Plasma Renin Activity and Plasma Concentrations of Aldosterone, Cortisol, ACTH and A-MSH in Healthy Household Cats
World Small Animal Veterinary Association World Congress Proceedings, 2003
S. Javadi; L.I. Slingerland; M.G. van de Beek; P. Boer; W.H. Boer; A. Rijnberk; H.S. Kooistra
Dept. of Clin. Sciences of Companion Animals, Faculty of Veterinary Medicine
Utrecht, NL


In both systemic arterial hypertension and hypokalemic myopathy in cats a pathogenetic role of the renin-angiotensin-aldosterone system has been implicated. The aim of this study was to determine reference ranges for plasma aldosterone concentration (PAC), plasma renin activity (PRA) and the PAC to PRA ratio (ARR) in household cats. To investigate the possible influence of stress on these values, also the pituitary-adrenocortical axis was studied.

Materials & Methods

In order to obtain appropriate reference values, blood samples for the determination of the plasma concentrations of sodium, potassium, aldosterone, cortisol, adrenocorticotrophic hormone (ACTH), α-melanocyte stimulating hormone (α-MSH) and PRA were collected in 130 healthy household cats.


Median values and reference ranges for PAC (235; 110-540 pmol/l), PRA (200; 60-630 fmol/l/s), and ARR (1.3; 03.-3.8) were very similar to the reference values established in the same laboratory for humans in supine position. The plasma concentrations of ACTH, α-MSH, and cortisol did not correlate significantly with PAC.


It is concluded that despite the fact that blood sampling was performed in cats in non-standardized positions and was associated with a wide variation of stress responses, the references ranges are similar to the relatively narrow limits established for humans in standardized position.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

S. Javadi
Dept. of Clin. Sciences of Companion Animals, Faculty of Veterinary Medicine
Utrecht, NL

MAIN : Oral Presentations : Renin, Aldosterone, Cortisol, ACTH
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.


777 W. Covell Blvd., Davis, CA 95616


  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357