Front Page VSPN Message Boards Chat Library Continual Education Search MyVSPN - Coming Soon Help Frequently Asked Questions Send us Feedback! Go to VIN Industry Partners Go to VetQuest Go to Veterinary Partner Go to Y2Spay
 
Menu bar   Go to the VIN.com Portal
 

ABSTRACT OF THE WEEK

Animals : an open access journal from MDPI
Volume 12 | Issue 6 (March 2022)

Clinical Efficacy and Safety of Malarone®, Azithromycin and Artesunate Combination for Treatment of Babesia gibsoni in Naturally Infected Dogs.

Animals (Basel). March 2022;12(6):.
Martina Karasová1, Csilla Tóthová2, Bronislava Víchová3, Lucia Blaňarová4, Terézia Kisková5, Simona Grelová6, Radka Staroňová7, Alena Micháľová8, Martin Kožár9, Oskar Nagy10, Mária Fialkovičová11
1 Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.; 2 Clinic of Ruminants, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.; 3 Institute of Parasitology, Slovac Academy of Sciences, 04001 Košice, Slovakia.; 4 Institute of Parasitology, Slovac Academy of Sciences, 04001 Košice, Slovakia.; 5 Faculty of Science, University of Pavol Jozef Šafárik, 04180 Košice, Slovakia.; 6 Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.; 7 Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.; 8 Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.; 9 Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.; 10 Clinic of Ruminants, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.; 11 Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.

Abstract

Babesia gibsoni is a tick-borne protozoal blood parasite that may cause hemolytic anemia, thrombocytopenia, lethargy, and/or splenomegaly in dogs. Many drugs have been used in management of canine babesiosis such as monotherapy or combined treatment, including diminazene aceturate, imidocarb dipropionate, atovaquone, and antibiotics. This report examines the effectiveness and safety of Malarone®, azithromycin (AZM) and artesunate (ART) combination for the treatment of babesiosis in dogs naturally infected with Babesia gibsoni. Twelve American Pit Bull Terriers were included in the experiment. Examined dogs underwent clinical and laboratory analysis including hematology and biochemistry profile and serum protein electrophoresis. After diagnosis, the dogs received combined therapy with Malarone® (13.5 mg/kg PO q24 h), azithromycin (10 mg/kg PO q24 h) and artesunate (12.5 mg/kg PO q24 h) for 10 days. The combined treatment improved hematology and biochemical parameters to the reference range gradually during the first 14 days already, resulting in the stable values until day 56 after treatment. No clinically apparent adverse effects were reported during treatment and monitoring. No relapses of parasitemia were detected in control days 180, 360, 540 and 720 in all dogs. Results of the study indicate that the combined treatment leads to successful elimination of parasitemia in chronically infected dogs with B. gibsoni.

Keywords
Babesia gibsoni; Malarone®; artesunate; atovaquone; azithromycin; babesiosis; treatment;

Article Tools:
   Medline
   Email to me

Grants:
VEGA 1/0177/22 Ministry of Education, Science, Search and Sport of the Slovak Republic
VEGA 1/0314/20 Ministry of Education, Science, Search and Sport of the Slovak Republic
VEGA 1/0658/20 Ministry of Education, Science, Search and Sport of the Slovak Republic
VEGA 2/0014/21 Ministry of Education, Science, Search and Sport of the Slovak Republic

Archives Highlights:
National survey reveals elastic price sensitivity for select equine veterinary services.
Willingness-to-pay questions were presented with a payment card approach and addressed 3 common services: annual spring vaccinations, lameness examinations, and emergency colic surgeries. In a payment card approach, respondents choose from among preselected values. Respondents were asked to choose the maximum amount they would be willing to pay for each service.
Elimination Diet Trials: Steps for Success and Common Mistakes
Increasing the duration of the EDT to 8 weeks increases the sensitivity to more than 90% for the diagnosis of food allergies in dogs and cats. The time to flare upon oral challenge with the offending diet can be 7 to 14 days.
Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes.
In this review, we concisely categorize coat coloration in horses and donkeys, focusing on the biosynthesis and types of melanin involved in pigmentation. Moreover, the review explores how coat color relates to selective breeding and specific equine diseases, offering valuable insights for developing breeding strategies that enhance both the esthetic and health aspects of equine species.
Prospective randomized trial comparing relapse rates in dogs with steroid-responsive meningitis-arteritis treated with a 6-week or 6-month prednisolone protocol.
Relapses occurred in 6/20 (30%) of the 6-month protocol and 9/24 (38%) of the 6-week protocol. There was no statistical difference in the incidence risk of at least 1 relapse between the 2 groups. "Short" 6-week prednisolone protocols could be used to treat steroid-responsive meningitis-arteritis, thereby presumably reducing the duration and severity of prednisolone's adverse effects.
A review of prevention and management of castration complications
Despite castration being one of the most frequently performed elective equine surgical procedures, complication rates are high and range from severe life-threatening conditions to mild complications that are of no consequence to the horse. This article will briefly review strategies to prevent complications and surgical castration techniques before reviewing, in-depth, the following complications: excessive scrotal swelling and seroma formation, scrotal infection, septic funiculitis, septic peritonitis, haemorrhage, evisceration, omental prolapse, pyrexia, tetanus, penile trauma, hydrocele, signs of colic, and continued stallion-like behaviour.

Back Print Save Bookmark in my Browser Email this article to me. Top of Page. VSPN AOW : Clinical Efficacy and Saf...
Contact Us