The Comparison of the Effect of Xylazine / Tiletamine / Zolazepam and Isoflurane Inductions on GFR in Cats
World Small Animal Veterinary Association World Congress Proceedings, 2007
SumitDurongphongtorn1; Suwicha Chuthatep2; Vichuda Kwanchai2; Sirinthorn Yibchock-Anan2; Tawatchai Chaiwatanarat3
1Chulalongkorn University, Bangkok, Thailand; 2Faculty of Veterinary Science, Chulalongkorn University; 3Faculty of Medicine, Chulalongkorn University


An induction is the crucial stage of general anesthesia which causes cardiovascular changes. Renal perfusion is also influenced by cardiovascular changes such as bradycardia or hypotension. Renal failure may occur after anesthesia especially in patient with marked decrease renal perfusion. Glomerular filtration rate (GFR) is the most sensitive renal perfusion parameter which can be effectively determined by scintigraphic technique.


To determine and compare the effect of the two different anesthetic methods on the glomerular filtration rate in anesthetized cat by using renal scintigraphy.


10 adult healthy cats were studied by using crossover design with 1 month interval. Cats were divided into 2 groups of Xylazine/ Tiletamine/ Zolazepam and Isoflurane inductions. Renal scintigraphy was performed for determine GFR by using 99mTc-DTPA (Diethylenetriaminepentaacetic acid) as a radiopharmaceutical. The GFR from both inductions were statistical analyzed by means of a Paired t-test which significance was set at p < 0.05.


All cats were modest induced and recovered from both inductions. The mean GFR ± standard deviation of Xylazine/ Tiletamine/ Zolazepam and Isoflurane groups were 1.16 ± 0.31 and 0.89 ± 0.36 respectively. There was no significant difference of the GFR between two different induction methods.


Although several factors influence GFR, both injection and inhalation anesthesia show the same GFR changes in early stage of anesthesia in healthy cat.

Speaker Information
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Sumit Durongphongtorn
Chulalongkorn University
Bangkok, Thailand

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