HISTORY

Ibuprofen is a non-steroidal anti-inflammatory (NSAID) used in veterinary medicine as carprofen, ketoprofen, acetaminophen and tolfenamic acid. Ibuprofen must not be used in dogs because there isn't a recommended therapeutic dosage for this product without toxic effects, although some authors say this one is 10mg/kg/day. The made studies indicate that ibuprofen used to higher dose and during too much time, causes a lot of problems of chronic toxicity (clinical patterns with the followings symptoms: vomits, anorexia, depression of the CNS and Ibuprofen is a non-steroidal anti-inflammatory (NSAID) used in veterinary medicine as carprofen, ketoprofen, acetaminophen and tolfenamic acid. Ibuprofen must not be used in dogs because there isn't a recommended therapeutic dosage for this product without toxic effects, although some authors say this one is 10mg/kg/day. The made studies indicate that ibuprofen used to higher dose and during too much time, causes a lot of problems of chronic toxicity (clinical patterns with the followings symptoms: vomits, anorexia, depression of the CNS and circulatory manifestations that correspond with the presence of gastric and intestinal sores in association to renal problems). The objective of the present work is the description of a case of acute toxicity for ingestion of ibuprofen utilized such as analgesic to elevated dose, which produced a death of the animal for hypovolemic shock.

We have studied a brie sheepdog, female, 11 years old and 30kg. We did a surgical minor intervention consistent in the exeresis of two small verruca and it was slept with xilacine and we use mepivacaine like local anesthesia too. The animal was recovered of the sedation by means on the administration on atipemazol and it was sent to home with the opportune antibiotic treatment and the local cures.

DISCUSSION

In the following 12 hours the animal is pain and her owner, without to ask his vet, decides to administrate ibuprofen (Neobufren? 600 (tm) capsules). The dose was 1200 mg twice a day. The next day, the animal suffered debility, prostration, anorexia, benign hypothermia, pallid mucosas and abdominal ache together with hemorrhagic vomits and it died three hours later. Many gastric sores are observed in the necropsy and they were situated preferably in the zone of the pyloric antrum. There were big clots and an important imbibition in the whole intestine. Samples were taken in formaldehyde for the histopathologic study, confirming the microscopic lesions the depth of the gastric sores and the absence of erosions in the intestinal mucosa.

The acute intoxication for ingestion of elevated doses of ibuprofen, originates the death for hypovolemic shock in a few hours, therefore unlike it happens in human medicine. The application of this NSAID must be avoided because the security dose is not determined for use in dogs and overcoat the therapeutic dose is higher than the toxic dose.