Electrochemotherapy - Alternative Treatment of Perianal Tumours in Dogs
World Small Animal Veterinary Association World Congress Proceedings, 2004
N Tozon1, V Kodre2, G Serša3, M Čemažar3
1University of Ljubljana, Veterinary Faculty, Small Animal Clinic, Slovenia; 2Janssen-Cilag, Slovenia; 3Institute of Oncology, Slovenia

Introduction

Electrochemotherapy is an antitumor therapy that utilizes locally delivered short intense direct current electric pulse to the tumour nodule and chemotherapy. The aim of the present study was to evaluate the electrochemotherapy treatment of perianal tumours of different sizes in dogs.

Material and methods

Between March 2000 and July 2003, 12 patients with all together 26 measurable cutaneous were included in the study. Before treatment, the dogs were sedated. Electrochemotherapy consisted of intratumoral administration of cisplatin at a dose of approx. 1 mg/cm3 tumour volume, followed by application of electric pulses to the tumour. If the treatment with cisplatin as the first chemotherapeutic drug was not successful, electrochemotherapy with bleomycin was performed, with bleomycin at a dose of approx. 3 mg/1 cm3 tumour volume. Square wave electric pulses of 100 μsec, 910 V amplitude (amplitude to electrode distance ratio 1300 V/cm), frequency 1 Hz were delivered through two parallel stainless steel electrodes (thickness 1mm; width 7mm, length 8mm, with rounded tips and an inner distance between them 7 mm) with an electroporator Jouan GHT 1287. Each run of electric pulses was delivered in two trains of four pulses, with 1s interval, in two perpendicular directions. The interval between cisplatin or bleomycin administration and the application of electric pulses was 1-2 min. The treatment response was evaluated according to WHO classification (complete response (CR); partial response (PR); no change (NC) and progressive disease (PD)). The number of objective responses (OR) was determined by combining the number of CR and PR.

Results

Responses to treatment were assessed 4 weeks after the therapy, 82% of all tumors treated with electrochemotherapy responded with objective response (OR) (complete response (CR) = 41%, partial response (PR) = 41%), 16% responded with no change (NC) and one tumor (2%) went in progressive disease (PD). At the end of observation period for each tumor ranging from 1 to 34 months, 92% of OR (CR=65%, PR=27%), 8% of NC and no PD were obtained. To achieve above-mentioned results, average number of electrochemotherapy sessions was 1.6 and in range from 1 to maximum 4 sessions per patient. There were no major local or general side effects noted.

Conclusions

This study shows that electrochemotherapy with cisplatin or bleomycin is an effective treatment of perianal tumours in dogs. The advantages of this therapy are it's simplicity, short duration of treatment sessions, low chemotherapeutic doses, and insignificant side effects, as well as the fact that it can be performed on outpatient basis.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

N Tozon
University of Ljubljana, Veterinary Faculty
Small Animal Clinic, Slovenia


MAIN : Abstracts : Electrochemotherapy
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.

CONTACT US

777 W. Covell Blvd., Davis, CA 95616

vingram@vin.com

PHONE

  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357
SAID=27