David A. Wilkie, DVM, MS, DACVO
The Ohio State University Veterinary Hospital Dept.
Columbus, OH, USA
All corneal lesions result in a decrease in the transparency of the cornea. There are only 4 basic changes that can result in a change in corneal transparency:
1. Edema
2. Pigmentation
3. Scar
4. Infiltrate
a. Cellular
b. Non-cellular or crystalline
Corneal Edema
Edema is of 2 types, focal and diffuse.
Focal--is generally the result of a corneal ulcer. Diagnosis is by fluorescein dye.
Diffuse--is generally due to endothelial damage. The cornea is fluorescein negative. The etiologies for diffuse corneal edema are:
Anterior uveitis
Glaucoma
Trauma
Breed related in the Chihuahua and Boston terrier (endothelial dystrophy)
Anterior lens luxation
Intraocular pressure should be measured in all eyes with diffuse corneal edema.
Corneal Pigmentation
Pigmentation will result from any form of chronic superficial irritation. It is usually associated with corneal vascularization. Exceptions to this include:
Corneal Sequestration--Cat
Unique to cats. Seen more frequently in the brachycephalic (esp. Persians and Himalayans) cats. It occurs following chronic irritation or ulceration of the cornea and appears as a brown-black corneal lesion. If you see a black lesion on the cornea of a cat it is probably a sequestrum.
Painful, often vascularized, fluorescein negative. Has been associated with herpes keratitis. As the name suggests this is like any other sequestrum, it is a walled off area of dead tissue.
Treatment
1. Superficial keratectomy +/- supportive grafting techniques
2. Topical antibiotics, atropine, and artificial tears following surgery
3. Antiviral therapy
Melanoma
Intra- or extraocular (epibulbar (limbal) melanoma).
Corneal Scar
The diagnosis of a scar is made based on the history, presence of vascularization, and lack of pain.
Corneal Infiltrate
Cellular Infiltrates
These include:
Neoplasia
Generally rare--varies with the species, but in general squamous cell carcinoma (horse, cow, cat) and lymphosarcoma (all species) are the most common.
Non-Neoplastic
Abnormalities such as a dermoid or epithelial inclusion cyst
Inflammatory
Several specific diseases:
Fibrous histiocytoma [Nodular Granulomatous Episclerokeratitis (NGE)]
Non-neoplastic, inflammatory mass of the dog. Proliferative pink corneal mass usually at the temporal limbus in one or both eyes. Masses are subepithelial infiltrates of lymphocytes, plasma cells, and histiocytes. Most commonly seen in cocker spaniels, collies and collie crosses, pugs.
Therapy:
1. Topical steroids--(dexamethasone 0.1% qid) initial treatment--not all are responsive
2. Topical cyclosporine or tacrolimus
3. Systemic azathioprine (Imuran ®) (2 mg/kg qd until remission then taper)--use if topical Dex does not control--need biweekly CBCs to monitor leukopenia
Chronic Superficial Keratitis (Pannus)
Previously called German shepherd or degenerative pannus. This is an immune-mediated disease that begins at the inferior temporal limbus. It results in corneal vascularization and pigmentation that will, if not controlled, advance across the entire cornea. German shepherds and their crosses are predisposed.
Therapy:
1. There is no cure, only control
2. Topical corticosteroids are the therapy of choice. Begin 4-6 x/day with topical 0.1% dexamethasone and taper to 1-2x/day as the disease is controlled. Therapy is life long.
3. Topical cyclosporine or tacrolimus
4. Decrease the dog's exposure to UV light as this seems to exacerbate the condition
Eosinophilic Keratitis
Unique to the cat and horse. Pink-red, raised lesion with a superficial white plaque that invades from the limbus and is non-painful. Uni- or bilateral. Diagnosis: cytology obtained by corneal scraping yields mast cells and/or eosinophils. This is pathognomonic.
Treatment:
1. Topical corticosteroids: 0.1% dexamethasone 4-6x/day for 7 days then as needed to control the lesion. Therapy may be for life, but you should attempt to wean off the steroids at 2-3 months to see if the condition reoccurs.
2. If corticosteroids do not control the lesion or it reoccurs while on corticosteroids, then megestrol acetate (Ovaban®) is the therapy of choice: 5 mg/cat SID for 4-7 days then rapidly taper the dose to a maintenance level of 1.25-2.5 mg/cat/week. (The side effects with Ovaban® include weight gain, mammary gland hyperplasia and neoplasia, diabetes mellitus, pyometra, and behavior changes.)
Non-cellular Corneal Infiltrates
These are infiltrates of crystalline material such as cholesterol or mineral. They often appear birefringent. They can be primary or secondary.
Primary
Corneal dystrophy. These are non-painful, non-vascularized, often bilateral, and occur in predisposed breeds. No treatment is required (See Table 1).
Secondary
Corneal degeneration, the result of previous corneal inflammation (look for blood vessels) or associated with systemic diseases such as:
Hypothyroidism
Hypercholesterolemia of Cushing's
Hypercalcemia
Diabetes mellitus
Chronic topical or systemic corticosteroids
Again no ocular treatment is required, but the systemic disease, if present, must be diagnosed and treated. The corneal lesion should regress with time if the initiating problem is corrected.
Table 1. Examples of corneal dystrophy in the dog.
Breed |
Inheritance |
Age of onset |
Appearance |
Airedale |
Sex-linked |
4-12 months |
Anterior stroma, central, lipid |
Alaskan malamute |
None or unknown |
2 yrs and older |
Para central, similar to beagle |
Beagle |
None or unknown |
|
Paracentral, stromal. Nebular, race track, white arc |
Boston terrier |
Familial |
5-9 yrs |
Corneal edema, endothelial dystrophy |
Chihuahua |
Familial |
6-13 yrs |
Corneal edema, endothelial dystrophy |
American cocker spaniel |
Unknown |
|
Posterior polymorphous dystrophy |
Dachshund |
Unknown |
8-11 yrs |
Corneal edema, endothelial dystrophy |
Collie |
Unknown |
1-4 yrs |
Subepithelial lipid deposits |
Samoyed |
Suspected |
6 months-2 yrs |
Gray round to oval (doughnut-shaped) opacity, stromal dystrophy |
Shetland sheepdog |
Unknown |
2-4 yrs |
Multiple gray-white circular rings, superficial erosions |
Siberian Husky |
Recessive with variable expression |
|
Gray round to oval (doughnut-shaped) opacity, stromal dystrophy |