Canine coat pigmentation genetics: a review.

Anim Genet. February 2022;53(1):3-34.

L Brancalion¹, B Haase², C M Wade³

¹ Faculty of Science, School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, 2006, Australia.; ² Faculty of Science, School of Veterinary Science, University of Sydney, Camperdown, NSW, 2006, Australia.; ³ Faculty of Science, School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, 2006, Australia.

Abstract

Our understanding of canine coat colour genetics and the associated health implications is developing rapidly. To date, there are 15 genes with known roles in canine coat colour phenotypes. Many coat phenotypes result from complex and/or epistatic genetic interactions among variants within and between loci, some of which remain unidentified. Some genes involved in canine pigmentation have been linked to aural, visual and neurological impairments. Consequently, coat pigmentation in the domestic dog retains considerable ethical and economic interest. In this paper we discuss coat colour phenotypes in the domestic dog, the genes and variants responsible for these phenotypes and any proven coat colour-associated health effects.

Keywords

albinism; coat colour; deafness; dog; melanocyte; melanogenesis; pigmentation;

Article Tools:

Medline

Email to me

Comments:

Erratum In Anim Genet. 2022 Jun;53(3):474-475

Archives Highlights:

Risk Factors for Injury in Border Collies Competing in Agility Competitions.
The jump height relative to the shoulder height was associated with injury, with dogs jumping noticeably above or below shoulder height more likely to report a history of injury. Other identified risk factors included the number of weekends spent competing/year, the number of competitions at the national level, the age when starting elbow height jumps and backside jumps, the acquisition of the dog from a breeder, and the age of the handler.

Limb amputation for feline appendicular bone tumors results in excellent recovery outcomes and high owner satisfaction with a low incidence of complications.
Time to return to walking without support was < 3 days in 69.7% of cats and 3 to 7 days in 16.7%. Activity level changes were reported as no change in 75.8% of cats. There were no behavioral changes in 92.3% of cats. Quality of life following amputation was recorded as excellent in 82.4% of cats. Owner satisfaction was reported as very satisfied, moderately satisfied, or satisfied in 98.5% of cats.

Association between highly pathogenic avian influenza outbreaks and weather conditions in Japan.
We found that higher average air temperatures two to three weeks prior, lower average wind speeds four weeks prior, and longer sunlight hours two and four weeks prior to outbreaks were significantly associated with increased risk of HPAI outbreaks in Japan. These results suggest that weather may influence environmental survival and transmission of the virus, as well as patterns of wild bird movement that could seed new outbreaks.

Effective treatment with afoxolaner (NexGard) of Trixacarus caviae in a pet guinea pig.
The animal was treated with a single oral dose of 2.50 mg/kg afoxolaner, and the lesions, presence/absence of mites, and intensity of pruritus were evaluated periodically until 2 months post-treatment. A week after the medication, the lesions were milder, but pruritus was still present and was attributed to the healing process. Further examinations showed significant improvement with the complete remission of clinical signs and no mites at the microscopic examination after 4 weeks.

Cryptorchidism in dogs and cats presented for elective gonadectomy: A descriptive cohort study of 306 animals treated between 2018 and 2023.
5,476 dogs and 11,559 cats were presented to the same facility for elective surgical castration, suggesting a cryptorchid incidence of 3.21 % for dogs and 1.12 % for cats. Cryptorchid testes were more commonly observed in the inguinal area than in the abdomen, and were more frequently located unilaterally on the right side in both dogs and cats.