Disease

  • Degenerative  

  • Genetic Mapping of Legg Calve Perthes Disease  
    August 4, 2015
    Legg Calve Perthes Disease (avascular necrosis of the femoral head) affects dogs. A genetic basis is suspected.
    Dr Todhunter is looking for dogs with Legg Calve Perthes Disease.
    See the trial page for specific information on eligibility.
  • Hereditary Evaluation of Legg-Calve-Perthes Disease in Toy and Miniature Breeds  
    November 3, 2008
    Legg-Calve-Perthes Disease (LCPD) is a developmental disorder affecting the hip joint of small-breed puppies. Our study aims to identify (1) the mode of inheritance of LCPD in several small breeds and (2) candidate genes that may either cause the disease or be involved in the disease process through whole-genome association mapping.
    Dr Starr
    is looking for dogs with Legg-Calve-Perthes disease. See the trial page for specific information on eligibility.
  • Incidence, Prevalence, and Genetics of Canine Diabetes  
    May 15, 2017
    The survey hopes to use this data to investigate the prevalence, incidence, and potentially mode of inheritance of diabetes mellitus in dogs at increased risk for the disease, as well as that of the general population and those at decreased risk.
    Dr Cai is looking for dogs with and without diabetes mellitus.
    See the trial page for specific information on eligibility.
  • Prospective randomized clinical trial of doxepin in canine laryngeal paralysis  
    February 4, 2016
    This placebo controlled randomized clinical trial will evaluate the efficacy of doxepin in the treatment of non-critical laryngeal paralysis in Labrador Retrievers.
    Dr Rishniw is looking for Labrador Retrievers with laryngeal paralysis.
    See the trial page for specific information on eligibility.

  • Developmental  

  • Hereditary evaluation of spina bifida and cleft palate in brachycephalic dogs  
    January 20, 2009
    We hope to identify candidate genes associated with canine structural birth defects, specifically spina bifida and cleft lip/palate in the bulldog and other brachycephalic breeds. This would allow us to develop a genetic test that could identify affected dogs and carrier dogs.
    Dr Starr
    is looking for Bulldogs or brachycephalic dogs with spina bifida or labio-palatine closure defects. See the trial page for specific information on eligibility.

  • Genetic  

  • Granulomatous Disease  
    January 7, 2015
    Search For A Dog With X-Linked Chronic Granulomatous Disease
    Drs. Harry Malech and Sebastian Brenner
    Examples of canine patients that may be of value to them are young Weimaraners with recurrent infection secondary to suspected neutrophil dysfunction, or young dogs from other breeds with a history of chronic recurring infections, particularly with organisms such as Aspergillus, Staphylococcus, Serratia or Burkholderia cepacia.
  • Hereditary Evaluation of Legg-Calve-Perthes Disease in Toy and Miniature Breeds  
    November 3, 2008
    Legg-Calve-Perthes Disease (LCPD) is a developmental disorder affecting the hip joint of small-breed puppies. Our study aims to identify (1) the mode of inheritance of LCPD in several small breeds and (2) candidate genes that may either cause the disease or be involved in the disease process through whole-genome association mapping.
    Dr Starr
    is looking for dogs with Legg-Calve-Perthes disease. See the trial page for specific information on eligibility.
  • Hereditary evaluation of spina bifida and cleft palate in brachycephalic dogs  
    January 20, 2009
    We hope to identify candidate genes associated with canine structural birth defects, specifically spina bifida and cleft lip/palate in the bulldog and other brachycephalic breeds. This would allow us to develop a genetic test that could identify affected dogs and carrier dogs.
    Dr Starr
    is looking for Bulldogs or brachycephalic dogs with spina bifida or labio-palatine closure defects. See the trial page for specific information on eligibility.
  • Hypertrophic Osteodystrophy (HOD): Identifying the Genes Responsible  
    December 31, 2013
    This study aims to identify the molecular cause for hypertrophic osteodystrophy. HOD is a familial disorder with an unknown etiology.
    Dr Safra
    is looking for dogs with hypertrophic osteodystrophy. See the trial page for specific information on eligibility.
  • Identification of Genetic Risk in Collies and Shetland Sheepdogs with Epilepsy  
    July 20, 2022
    Objectives: 1. Conduct a genome-wide association study (GWAS) to identify genomic regions associated with epilepsy in collies and shetland sheepdogs 2. Generate whole genome resequencing data to identify putative causal variants in associated regions.
    Dr Clark is looking for Collies and Shetland Sheep dogs with epilepsy. See the trial page for specific information on eligibility.
  • Molecular mapping and characterization of the genetic modifier associated with Collie Eye Anomaly (CEA) and Colobomas  
    July 19, 2022
    To determine genetic modifiers contributing to Coloboma formation in collies
    Dr Aguirre is looking for Collies with colobomas. See the trial page for specific information on eligibility.
  • Risk Factors for Nutritionally-mediated DCM in Healthy Dogs of 2 Size Groups: The Role of Diet Category, Taurine, Cardiac Biomarkers, and Metabolomics  
    February 19, 2024
    We hope to identify differences in cardiac parameters related to diet and/or breed size, and to investigate underlying factors that may be related to those differences.
    Drs Larsen and Stern are looking for dogs fed “grain free” diets.

  • Inflammatory/Infectious  

  • Granulomatous Disease  
    January 7, 2015
    Search For A Dog With X-Linked Chronic Granulomatous Disease
    Drs. Harry Malech and Sebastian Brenner
    Examples of canine patients that may be of value to them are young Weimaraners with recurrent infection secondary to suspected neutrophil dysfunction, or young dogs from other breeds with a history of chronic recurring infections, particularly with organisms such as Aspergillus, Staphylococcus, Serratia or Burkholderia cepacia.
  • Transcriptome Profiling of Canine Familial Dermatomyositis (DMS) Skin Lesions and Treatment in Collies and Shetland sheepdogs  
    July 20, 2022
    To evaluate the molecular signature of canine familial DMS using RNA sequencing in Collies and Shelties.
    Dr Banovic is looking for Collies and Shelties with cutaneous dermatomyositis. See the trial page for specific information on eligibility.
  • Use of Canine Struvite Dissolution Diet in the Management of Infection Induced Struvite Stones in Dogs  
    August 30, 2017
    We hope to provide another effective dietary option to struvite dissolution in dogs. By feeding the test diet (brand blinded to client) and antibiotics we expect that dissolution of canine struvite bladder stones will occur within a 12-week period.
    Dr Westropp is looking for dogs with struvite uroliths.
    See the trial page for specific information on eligibility.

  • Neoplastic  

  • Canine Mammary Tumors: Time to Second Tumor Investigation  
    June 7, 2006
    This study aims to delineate the median time from first mammary gland tumor in a dog to the second mammary gland tumor as a baseline for future mammary tumor chemoprevention trials.
    Dr Phil Bergman
    is looking for dogs that have had mammary tumor recurrence. All information is submitted via the survey form on the trial page.
  • Contrast Enhanced Imaged Guided Surgery for Cancer  
    October 28, 2011
    We hope to determine if a novel imaging system accurately delineates tumors and their margins during surgery.
    Dr Holt
    is looking for dogs with primary lung tumors, mammary tumors or soft-tissue sarcomas amenable to surgical resection. See the trial page for specific information on eligibility.

  • Neoplastic  

  • Measurement of IL-31 Levels in Dogs with Cutaneous Epitheliotropic T Cell Lymphoma: Its Association with Pruritus and the use of Lokivetmab (Cytopoint) as an Antipruritic Treatment  
    September 10, 2021
    Humans as well as dogs with cutaneous epitheliotropic T cell lymphoma (CETL) often suffer from intense itchiness which can cause significant discomfort and can affect quality of life. Can this itchiness be controlled with Cytopoint?
    Dr Souza is looking for dogs with epitheliotropic T-cell Lymphoma. See the trial page for specific information on eligibility.

  • Nutrtition  

  • Use of Canine Struvite Dissolution Diet in the Management of Infection Induced Struvite Stones in Dogs  
    August 30, 2017
    We hope to provide another effective dietary option to struvite dissolution in dogs. By feeding the test diet (brand blinded to client) and antibiotics we expect that dissolution of canine struvite bladder stones will occur within a 12-week period.
    Dr Westropp is looking for dogs with struvite uroliths.
    See the trial page for specific information on eligibility.

  • Toxic  

  • Other  

  • Identification of Genetic Risk in Shetland Sheepdogs with Gallbladder Mucocele Formation  
    December 4, 2023
    The long term goal of this research is to determine which gene(s) are responsible for predisposition of Shetland sheepdogs to mucocele formation. This will enable a better understanding of pathogenesis of mucocele formation in this breed.
    Dr. Gookin is looking for Shetland Sheepdogs with gallbladder mucocele. See the trial page for specific information on eligibility.
  • Prospective evaluation of a minimally invasive treatment option for extrahepatic biliary duct obstructions (EHBDO) in dogs and cats  
    January 14, 2015
    This FULLY FUNDED study evaluates the treatment for extra hepatic biliary duct obstruction (EHBDO) in dogs and cats using endoscopy and retrograde stenting to improve the morbidity and mortality.
    Dr Berent is looking for dogs and cats with biliary obstructions. See the trial page for specific information on eligibility.


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