Clinical Efficacy of Cephalexin Tablets in the Treatment of Cutaneous Wounds and Abscesses in Cats
World Small Animal Veterinary Association World Congress Proceedings, 2006
L. Maynard1, V. Skowronski1, A. Sanquer1, C. Medaille2
1VIRBAC, Carros, France; 2VEBIOTEL, Aristide Briand, Arcueil, France

A multicentre, controlled, randomised field trial was performed in France to evaluate the efficacy of Cephalexin administered per os at a dosage of 15 mg/kg twice daily for 5 days in the treatment of cutaneous and subcutaneous infections in the cat. A total of 114 cats were included in the study. Fifty-seven cats were treated with Cephalexin-based tablets (Rilexine®, Virbac) at the recommended dosage; 56 cats were treated with Marbofloxacin-based tablets (Marbocyl® P, Vetoquinol) at the recommended dosage of 2 mg/kg body weight SID. Both treatments were administered for 5 days. Cats were clinically observed on 3 days: D0, D5 and D0 (5 days after end of treatment). On D0, a cutaneous swab was taken from each enrolled animal for bacteriological analysis. Efficacy of the products was assessed by the percent clinical recovery (total disappearance of local signs: suppuration, oedema, pain, redness/heat) on D10 and percent relapses. On D0, there was no significant difference between groups for demographic characteristics, clinical signs or for bacteriological results. Approximately 68.1% of enrolled cats presented with an abscess; 21.2% presented with an infected wound; 10.6% presented with both a wound and abscess. Pasteurella multocida represented 42.9% of the isolated pathogens. Gram-negative bacteria represented 67.2% of the total isolates and Gram-positive bacteria (Staphylococcus spp, Streptococcus spp) represented 32.8%. Out of the 113 cats treated on D0, 78 (69.0%) no longer had local clinical signs after treatment 41 (71.9%) in the Cephalexin-treated group and 37 (66.1%) in the Marbofloxacin-treated group (p=0.5007)). Only one cat from the Cephalexin-treated group relapsed. (p=1.0000). Based on these results, Cephalexin administered orally at a dosage of 15 mg/kg twice daily for 5 days is at least as effective as Marbofloxacin administered at the recommended dosage of 2 mg/kg once daily for 5 days in the treatment of cutaneous wounds and abscesses in cats.

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L. Maynard
Carros, France

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