bulldog and other brachycephalic breeds. This would allow us to develop a genetic test that could identify affected dogs and carrier dogs.
Dr Starr
is looking for Bulldogs or brachycephalic dogs with spina bifida or labio-palatine closure defects. See the trial page for specific information on eligibility.
Hypertrophic Osteodystrophy (HOD): Identifying the Genes Responsible
December 31, 2013

This study aims to identify the molecular cause for hypertrophic osteodystrophy. HOD is a familial disorder with an unknown etiology.
Dr Safra
is looking for dogs with hypertrophic osteodystrophy. See the trial page for specific information on eligibility.
Identification of Genetic Risk in Collies and Shetland Sheepdogs with Epilepsy
July 20, 2022

Objectives: 1. Conduct a genome-wide association study (GWAS) to identify genomic regions associated with epilepsy in collies and shetland sheepdogs 2. Generate whole genome resequencing data to identify putative causal variants in associated regions.
Dr Clark is looking for Collies and Shetland Sheep dogs with epilepsy. See the trial page for specific information on eligibility.
Molecular mapping and characterization of the genetic modifier associated with Collie Eye Anomaly (CEA) and Colobomas
July 19, 2022

To determine genetic modifiers contributing to Coloboma formation in collies
Dr Aguirre is looking for Collies with colobomas. See the trial page for specific information on eligibility.
Risk Factors for Nutritionally-mediated DCM in Healthy Dogs of 2 Size Groups: The Role of Diet Category, Taurine, Cardiac Biomarkers, and Metabolomics
February 19, 2024

We hope to identify differences in cardiac parameters related to diet and/or breed size, and to investigate underlying factors that may be related to those differences.
Drs Larsen and Stern are looking for dogs fed “grain free” diets.
Inflammatory/Infectious
Granulomatous Disease
January 7, 2015

Search For A Dog With X-Linked Chronic Granulomatous Disease
Drs. Harry Malech and Sebastian Brenner
Examples of canine patients that may be of value to them are young Weimaraners with recurrent infection secondary to suspected neutrophil dysfunction, or young dogs from other breeds with a history of chronic recurring infections, particularly with organisms such as Aspergillus, Staphylococcus, Serratia or Burkholderia cepacia.
Transcriptome Profiling of Canine Familial Dermatomyositis (DMS) Skin Lesions and Treatment in Collies and Shetland sheepdogs
July 20, 2022

To evaluate the molecular signature of canine familial DMS using RNA sequencing in Collies and Shelties.
Dr Banovic is looking for Collies and Shelties with cutaneous dermatomyositis. See the trial page for specific information on eligibility.
Use of Canine Struvite Dissolution Diet in the Management of Infection Induced Struvite Stones in Dogs
August 30, 2017

We hope to provide another effective dietary option to struvite dissolution in dogs. By feeding the test diet (brand blinded to client) and antibiotics we expect that dissolution of canine struvite bladder stones will occur within a 12-week period.
Dr Westropp is looking for dogs with struvite uroliths.
See the trial page for specific information on eligibility.
Neoplastic
Canine Mammary Tumors: Time to Second Tumor Investigation
June 7, 2006

This study aims to delineate the median time from first mammary gland tumor in a dog to the second mammary gland tumor as a baseline for future mammary tumor chemoprevention trials.
Dr Phil Bergman
is looking for dogs that have had mammary tumor recurrence. All information is submitted via the survey form on the trial page.
Contrast Enhanced Imaged Guided Surgery for Cancer
October 28, 2011

We hope to determine if a novel imaging system accurately delineates tumors and their margins during surgery.
Dr Holt
is looking for dogs with primary lung tumors, mammary tumors or soft-tissue sarcomas amenable to surgical resection. See the trial page for specific information on eligibility.
Neoplastic
Measurement of IL-31 Levels in Dogs with Cutaneous Epitheliotropic T Cell Lymphoma: Its Association with Pruritus and the use of Lokivetmab (Cytopoint) as an Antipruritic Treatment
September 10, 2021

Humans as well as dogs with cutaneous epitheliotropic T cell lymphoma (CETL) often suffer from intense itchiness which can cause significant discomfort and can affect quality of life. Can this itchiness be controlled with Cytopoint?
Dr Souza is looking for dogs with epitheliotropic T-cell Lymphoma. See the trial page for specific information on eligibility.
Nutrtition
Use of Canine Struvite Dissolution Diet in the Management of Infection Induced Struvite Stones in Dogs
August 30, 2017

We hope to provide another effective dietary option to struvite dissolution in dogs. By feeding the test diet (brand blinded to client) and antibiotics we expect that dissolution of canine struvite bladder stones will occur within a 12-week period.
Dr Westropp is looking for dogs with struvite uroliths.
See the trial page for specific information on eligibility.
Toxic
Other
Identification of Genetic Risk in Shetland Sheepdogs with Gallbladder Mucocele Formation
December 4, 2023

The long term goal of this research is to determine which gene(s) are responsible for predisposition of Shetland sheepdogs to mucocele formation. This will enable a better understanding of pathogenesis of mucocele formation in this breed.
Dr. Gookin is looking for Shetland Sheepdogs with gallbladder mucocele. See the trial page for specific information on eligibility.
Prospective evaluation of a minimally invasive treatment option for extrahepatic biliary duct obstructions (EHBDO) in dogs and cats
January 14, 2015

This FULLY FUNDED study evaluates the treatment for extra hepatic biliary duct obstruction (EHBDO) in dogs and cats using endoscopy and retrograde stenting to improve the morbidity and mortality.
Dr Berent is looking for dogs and cats with biliary obstructions. See the trial page for specific information on eligibility.

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