Periparturient Distal Limb Swelling and Periosteal Reaction in Sichuan Takin (Budorcas taxicolor tibetana): 5 Cases of Presumptive Hypertrophic Osteopathy
Hypertrophic osteopathy is a syndrome characterized by painful distal limb swelling and periosteal proliferative reaction, typically of the metacarpal and metatarsal bones and phalanges.3 Lesions are often bilaterally symmetric and affect all four limbs.12 While primarily observed in dogs and people, several cases have been reported in exotic ruminants.2,4,6,8 Hypertrophic osteopathy is frequently associated with primary intra-thoracic disease, but this condition has also been reported secondary to intra-abdominal and intra-pelvic disease.5,9,10 The syndrome has also been associated with pregnancy in both people and horses.1,7 Over a 20-year period, five adult female Sichuan takin (Budorcas taxicolor tibetana), with 13 total pregnancies, were evaluated for lameness and distal limb swelling. Clinical signs were observed between 2 and 32 days (mean=18.6 days) prior to parturition (gestation period in takin approximately 220 days)11 and resolved in all animals following birth. Lameness and limb swelling resolved between 8 and 168 days (mean=39.1 days) after birth. Fifteen radiographic examinations, from four individuals, showed periosteal proliferative reaction, primarily of the metacarpal bones, metatarsal bones, and phalanges. Serial radiographs in three takin showed resolving periosteal reaction following parturition. The clinical progression, resolution of signs, and radiographic findings in these cases are consistent with hypertrophic osteopathy, secondary to pregnancy. This is the first report describing presumptive hypertrophic osteopathy in takin.
The authors thank Dr. Andrea Aplasca for her assistance with this project.
1. Cullen DR, Maskery PJK. Clubbing of the fingers and hypertrophic osteoarthropathy in pregnancy. Lancet. 1966;473–475.
2. Curtis C, Dart AJ, Rawlinson RJ, Hodgson DR. Hypertrophic osteopathy in an alpaca. Aust Vet J. 1997;75(1):61–62.
3. Dunn ME, Blond L, Letard D, DiFruscia R. Hypertrophic osteopathy associated with infective endocarditis in an adult boxer dog. J Small Anim Pract. 2007;48:99–103.
4. Ferguson NM, Levy M, Ramos-Vara JA, Baird DK, Wu CC. Hypertrophic osteopathy associated with mycotic pneumonia in two juvenile elk (Cervus elaphus). J Vet Diagn Invest. 2008;20:849–853.
5. Grillo TP, Brandao CVS, Mamprim MJ, de Jesus CMN, Santos TC, Minto BW. Hypertrophic osteopathy associated with renal pelvis transitional cell carcinoma in a dog. Can Vet J. 2007;48:745–747.
6. Kenny DE, Getzy DM, Eller JL, Morgan T. Osteoarthropathy in a blesbok (Damaliscus dorcas phillipsi). J Zoo Wildl Med. 1997;28(3):319–324.
7. Lavoie JP, Carlson GP, George L. Hypertrophic osteopathy in three horses and a pony. J Am Vet Med Assoc. 1992;201(12):1900–1904.
8. Madson DM, Loynachan AT, Kariyawasam S, Opriessnig T. Systemic Conidiobolus incongruus infection and hypertrophic osteopathy in a white-tailed deer (Odocoileus virginianus). J Vet Diagn Invest. 2009;21:167–170.
9. Peeters D, Clerex C, Thiry A, Hamiade A, Snaps F, Henroteaux M, Ogilvie GK, Day MJ. Resolution of paraneoplastic leukocytosis and hypertrophic osteopathy after resection of a renal transitional cell carcinoma producing granulocyte-macrophage colony-stimulating factor in a young bull terrier. J Vet Intern Med. 2001;15:407–411.
10. Schleining JA, Voss ED. Hypertrophic osteopathy secondary to gastric squamous cell carcinoma in a horse. Equine Vet Educ. 2004;16(6):304–307.
11. Stuwe M, Grodinsky C. Reproductive biology of captive Alpine ibex (Capra ibex). Zoo Biol. 1987;6:331–339.
12. Withers SS, Johnson EG, Culp WTN, Rodriguez Jr CO, Skorupski KA, Rebhun RB. Paraneoplastic hypertrophic osteopathy in 30 dogs. Vet Comp Oncol. 2015;13(3):157–165.