Buprenorphine Cardiovascular Effects in Dogs Anesthetized with Desflurane
WSAVA 2002 Congress
*Almir Pereira de Souza, Márlis Langenegger de Rezende, Newton Nunes, Paulo Sérgio Patto dos Santos, Celina Tie Nishimori, Alessandra Valeiro Leite
*Universidade Estadual Paulista - FCAV - Jaboticabal, Via de acesso Prof. Paulo Donato Castellane s/n° - zona rural
Jaboticabal, São Paulo, SP BR
apsouza@fcav.unesp.br

OBJECTIVES

The purpose of this study was to evaluate the possible cardiovascular alterations that may occur due to the use of buprenorphine in dogs anesthetized with desflurane.

MATERIALS

Eight adult healthy male and female mongrel dogs were used. The anesthetic induction was made using propofol (IV), and immediately after, the dogs were intubated and the tube was connected to a volatile anesthetic circuit, and desflurane was administrated at 1.5 MAC. During the experimental period, the dogs were maintained under controlled ventilation. After 15 minutes of anesthesia, the dogs received buprenorphine (0.02 mg/kg/IV). Heart rate (HR); systolic, diastolic and mean arterial blood pressure (SAP, DAP, and MAP, respectively); cardiac output (CO), central venous pressure (CVP) and pulmonary arterial pressure (PAP) were evaluated. The measurements were realized 20 minutes after induction (M1), 15 minutes after buprenorphine administration (M2); and at each 15 minutes after M2 (M3, M4 and M5). The numerical data were submitted to Tukey test (p<0.05).

RESULTS

After buprenorphine administration (M2), there was a reduction in cardiovascular values: HR, PAP, SAP, DAP and MAP. During all the study, these values remained lower than the initial values, but were within normal values to the species. The CO and CVP were also decreased, but not statistically significant.

CONCLUSION

The results allow us to conclude that buprenorphine reduces the cardiovascular values in dogs during desflurane anesthesia.

Speaker Information
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Márlis Langenegger de Rezende
Universidade Estadual Paulista - FCAV - Jaboticabal
Via de acceso Prof. Paulo Donato Castellane s/n° - zona rural
Jaboticabal, SP 14884-900 BR

Newton Nunes
Universidade Estadual Paulista - FCAV - Jaboticabal
Via de acesso Prof. Paulo Donato Castellane s/n° - zona rural
Jaboticabal, São Paulo/ SP 14884-900 BR

Almir Pereira de Souza
Universidade Estadual Paulista - FCAV - Jaboticabal
Via de acesso Prof. Paulo Donato Castellane s/n° - zona rural
Jaboticabal, São Paulo/ SP 14884-900 BR

Paulo Sergio Patto dos Santos
Universidade Estadual Paulista - FCAV - Jaboticabal
Via de acceso Prof. Paulo Donato Castellane s/n° - zona rural
Jaboticabal, SP 14884-900 BR

Celina Tie Nishimori
Universidade Estadual Paulista - FCAV - Jaboticabal
Via de acesso Prof. Paulo Donato Castellane s/n° - zona rural
Jaboticabal, São Paulo/ SP 14884-900 BR

Alessandra Valeiro Leite
Universidade Estadual Paulista - FCAV - Jaboticabal


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