Insulins for the long term management of diabetes mellitus in dogs: a review.

Canine Med Genet. February 2022;9(1):1.

Robert E Shiel¹, Carmel T Mooney²

¹ School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. robert.shiel@ucd.ie.; ² School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.

Abstract

The year 2021 marked the centenary of the isolation of a therapeutic form of insulin and its successful use in dogs. This was a landmark moment that subsequently and rapidly led to the commercial manufacture of insulin for use in humans. The impact of insulin was almost miraculous as those destined to die from their diabetes mellitus returned to life. Over the past 100 years, insulin formulations have been modified to attempt to provide a predictable and prolonged duration of action while avoiding the development of hypoglycaemia. This has led to an ever-growing variety of insulin types in human medicine, many of which have subsequently been used in dogs. The purpose of this review article is to provide an overview of available insulin types and their application to the chronic management of canine diabetes mellitus.

Keywords

Diabetes mellitus; Dogs; Insulin; Pharmacology;

Article Tools:

Medline

Email to me

Comments:

Erratum In Canine Med Genet. 2022 Mar 4;9(1):3. doi: 10.1186/s40575-022-00115-8

Archives Highlights:

How to plan and provide general anesthesia for a troop of 98 hamadryas baboons (Papio hamadryas) for contraceptive and preventative health interventions.
A group of 12 veterinarians, 2 zookeepers, and 6 volunteers anesthetized all animals within 2 days. The baboons were orally premedicated with midazolam (0.1 to 0.5 mg/kg) and anesthetized with medetomidine (40 to 60 µg/kg, IM) and ketamine (2 to 4 mg/kg, IM); isoflurane at rates of 1.5% to 2% was used for maintaining anesthesia if necessary. For population management, the animals received a contraceptive implant (adult females), orchiectomy (young males), or vasectomy (breeding males).

"My Bitch Is Empty!" An Overview of the Reasons for Pregnancy Loss in Dogs.
If embryonic death occurs before day 35 of gestation, the embryo is absorbed. Fetal death in the second half of gestation leads to abortion or fetal emphysema, maceration, or mummification.

Cryptorchidism in dogs and cats presented for elective gonadectomy: A descriptive cohort study of 306 animals treated between 2018 and 2023.
5,476 dogs and 11,559 cats were presented to the same facility for elective surgical castration, suggesting a cryptorchid incidence of 3.21 % for dogs and 1.12 % for cats. Cryptorchid testes were more commonly observed in the inguinal area than in the abdomen, and were more frequently located unilaterally on the right side in both dogs and cats.

Aseptic protocol breaches are common among veterinary students scrubbing, gowning, and gloving into surgery.
At least 1 aseptic protocol breach (APB) was noted in 46.3% of the 96 procedures observed. The most common mistakes noted were contact of the sterile towel onto nonsterile surfaces (17.7%), contact of the gown with nonsterile surfaces (17.7%), touching sterile objects with bare hands (12.5%), and improper scrubbing technique (17.4%).

Use of Dog Serologic Data for Improved Understanding of Coccidioidomycosis: A One Health Approach.
The overall seropositivity rate among tested dogs was 37.6%. Average test positivity rates in states with =0.5 tests per annum per 10,000 households were 35.4% (Texas) to 74.1% (Montana). For these states, average annual incidence per 10,000 households was as follows: Arizona (86.8), New Mexico (0.89), Nevada (0.78), California (0.75), Montana (0.63), Colorado (0.41), Oregon (0.41), Texas (0.38), Idaho (0.37), Wyoming (0.34), Utah (0.32), and Washington (0.26). Human incidence in California and Arizona between 2012 and 2022 was significantly correlated with dog incidence.