Cardiovascular Effects of Anaemia in the Cat - An Echocardiographic Study
World Small Animal Veterinary Association World Congress Proceedings, 2004
J. Sottiaux, DECVIM-CA (Cardiology)
Animal Medical Centre Referrals, Manchester, UK

With the exception of one case of reversible left ventricular dilatation in a kitten, there is little information on the consequences of severe anaemia on the intact heart in cats. This study was designed to evaluate the impact of anaemia on the diastolic and systolic function of the right ventricle (RV) and left ventricle ( LV ) and to determine the patterns of cardiac remodeling associated with this condition.

10 cats with moderate to severe anaemia (haemoglobin < 7 gr/dl; hematocrit < 21% ) and signs of cardiac involvement ranging from heart murmur to overt heart failure were included in this study. Normality for distribution of all parameters was checked using the Kolmogorov-Smirnov test. Each parameter was compared with the reference values obtained from healthy patients in our hospital using the Mann-Wittney rank-sum test.

All patients were euthyroid. The systolic blood pressures were within normal range (110-145 mm Hg). 7 patients had a high LV output (>245 ml/kg/mn). High LV output resulted from stroke volume augmentation (4.4 +/-1.2 ml versus 2.7+/-0.6 ml. p: 0.001). LV systolic hyperfunction was indicated by the increased fractional shortening (52+/-11% versus 40+/-7%. p: 0.009) which resulted from a hyperkinetic state. Hyperkinetic state was demonstrated by the increased systolic thickness of the septum ( 0.64+/-0.11 cm versus 0.51+/-0.09 cm. P: 0.01) and of the LV free wall (0.82+/-0.11 cm versus 0.59+/- 0.07 cm.p: 0.001 ). The significant prolongation of the pulmonary flow acceleration time ( 59+/-19 ms versus 44+/- 6 ms. P<0.001 ) suggested a depressed RV systolic function. There was no significant change in the LV diastolic and systolic diameter. Cardiac remodeling consisted of significantly increased LV free wall thickness ( 0.54+/- 0.08 cm versus 0.40+/-0.06 cm. p: 0.003 ) with free wall hypertrophy ( > 0.55 cm ) in 4 patients. Follow-up of the patients with LV wall hypertrophy showed decreasing wall thickness, increasing LV diastolic and systolic diameter, and prolongation of the LV pre-ejection period with the correction of anaemia.

The adaptive response of the intact heart to severe anaemia consist of reversible LV hypertrophy and systolic hyperfunction with a decreased peak systolic wall stress. The RV appears to be more vulnerable to the hypoxia generated by severe anaemia.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

J. Sottiaux, DECVIM-CA (Cardiology)
Animal Medical Centre Referrals
Manchester, UK


MAIN : Abstracts : Cardiovascular Effects of Anaemia in the Cat
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.

CONTACT US

777 W. Covell Blvd., Davis, CA 95616

vingram@vin.com

PHONE

  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357
SAID=27