Cutaneous Lymphoma in a Spangled Ebony Langur (Trachypithecus auratus auratus) and Attempted Treatment with Masitinib
2018 Joint EAZWV/AAZV/Leibniz-IZW Conference
Antoine Leclerc1, DVM, DECZM (ZHM); Karin Lemberger2, DACVP; Didier Pin3, DVM, DECVD; Nicolas Goddard1, DVM; Amélie Nicolau1, DVM; Alice Brunet4, DVM; Océane Graillot1, DVM; Baptiste Mulot1, DVM
1ZooParc de Beauval & Beauval Nature, Saint-Aignan, France; 2Vet Diagnostics, Lyon, France; 3VetAgro Sup, UP Interactions Cellules Environnement, Université de Lyon, Marcy l’Etoile, France; 4Réserve Zoologique de la Haute Touche, Muséum National d’Histoire Naturelle, Obterre, France


A 14-month-old female Spangled Ebony Langur (Trachypithecus auratus auratus) was presented for circular, erythematous, crusty lesions of the inguinal skin. General condition and appetite were good. Skin scrapings, touch preparations and bloodwork revealed no abnormality.

Lesions extended and became ulcerative. Bacteriology yielded positive culture for Staphylococcus aureus, and treatment with antibiotics and steroids was attempted, in addition to topical antisepsis. Skin biopsies revealed a cutaneous lymphoma and no metastases were detected on CT-scan.

Based on promising results in domestic carnivores,1–4 anti-tumoral treatment was attempted with masitiniba (50 mg PO q 48 h), a tyrosine kinase inhibitor labeled for the treatment of mastocytoma in dogs. Due to potential toxicity, and in the absence of pharmacokinetic studies in langurs, complete plasma chemistry was performed every two weeks.

One month later, general condition and bloodwork were still normal. In the absence of improvement of the lesions, the masitinib dose was increased to 50 mg PO SID, in association with antibiotics and steroids. However, effect on lesions was minimal, general condition worsened, and the animal died 4 months after onset of masitinib treatment. Pathology confirmed epitheliotropic CD3+ cutaneous lymphoma, with extensive cutaneous ulceration and marked infiltration of several lymph nodes.

To the authors’ knowledge, this is the first report of cutaneous epitheliotropic T-cell lymphoma in a langur, and the first attempt of treatment with masitinib in a primate species. Despite poor response, masitinib treatment was well-tolerated. Survival after initial presentation was 9 months. Further reports are needed to assess masitinib efficacy with an earlier onset of treatment and/or higher doses.


a. Masivet 50 mg, AB Science, 75008 Paris, France


The authors would like to thank AB Science laboratory, especially Dr. Pascal Brun, for their help with this case, and provision of masitinib.

Literature Cited

1.  Holtermann N, Kiupel M, Kessler M, Teske E, Betz D, Hirschberger J. Masitinib monotherapy in canine epitheliotropic lymphoma: masitinib canine epitheliotropic lymphoma. Vet Comp Oncol. 2016;14:127–135.

2.  Sapierzyński R, Jankowska U, Jagielski D, Kliczkowska-Klarowicz K. Large granular lymphoma in six cats. Pol J Vet Sci. 2015;163–169.

3.  Sayag D, Pastor M. Utilisation hors AMM des inhibiteurs des tyrosine-kinases en cancérologie vétérinaire. Le Point Vétérinaire. 2014:349.

4.  Zandvliet M, Teske E, Chapuis T, Fink-Gremmels J, Schrickx JA. Masitinib reverses doxorubicin resistance in canine lymphoid cells by inhibiting the function of P-glycoprotein. J Vet Pharmacol Ther. 2013;36(6):583–587.


Speaker Information
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Antoine Leclerc, DVM, DECZM (ZHM)
ZooParc de Beauval & Beauval Nature
Saint-Aignan, France

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