Malignancy Markers in Canine Histiocytoma
World Small Animal Veterinary Association World Congress Proceedings, 2004
Sorina Iacob, Dombay E., C. Catoi, A.I. Baba, A. Gal
Faculty of Veterinary Medicine Cluj-Napoca

The mesenchymal tumors, are relatively frequent in different animal species, with higher incidence in pet. The establishment of certain markers for evaluating the malignant or the benign behavior of the histiocytoma represents a very important factor for the therapy strategies.1, 2

The material of present study was represented by 120 neoplasm formations, those were examined in course of two years at the Department of Pathology of the Veterinary Faculty-Cluj. There were 30% (36) tumors of soft connective tissue from these being selected the histiocytic tumors (8 cases). There were described the microscopic characters: vascularization, cytologic aspects. The evaluation of the malignancy parameters was made as follows: the mitotic rate was estimated by the classic method of counting at least 100 nuclei and expressing the mitoses percentage. The mean nucleolus/nuclei number was obtained by counting the nucleoli number in at least 100 nuclei; the nuclear organizers were counted in at least 100 nuclei.

Results

Case No.1: Husky, female, 6 month old. Diagnosis: benign histiocytic tumor. Mitotic rate was 0,54%; the mean number of nucleolus/nucleus was 1,15; the mean number of Ag-NOR/nucleus it was 1,27. Case No.2: mixed bread, female, 1,5 years old. Diagnosis: benign histiocytic tumor. Mitotic rate was 0,52%; the mean number of nucleolus/nucleus was 1,10; the mean number of Ag-NOR/nucleus was 1,24. Case No.3: Boxer, female, 8 years old. Diagnosis: malignant histiocytosis. Mitotic rate was 2,10%; the mean number of nucleolus/nucleus was 1, 60; the mean number of Ag-NOR/nucleus was 6,45. Case No.4: Boxer, female, 8 months old.

Diagnosis

Malignant histiocytosis. Mitotic rate was 2,11 %; the mean number of ucleolus/nucleus was 1,46; the mean number of Ag-NOR/nucleus was 6, 55. Case no.5: Boxer, male, 9 years old. Diagnosis: malignant histiocytosis. Mitotic rate was 2,16%; the mean number of nucleolus/nucleus was 1, 41; the mean number of Ag-NOR/nucleus was 4, 52. Case no.6: mixed bread, male, 2 years old, cutaneous tumor from the left periorbital zone. Diagnosis: malignant histiocytosis. Mitotic rate was 1, 66%; the mean number of nucleolus/nuclei was 1,83; the mean number of Ag-NOR/nucleus was 4, 20. Case no.7: Pitt-Bul, female, 7 years old. Diagnosis: malignant histiocytosis. Mitotic rate was 2, 77%; the mean number of nucleolus/nuclei was 1,58; the mean number of Ag-NOR/nucleus was 5,88. Case no.8: English bulldog, male, 9 years old. Diagnosis: malignant histiocytosis. Mitotic rate was 2,77%; the mean number of nucleolus/nuclei was 1, 22; the mean number of Ag-NOR/nucleus was 5,74.

Conclusions

Mitotic index and the average number of nucleolar organizers/nucleus were higher in malignant tumors. There was a relative positive correlation between mitotic index and the number of nuclear organisators, a very useful marker for revealing the malignancy. The estimation of nucleolar organizators' number could be used as a parameter in order to appreciate the malignant character of tumors of the mesenchymal tissues.

References

1.  Affolter, V.K. et al 2002: Vet. Path. 39 (1): 74 -EndChk_ 83.

2.  Baba A.I. 2002 -Oncologie comparată, Ed. Academiei Române, Bucharest.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

C. Cătoi
Faculty of Veterinary Medicine Cluj-Napoca
Romania


MAIN : Abstracts : Canine Histiocytoma
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.

CONTACT US

777 W. Covell Blvd., Davis, CA 95616

vingram@vin.com

PHONE

  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357
SAID=27