Effects of Several Inspired Oxygen Fractions on the Respiratory Dynamics in Spontaneously Breathing Dogs Undergoing Continuous Infusion of Propofol
World Small Animal Veterinary Association World Congress Proceedings, 2007
Patricia Cristina Ferro Lopes1, MS; Newton Nunes1; Roberta Carareto1, MS; Celina Tie Duque Nishimori1; Danielli Parrilha de Paula1; Marlos Gonçalvez Sousa1, MS; Paulo Sérgio Patto dos Santos2; Roberto Thiesen1, MS
1Department of Clinics and Veterinary Surgery, Faculdade de Ciências Agrárias e Veterinárias, UNESP, Jaboticaba Campus; 2Department of Clinics, Surgery and Animal Reproduction, Faculdade de Medicina Veterinária de Araçatuba, UNESP, Araçatuba Campus

The aim of this work was to evaluate the effects of several inspired oxygen fractions (FiO2) on the respiratory dynamics in spontaneously breathing dogs submitted to continuous infusion of propofol. Eight adult mongrel dogs were used. Each animal underwent five anesthesias. In each procedure the patient was allowed to breathe a different FiO2, thereby resulting in five groups, namely: G100 (FiO2 = 1), G80 (FiO2 = 0.8), G60 (FiO2 =0.6), G40 (FiO2 = 0.4), and G20 (FiO2 = 0.21). To induce anesthesia, propofol was given until the animals allowed orotracheal intubation, followed by immediate continuous infusion of drug (0.7 mg/kg/min). The initial measurement (M0) of breathing frequency (f), end-tidal carbon dioxide partial pressure (ETCO2), arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2), hemoglobin saturation (SaO2), base deficit (BD), bicarbonate (HCO3-) and pH was recorded thirty minutes after the infusion of propofol has begun. Additional recordings were performed at 15-minute intervals for 60 minutes (M15, M30, M45 and M60). Numeric data were submitted to Analysis of Variance followed by Tukey Test (p<0.05). We recorded significant lower values of SaO2 at G20, whereas PaO2 varied according to the changes in oxygen. Regarding PaCO2 the mean of G100 was greater than G20 at M30. However, spontaneously breathing dogs anesthetized with propofol should not be provided with 100%, 80%, and 21% oxygen due to the significant impairment of respiratory system.

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Patricia Cristina Ferro Lopes
Departament of Clinics and Veterinary Surgery, Faculdade de Ciências Agrárias e Veterinárias, UNESP
SP, Brazil

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