Evaluation of Factors Associated with Survival in Dogs with Lymphoma Treated with Prednisone. The Canine Lymphoma Steroid Only (CALYPSO) Open-Label Prospective Clinical Trial: 69 Cases (2016–2017)
Veterinary Cancer Society Conference 2017
Johannes, Chad1; Rassnick, Kenneth2; Bailey, Dennis3; Yanda, Nathan1; Regan, Rebecca4; Malone, Erin5; Intile, Joanne6; Kiselow, Michael7; Lucroy, Michael8; Berger, Erika1; Fox, Leslie1; Kamstock, Debra9; LeBlanc, Casey10
1Iowa State University College of Veterinary Medicine; 2The Veterinary Medical Center of Central New York; 3Oradell Animal Hospital; 4Blue Pearl Georgia Veterinary Specialists; 5MedVet Medical and Cancer Centers for Pets; 6East End Veterinary Emergency and Specialty Center; 7Sage Centers for Veterinary Specialty and Emergency Care; 8MedVet Medical & Cancer Centers for Pets; 9KamPath Diagnostics & Investigation; 10Eastern VetPath


Intermediate-to-high grade lymphomas in dogs are biologically aggressive and typically fatal within weeks if not treated. Despite inclusion of prednisone in multiagent chemotherapy protocols and frequent use of single-agent prednisone when chemotherapy is declined, only small studies with variable dosing and follow-up have evaluated benefits of corticosteroids alone. The objective of this study was to assess survival time of dogs with lymphoma treated only with a standardized steroid protocol. Factors potentially associated with prognosis also were examined.


Dogs with naïve peripheral nodal lymphoma were recruited from 15 institutions. Diagnosis was confirmed by cytology and immunophenotype established via immunocytochemistry. Dogs received prednisone at 40 mg/m2/d PO for 7 days then 20 mg/m2/d thereafter. Quality-of-life (QOL) on a scale of 0–100 was assessed by dog-owners.


Sixty-nine dogs with large-cell lymphoma met all inclusion criteria (53 B-cell, 16 T-cell). Median age and body weight were 8 years and 28.8 kg, respectively. Thirty-eight dogs were classified as substage-a, 31 as substage-b. Overall median survival was 50 days (95% CI, 39–62). Baseline QOL was correlated with survival (r=0.38; P=0.001). Median survival time for 18 dogs with QOL <50 was 27 days (95% CI, 7–51) compared to 68 days (95% CI, 55–83) for 48 dogs with QOL >/=50 (P=0.0088). Substage, phenotype, and duration of signs before diagnosis were not significant.


Dogs with peripheral nodal lymphoma treated with single-agent prednisone experience short-term survival. Baseline client-assessed QOL might be predictive of survival. Results of this study provide clinicians with meaningful considerations to discuss with owners at time of treatment decision.


Speaker Information
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Chad Johannes
Iowa State University