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Heartworm Preventive Comparison Chart for Dogs and Cats

Date Published: 01/01/2001
Date Reviewed/Revised: 11/21/2019

Confused about heartworm prevention options? These two charts compare current heartworm preventive products side by side to assist you in determining which is right for your situation.

In the second chart, LD50 stands for lethal dose to 50 percent of a population. Typically lethal doses are expressed as oral (toxin taken by mouth) or by dermal (toxin placed on the skin). LD50s are usually determined with lab animal species such as rats, mice, and rabbits, but occasionally information is available for dogs. LD50s are expressed in milligrams of ingredient per kilogram of animal body weight (i.e. mg/kg) and provides a way to compare the toxicity of different substances.

The higher the LD50, the less toxic a substance is. Some of the materials reviewed here are so safe that LD50 has not been determined and we can only say that it is greater than a certain amount tested. The highest numbers represent the safest numbers.

 

For
Dogs or Cats

Heartworm Preventing Ingredient

Other Ingredients for Control of Other Parasites

Other Parasites Controlled

Mode of Application

Youngest Age to Start Using

Heartgard
for Dogs

Dogs

Ivermectin

None

None

oral

6 weeks

Heartgard Plus
Iverhart Plus
Iverhart Max
Triheart Plus
Pet Trust Plus

Dogs

Ivermectin

pyrantel
pamoate
Iverhart Max also
has praziquantel

hookworms, roundworms
Iverhart Max also covers tapeworms

oral

6 weeks

Heartgard
for Cats

Cats

Ivermectin

None

hookworms

oral

6 weeks

Interceptor
Interceptor Plus
MilbeGuard

Dogs
and Cats

Milbemycin Oxime; Interceptor Plus also has praziquantel

None

hookworms, roundworms, whipworms;
Interceptor Plus covers tapeworms 

oral

4 weeks
for puppies
6 weeks
for kittens

Sentinel
Sentinel Spectrum

Dogs

Milbemycin Oxime

Lufenuron
Sentinel Spectrum also has praziquantel

hookworms, roundworms, whipworms, sterilizes fleas
Sentinel Spectrum also covers tapeworms

oral

4 weeks

Revolution

Dogs
and Cats

Selamectin

None

For dogs: fleas, ticks, ear mites, sarcoptic mange mites
For Cats:  fleas, ear mites, hookworms, roundworms

topical

6 weeks
for puppies
8 weeks
for kittens

Advantage Multi

Dogs
and Cats

Moxidectin

Imidocloprid

For dogs: fleas, hookworms, roundworms, whipworms
For Cats: fleas, ear mites, hookworms, roundworms

topical

7 weeks
for puppies
9 weeks
for kittens

Proheart6
Proheart 12

Dogs

Moxidectin

None

hookworms

injectable

6 months for Proheart6, 12 months for Proheart12

Trifexis

Dogs

Milbemycin Oxime

Spinosad

fleas, hookworms, roundworms, whipworms

oral

8 weeks

    

 

How Often Used

Approved for Pregnancy and Lactation?

Water-proof?

Safe to Give to Heartworm Positive Animal?

Manufacturer Website

LD50

Heartgard

Monthly

yes

yes

yes

Heartgard

10 mg/kg in rats orally according to MSDS sheet for Parade Equine Gel

Heartgard Plus
Iverhart Plus
Triheart Plus
Pet Trust Plus

monthly

yes

yes

yes

Heartgard Plus
Iverhart Plus
Triheart Plus
PetTrustPlus

10 mg/kg in rats orally for ivermectin; >690 mg/kg in dogs orally for Pyrantel Pamoate according to The Elephant Formulary by Mikota and Plumb

Heartgard
for Cats

monthly

yes

yes

yes

Heartgard

10 mg/kg in rats orally

Interceptor
Interceptor Plus
MilbeGuard

monthly

yes

yes

In most cases yes but if microfilariae numbers are high then no

Interceptor
Interceptor Plus
MilbeGuard

LD50 information unavailable

Symptoms of tremors and incoordination result at 19 times recommended dose

Sentinel
Sentinel Spectrum

monthly

yes

yes

In most cases yes but if microfilariae numbers are high then no

Sentinel

LD50 information unavailable

Symptoms of tremors and incoordination result at 19 times recommended dose

Revolution Plus

monthly

yes

yes

yes

Revolution Plus

>1600 mg/kg in the rat orally

Advantage Multi

monthly

no

no

yes

Advantage
Multi

Moxidectin: 106 mg/kg orally;
Imidocloprid: 450 mg/kg in the rat orally

Proheart6
Proheart 12

every 6 months for Proheart6,
every 12 months for Proheart12

yes

yes

Zoetis recommends caution if used in heartworm positive dogs.

Proheart6

263 mg/kg in the rat when given by injection (the dose used therapeutically is 0.17mg/kg)

Trifexis

monthly

Manufactuer cautions use, says to discuss with your veterinarian

yes

In most cases yes but if microfilariae numbers are high then no

Trifexis

Milbemycin Oxime: LD50 information unavailable Spinosad: >3,000 mg/kg in rats; >2,000 mg/kg in rabbits (translates to over 30 times recommended dose)

   

These products are available in the U.S. Pet owners in other countries should discuss options with their veterinarian. 



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