Outcomes of Hemodialysis in Chronic Kidney Disease Dogs with Uremic Crisis Situations
Kasetsart University Veterinary Teaching Hospital, Veterinary Medicine Faculty, Kasetsart University, Bangkok, Thailand
Uremic situations commonly develop in chronic kidney disease dogs. The complications associated with uremia including seizure, pneumonitis, cardiac arrest are situations that can shorten CKD patient life. The hemodialysis is used to eliminate the uremic toxin and balance the electrolytes.
The study was to determine the short-term outcome for chronic renal disease dogs with uremic crisis situations treated with hemodialysis compared to conservative treatment.
The study was retrospectively reviewed from September 2017 to October 2015 at Kasetsart University Veterinary Teaching Hospital (KUVTH), Faculty of Veterinary Medicine, Kasetsart University. Medical records of 21 uremic dogs were searched and divided into 2 groups of treatment. Hemodialysis treatment (HD) group consisted of 8 dogs. Conservative treatment (CV) group consisted of 13 dogs admitted to KUVTH. Two-sample t-test and Chi-square test were performed to determine the differences of age, body weight, gender and hematologic values between two groups of treatment. Method of survival analysis with Kaplan Meier survival curve was used. The log-rank test was analyzed to determine the difference of median survival time between two groups of treatment.
Between two groups of treatment, body weight and serum creatinine of HD group were significantly higher (p<0.05) than CV group. The median survival time of uremic dogs treated with hemodialysis, 17 days (95%CI=12–19 days), was significantly different (p<0.05) from conservative treatment group, 3 days (95%CI=2-6 days).
Hemodialysis is a tool for prolonging life and improving quality of life in CKD patient with acute uremic situation.