Analgesic Effects of Firocoxib in Cats after Ovariohysterectomy
World Small Animal Veterinary Association World Congress Proceedings, 2015
P. Phuwapattanachart; N. Thengchaisri
Department of Companion Animal Clinical Sciences, Kasetsart University, Bangkok, Thailand

Introduction

Various analgesic agents including non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to be effective for pain control in cats. Firocoxib, a NSAIDs classified as a selective COX-2 inhibitor, has been successfully used in dogs; however, the efficacy of firocoxib in cats remains elusive.

Objectives

The purpose of a present study was to study the post-operative analgesic effects of firocoxib in cats undergoing ovariohysterectomy.

Methods

Twenty-four cats were divided into 3 groups including a control (no medicine), a firocoxib-1 (1 mg/kg/day) and a firocoxib-3 (3 mg/kg/day). The NSAIDs were given at 1 h before induction with propofol 4–6 mg/kg IV, followed by anesthesia maintenance with isoflurane. Colorado pain scores were recorded in blinded fashion before induction (base line) and 2, 5, 8, 24, 30, and 48 hours following the recovery.

Results

The average baseline of Colorado pain scores from control, firocoxib-1 and firocoxib-3 groups were not different (0.4 ± 0.2, 0.3 ± 0.1, and 0.5 ± 0.2, respectively; p-value > 0.05). The average Colorado pain scores recordings to 48 hours post-operation from firocoxib-3 groups (0.4 ± 0.1) were significantly lower than that of control group (0.7 ± 0.2; p-value = 0.004). However, no significant difference was found between the average pain scores of firocoxib-1 (0.5 ± 0.2) and control groups (p-value = 0.12). One cat from firocoxib-3 treated group vomited one time at 48 hours post-operation.

Conclusions

The present study suggests that firocoxib-3 is helpful for post-operative pain control in cats; however, gastrointestinal irritation due to the use of NSAIDs may occur.

  

Speaker Information
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P. Phuwapattanachart
Department of Companion Animal Clinical Sciences
Kasetsart University
Bangkok, Thailand


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