Introduction
#1 canine anxiety disorder seen in behavior practices; Potential for great financial cost; Most common in mixed breed dogs from shelters
Fear
Emotional state in animals; the subjective state of fear is presumed to exist; exhibit specific behavior, e.g., avoidance, crying signals that are typically associated with these behaviors. Normal behavior can be adaptive. Small dog who was attacked by big dog. Determine normality or abnormality by context
Phobia
 Fear reactions that are persistent, consistent, not adaptive, dog that is afraid of the phone ringing
 Fear reactions that are persistent, consistent, not adaptive, dog that is afraid of the phone ringing 
Degrees of Phobia
 Intense: Hysteria, catatonia, panic
 Intense: Hysteria, catatonia, panic
 Mild: Anxiety
 Mild: Anxiety
What is Separation Anxiety?
 General symptoms:
 General symptoms:
 Inappropriate behaviors during owner absence
 Inappropriate behaviors during owner absence
 Often done within first 30 min.
 Often done within first 30 min.
 Fear of separation from owner
 Fear of separation from owner
 May see in younger and older dogs
 May see in younger and older dogs
 Change in schedule
 Change in schedule
Role of Attachment?
 Assumption: Dogs with separation anxiety are hyperattached to their owners
 Assumption: Dogs with separation anxiety are hyperattached to their owners
 Attachment: Emotional bond
 Attachment: Emotional bond
 Attachment Behaviors: Maintain spatial closeness
 Attachment Behaviors: Maintain spatial closeness
 Vocalizations, maintaining proximity to owners, trying to follow owner through doors/windows
 Vocalizations, maintaining proximity to owners, trying to follow owner through doors/windows
Dog Attachment Study
 Separation anxiety questionnaire
 Separation anxiety questionnaire
 Attachment test
 Attachment test
 30 min. home videotape
 30 min. home videotape
History-Taking
 Previous history?
 Previous history?
 What behaviors exhibited?
 What behaviors exhibited?
 When behaviors exhibited?
 When behaviors exhibited?
 When behaviors started?
 When behaviors started?
 Behaviors follow patterns?
 Behaviors follow patterns?
 What does dog do when:
 What does dog do when:
 Owner prepares to leave?
 Owner prepares to leave?
 Owner comes home?
 Owner comes home?
 While owner is away?
 While owner is away?
 What has been done to correct the problem?
 What has been done to correct the problem?
Symptoms
 Occurs during owner absence:
 Occurs during owner absence:
 Excessive vocalization
 Excessive vocalization
 Inappropriate elimination
 Inappropriate elimination
 Destruction
 Destruction
Symptoms
 Other Symptoms
 Other Symptoms
 Anorexia
 Anorexia
 GI upset
 GI upset
 Lack of activity ("depression")
 Lack of activity ("depression")
 Severe cases: Dogs will show symptoms while owner is in another room of house, or asleep
 Severe cases: Dogs will show symptoms while owner is in another room of house, or asleep
Symptoms
 Before owner leaves:
 Before owner leaves:
 Hide
 Hide
 Look anxious/"depressed"
 Look anxious/"depressed"
 Ears back
 Ears back
 Head lowered
 Head lowered
 Whine
 Whine
 Pant
 Pant
 Pace
 Pace
 Follow owner around
 Follow owner around
 Refuse to enter crate
 Refuse to enter crate
 Prevent owner from leaving
 Prevent owner from leaving
Symptoms
 When owner returns home
 When owner returns home
 Excessive greeting behavior
 Excessive greeting behavior
 Long time to calm down
 Long time to calm down
 "Velcro dogs"
 "Velcro dogs"
Behavioral Rule-Outs
 Excessive Vocalization
 Excessive Vocalization
 External stimuli
 External stimuli
 Garbage truck
 Garbage truck
 Dog barking
 Dog barking
 Neurological disorder
 Neurological disorder
Behavioral Rule-Outs
 Inappropriate elimination
 Inappropriate elimination
 Medical problems
 Medical problems
 Incomplete housetraining
 Incomplete housetraining
 Loss of housetraining
 Loss of housetraining
 Urine marking
 Urine marking
 Management issues
 Management issues
 Acute fear response
 Acute fear response
 Arousal-related response
 Arousal-related response
Behavioral Rule-Outs
 Destructiveness
 Destructiveness
 Play
 Play
 Teething
 Teething
 External stimuli
 External stimuli
 Acute fear response
 Acute fear response
 No appropriate objects to chew
 No appropriate objects to chew
 Barrier frustration
 Barrier frustration
Degree of Separation Anxiety
 Separation anxiety is not all-or-nothing
 Separation anxiety is not all-or-nothing
 Continuum of fear
 Continuum of fear
 Some dogs may have "anxieties" while others may have stronger "phobias"
 Some dogs may have "anxieties" while others may have stronger "phobias"
Learning and Separation Anxiety
 Separation anxiety itself is based on fear
 Separation anxiety itself is based on fear
 Learning involved as well
 Learning involved as well
 Classical conditioning of emotional responses to pre-departure cues
 Classical conditioning of emotional responses to pre-departure cues 
 Keys, briefcase, security system, coat
 Keys, briefcase, security system, coat
 Classical conditioning of emotional responses during owner's return
 Classical conditioning of emotional responses during owner's return
Classical Conditioning: 
 Pre-Departure Cues
 Pre-Departure Cues
Misuse of Punishment
 Many owners punish their dogs after they arrive home
 Many owners punish their dogs after they arrive home
 Delayed punishment not effective
 Delayed punishment not effective
Diagnosis
 Clinical test to diagnose separation anxiety?
 Clinical test to diagnose separation anxiety?
 Leaving dog alone in room does not seem to be diagnostic
 Leaving dog alone in room does not seem to be diagnostic
 Degree of whining may be indicator of separation anxiety if severity of behaviors is considered
 Degree of whining may be indicator of separation anxiety if severity of behaviors is considered
Treatment: General Outline
 Environmental modification
 Environmental modification
 Behavior modification
 Behavior modification
 Extinction of pre-departure cues
 Extinction of pre-departure cues
 Graduated departures with safety cue
 Graduated departures with safety cue
 Pharmacological therapy
 Pharmacological therapy
Treatment: Environmental Modification
 Keep dog crated or confined if can be done safely
 Keep dog crated or confined if can be done safely
 Start with door open
 Start with door open
 Reward whenever inside
 Reward whenever inside
 Close door for gradually increasing amounts of time; reward when calm
 Close door for gradually increasing amounts of time; reward when calm
 Release from crate only when calm
 Release from crate only when calm
 Hide toys/treats inside
 Hide toys/treats inside
Treatment: Environmental Modification
 Restrict access to items being destroyed
 Restrict access to items being destroyed
 Rotate toys to maintain interest
 Rotate toys to maintain interest
 Interactive toys
 Interactive toys
Treatment: Behavior Modification
 During departures
 During departures
 Downplay event
 Downplay event
 During returns
 During returns
 Ignore dog until completely calm
 Ignore dog until completely calm
 Redirect into a "sit"
 Redirect into a "sit"
 Relaxation training
 Relaxation training
 Independence training
 Independence training
Treatment: Behavior Modification
 Extinction of pre-departure cues
 Extinction of pre-departure cues
Treatment: Behavior Modification
 Graduated Departures using Safety Cue
 Graduated Departures using Safety Cue
 Safety Cue: Signal that tells dog that owner will return soon
 Safety Cue: Signal that tells dog that owner will return soon
 Visual: flag, sign, blanket
 Visual: flag, sign, blanket
 Auditory: bell, whistle
 Auditory: bell, whistle
 Olfactory: potpourri spray
 Olfactory: potpourri spray
 Owner acts as though leaving for work
 Owner acts as though leaving for work
 Leave dog in place that owner would like dog to be able to stay when alone
 Leave dog in place that owner would like dog to be able to stay when alone
Graduated Departures
 Dog does not need to be completely calm when performing exercise
 Dog does not need to be completely calm when performing exercise
 Warning! If use safety cue during actual departure, will lose efficacy
 Warning! If use safety cue during actual departure, will lose efficacy
 Determine how long dog can stay alone without showing full-blown symptoms (e.g., 30 sec)
 Determine how long dog can stay alone without showing full-blown symptoms (e.g., 30 sec)
 Act as though going to work
 Act as though going to work
 Give safety signal and walk out for 30 sec
 Give safety signal and walk out for 30 sec
 Return, remove signal (if visual), and allow dog to calm fully
 Return, remove signal (if visual), and allow dog to calm fully
 Repeat at least 10 times
 Repeat at least 10 times
 Dog should be calm upon departure and return
 Dog should be calm upon departure and return
Treatment: Pharmacological
 Clomipramine HCl (ClomicalmTM)
 Clomipramine HCl (ClomicalmTM)
 Tricyclic antidepressant
 Tricyclic antidepressant
 FDA-approved for separation anxiety in dogs
 FDA-approved for separation anxiety in dogs
 Extra-label medications with anxiolytic effects
 Extra-label medications with anxiolytic effects
 e.g., Fluoxetine, Amitriptyline
 e.g., Fluoxetine, Amitriptyline
Get Another Dog?
 Another dog may solve problem
 Another dog may solve problem
 Since appears to be related to owner leaving, may not work
 Since appears to be related to owner leaving, may not work
Remind Owners: In The Meantime...
 What to do with dog until treatment starts working?
 What to do with dog until treatment starts working?
 Crating/confining (if safe)
 Crating/confining (if safe)
 Pet sitter
 Pet sitter
 Doggie day care
 Doggie day care
 Boarding
 Boarding
 Take to work
 Take to work
Prognosis
 Will depend on:
 Will depend on:
 Severity
 Severity
 Duration of problem
 Duration of problem
 Compliance of owners
 Compliance of owners
Case Report: NICKY
 Signalment
 Signalment
 5-year-old Fem German shepherd
 5-year-old Fem German shepherd 
 Family
 Family
 Mónica and Raúl
 Mónica and Raúl
 Complaints: panic when owners left house, destructive when uncrated
 Complaints: panic when owners left house, destructive when uncrated
 When crated: defecated/urinated, moves crate/ trying to escape, barked, hypersalivated, chewed paws, exhausted
 When crated: defecated/urinated, moves crate/ trying to escape, barked, hypersalivated, chewed paws, exhausted
 Previous history
 Previous history
 Obtained at 7 weeks from breeder
 Obtained at 7 weeks from breeder
 Onset of behaviors
 Onset of behaviors
 Around 6 months of age when female owner started new job
 Around 6 months of age when female owner started new job
 Previous treatments
 Previous treatments
 Medication
 Medication
 Acepromazine (discontinued)
 Acepromazine (discontinued)
 Crate training
 Crate training
 Diagnosis
 Diagnosis
 Separation anxiety
 Separation anxiety
 Treatment (Separation Anxiety)
 Treatment (Separation Anxiety)
 Independence training
 Independence training
 Extinguish reaction to pre-departure cues
 Extinguish reaction to pre-departure cues
 Gradual departures using safety cues
 Gradual departures using safety cues
 Alprazolam 1 tablet 0.25 mg before owner leaves and Clomipramine 1 tablet 25mg q 12h / 2 weeks
 Alprazolam 1 tablet 0.25 mg before owner leaves and Clomipramine 1 tablet 25mg q 12h / 2 weeks
 Follow-up
 Follow-up
 2 weeks: Departures with safety cue (potpourri spray)
 2 weeks: Departures with safety cue (potpourri spray)
 Recommendation: decrease Alprazolam dosage to ½ tablet when owner leaves continue with Clomipramine 2 tablets 25mg q 12h
 Recommendation: decrease Alprazolam dosage to ½ tablet when owner leaves continue with Clomipramine 2 tablets 25mg q 12h
 1 month: Owner had been out of town. Therapy program discontinued.
 1 month: Owner had been out of town. Therapy program discontinued.
 2 months: Graduated departures with safety cue, independence training Alprazolam- Clomipramine
 2 months: Graduated departures with safety cue, independence training Alprazolam- Clomipramine
 3 months: Decrease Alprazolam dose to every other day and continue with Clomipramine as is. Continue independence exercises
 3 months: Decrease Alprazolam dose to every other day and continue with Clomipramine as is. Continue independence exercises
 4 months: Suspend Alprazolam continue with Clomipramine
 4 months: Suspend Alprazolam continue with Clomipramine 
 4.5 months: Decrease Clomipramine to 25mg q 12 h and gradually taper Clomipramine treatment until suspended
 4.5 months: Decrease Clomipramine to 25mg q 12 h and gradually taper Clomipramine treatment until suspended
 Continue behavior modification treatment
 Continue behavior modification treatment 
 5 months: Owners were satisfied with treatment
 5 months: Owners were satisfied with treatment
Final messages
 Severe separation anxiety cases can be resolved
 Severe separation anxiety cases can be resolved
 May take a while
 May take a while
 Client complicity is essential
 Client complicity is essential
 Minor relapses are possible-don't be discouraged!
 Minor relapses are possible-don't be discouraged!