Minimally Invasive Thermoablation as a Novel Therapy for Malignant Nasal Tumors in Two Dogs
Nasosinal tumors account for approximately 1% of all canine tumors. Thermotherapy has been a method for tumor treatment by direct killing of tumor cells with coagulative necrosis. Minimally invasive thermoablation (MITA) is a new modality that applies a high temperature on the specific part of the needle to treat target tumors.
To evaluate the effects and side effects of MITA used in treating malignant nasal tumors in dogs.
Two client-owned dogs with nasal melanoma and transitional carcinoma, respectively. MITA was performed with computed tomography scan guidance under general anesthesia every 2–3 weeks. The temperature reached 90–100°C in 60 seconds and then was maintained for 240 seconds to complete a 300-second procedure. The effective area of each needle after heating was 7.5 mm in radius from center of needle.
The dog with nasal melanoma had complete remission after twice MITA and showed no relapse for 445 days to the date of this abstract submitted. The dog with nasal transitional carcinoma had received MITA 8 times and showed partial remission with progression-free interval of 407 days. Side effects were self-limited and included sneezing, nasal discharge. No major side effects were observed.
MITA is an effective, promising treatment of canine nasal tumor with minimal side effects.