Hepatorenal Syndrome and Efficiency of Aldosterone Receptor Blockade in Experimentally Bile Duct Ligated Dogs
In this study, the effects of an aldosterone antagonist on the hepatorenal system and systemic hemodynamics in common bile duct ligated (CBL) dogs were investigated.
Materials & Methods
CBL dogs (n=14) and the sham operated but no ligated dogs (n=14) were again divided into two groups for giving a derivative of spironolactone (ALDOCTAN® tablet), at 1.5 mg/kg daily for six weeks. Hepatorenal changes and systemic effects of medicine were observed with necessary checkings and by comparing of control and test groups in the decompensation period which occurred on 4-6 weeks of hepatic cirrhosis.
It was determined that, after the operation the serum levels of ALT, AST, T.Biluribin, D.Biluribin, ALP and GGT increased statistically significantly (p<0.001-0.05) the serum levels of T.Protein and albumin decreased in all dogs. It was observed that the serum levels of aldosterone, Na and K were within the normal limits and the systemic hemodynamics and the heart rate were the same in all groups. At the other hand, glomerular filtration rate which evaluated with serum Cystatin C level, was decreased specially non-aldactonized cirrhotic dogs.
It was determined that the aldosterone receptor antagonists prevent decrease of the glomerular filtration rate even in early stage so that it can be useful to prevent the edema and ascites in cirrhotic dogs.