Effects of Spirulina platensis Supplementation on Serum Insulin and Adiponectin Levels in Rats Fed with Hydrogenated Vegetable Oil and/or Cholesterol
World Small Animal Veterinary Association World Congress Proceedings, 2015
A. Altiner1; T. Bilal2; O. Keser2
1Department of Biochemistry, Faculty of Veterinary Medicine, Istanbul University, Istanbul, Turkey; 2Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Istanbul University, Istanbul, Turkey


Antiobesity foods and food ingredients are effective in reducing the accumulation of fat in the body and can prevent diseases associated with lifestyle. One of them is Spirulina platensis (Spirulina), a blue-green cyanobacterium.


The aim of the study was to investigate whether Spirulina has the improver effects on serum insulin and adiponectin levels in rats fed with hydrogenated vegetable oil (HVO) and/or cholesterol.


Sixty-four male mature rats were separated into 8 equal groups. The control group was fed with a standard semipurified diet. Supplementations of other groups fed with same semipurified diet were as follows: Trial 1, 43% HVO; Trial 2, 10% cholesterol; Trial 3, 43% HVO + 10% cholesterol; Trial 4, 3% Spirulina; Trial 5, 43% HVO + 3% Spirulina; Trial 6, 10% cholesterol + 3% Spirulina; and Trial 7, 43% HVO + 10% cholesterol + 3% Spirulina. Blood was taken from all rats on the 30th and 60th days.


On the 60th day, serum insulin was significantly lower in cholesterol, Spirulina, cholesterol + Spirulina and oil + cholesterol + Spirulina groups than in oil and oil + Spirulina groups. On the 60th day, serum adiponectin was significantly lower in cholesterol, Spirulina and cholesterol + Spirulina groups than in control and oil + cholesterol groups.


The feeding with HVO and/or cholesterol were ineffective on serum insulin. Spirulina supplementation was ineffective on the feeding with HVO or cholesterol for serum insulin. The feeding with cholesterol and/or Spirulina significantly lowered the serum adiponectin levels. Serum adiponectin did not change in all groups added HVO.


Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

A. Altiner
Department of Biochemistry
Faculty of Veterinary Medicine
Istanbul University
Istanbul, Turkey

MAIN : Diagnostic Imaging : Spirulina platensis on Insulin & Adiponectin Levels
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.


777 W. Covell Blvd., Davis, CA 95616



  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357