Evaluation of Glomerular Filtration Rate in Dogs with Renal Disease Using Serum Cystatin C
Assessment of renal function in patients with renal disease has a great importance. Various studies have reported about cystatin C as an easy and rapid assessable marker that can be used for accurate information on renal function impairment in humans lastly, but we have found only one study in dogs.
Material & Methods
For this reason in this study, the glomerular filtration rate (GFR) of 30 dogs of different breeds with a broad range of bodyweight were evaluated by using serum cystatin C to determine its usefulness as a marker. Ten dogs which formed the control group, and 20 dogs which had elevated serum creatinine levels and a low urine specific gravity due to renal disease, constituted the study material.
The range of serum cystatin C values was 1,2±0,42 mg/L in control dogs, 2,96±1,09 mg/L in dogs with azotaemic renal disease (p<0,01).
The study indicates that, endogenous markers of GFR are more advantageous such as cheap and simple, and more accurate, rapid and reliable tool for evaluating GFR in small animal practice.