The Impact of Diet Fat on Cholesterol, Triglyceride and 3-OH-Butyrate Concentrations in Blood Samples of Dogs
World Small Animal Veterinary Association Congress Proceedings, 2017
A. Hielm-Björkman
Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland


Research show that a high-fat (HF) diet, compared to a high-carbohydrate (HC) diet, decreases cholesterol and triglycerides in man.


To see if dogs on a HF-LC (high fat-low carb) diet change from a glucose metabolism towards a keto-body metabolism, we analysed 3-hydroxybutyrate, cholesterol and triglycerides from serum of dogs on HF-LC and LF­ HC (low fat-high carb) diets.


A total of 44 client-owned dogs were included in the analyses. Of these 26 dogs were fed a 100% raw HF-LC diet (50/0% in dry matter) and 18 dogs a 100% kibble LF-HC diet (17/48% in dry matter) for a mean of 129 days. All dogs were Staffordshire bull terriers. Triglycerides and 3-hydroxybutyrate were analysed from Li-hep plasma and cholesterol from serum. Statistical analyses were performed using the Mann-Whitney U test.


There was no difference of concentrations of any of the measured values between the diet groups at baseline. At the end of the diet intervention cholesterol (p<0.001) and triglycerides (p=0.011) were significantly lower whereas 3-hydroxybutyrate (p=0.021) was significantly higher when the dogs had been on a raw HF-LC diet, compared to on the LF-HC diet. Indicating better liver function, also ALAT (p=0.015) and AFOS (p<0.001) were significantly lower after the HF-LC diet.


This study shows significant effect of the diet on fat metabolism parameters in dogs: eating a high fat diet changes the energy metabolism from producing and using glucose to producing and using ketone bodies. Type of cholesterols should now be analyzed in dogs.


Speaker Information
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A. Hielm-Björkman
Department of Equine and Small Animal Medicine
Faculty of Veterinary Medicine
University of Helsinki
Helsinki, Finland

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