Canine Uncommon Superficial Pyoderma Treated with Amoxicillin and Clavulanic Acid Association (Synulox N.D.): About Four Cases
World Small Animal Veterinary Association World Congress Proceedings, 2003
B. Hubert *; J.P. Magnol
Clinique Veterinaire Foch
Beziers, France


Canine pyoderma present very different clinical aspects which can correspond to pathogen agents, alone or associated, not very frequent or which pathogenicity is increased by previous inappropriate therapies. In this context, clavulanate-amoxicillin association (SYNULOX®) was tested for its efficacy.

Materials & Methods

Four dogs presented for a superficial pyoderma were examined.

Case 1

Female West Highland White Terrier

Generalized superficial pyoderma, pain

Proteus mirabilis

Case 2

Male English setter

Pyoderma localized to left hind limb, pain

Escherichia coli

Case 3

Male Airedale terrier

Superficial extensive dorsal pyoderma, pain

Staphylococcus intermedius Pseudomonas aeruginosa

Case 4

Female Brittany fawn griffon

Superficial extensive pyoderma, pruritus

Staphylococcus intermedius

Skin samples (for cytology, culture, antibiogram) were performed at D0, D21, D45. A biopsy was performed at D0. The treatment consisted of an antibiotherapy with amoxicillin and clavulanic acid (12,5 mg/kg twice daily during 45 days)


Cases 1, 2 and 4 presented a great clinical improvement on day10 and clinical and bacteriological recovery on day 45. Case 3 showed improvement on Day 21 and recovered on Day 60.


Amoxicillin and clavulanic acid can be used for treatment of chronic and unusual superficial pyoderma, provided that the duration of treatment is at least 45 days. In case 3, the improvement can be explain by the sterilization of the strain of Staphylococcus intermedius and the suspension of corticotherapy which, by modifying the microbial flora of the pyoderma, permitted in an indirect way, an action on Pseudomonas aeruginosa.

Speaker Information
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B. Hubert
Clinique Veterinaire Foch
Beziers, France

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