Immunohistochemical Expression of Involucrin in a Multirecurrent Canine Cutaneous Squamous Cell Carcinoma (SCC)
Introduction and Objective
Cutaneous squamous cell carcinoma (SCC) is a malignancy tumor both in human and various species. Many researches have applied for histopathology grading and biomolecular markers for prognostic value and treatment. The objectives of this study are to demonstrate the immunohistochemical (IHC) expression of involucrin (INV), a cornified envelope protein and histopathological grading in a multirecurrence canine cutaneous SCC.
Squamous cell carcinomas were collected from a 7 year, white color, male dog with 4 times surgical treatment of 2–3 cm in diameter at inguinal mass, during 8 months observation. The mass was presented after chronic licking (> 8 months) at the healing castrated area. Subsequently, clinical signs and treatments were shown in Table 1. The biopsies of the 2nd and 4th surgical excisions were collected for histopathological classified (Goldschmidt & Hendrick 2002) and the INV-IHC staining was performed as previous described (Sailasuta et al. 2013).
Results and Conclusion
The results of the 2nd and 4th times of recurrence cutaneous SCC, the 4th time revealed progressive undifferentiated SCC and decreased on INV-IHC expression in comparison to the 2nd time. In addition, that relates to the short period of recurrence. However, no remarkable evidence of metastasis was recognized. These results implied the possibility of INV in the role of candidate marker for cutaneous SCC prognosis and therapeutic guideline in the clinical case.
VIN editor: Table 1 was not provided at time of publication.
1. Goldschmidt MH, Hendrick MJ. Tumors of the skin and soft tissues. In: DJ Mueten, ed. Tumors in Domestic Animals. Ames, IA: Iowa State Press; 2002: 45–117.
2. Sailasuta A, Suriyaphol G, Theerawatanasirikul S, Assawawongkasem N. In: Proceedings from the 38th International Conference on Veterinary Sciences; January 16–18, 2013: 10; Thailand.