Psychological Drug Side Effects in Dogs
World Small Animal Veterinary Association World Congress Proceedings, 2015
S.J. Aldavood1; H. Masarrat2; A. Massarat3; F. Ghanbari4; A. Alyari5
1Internal Medicine, University of Tehran, Tehran, Iran; 2Environmental Health, Takhte Jamshid Clinic, Tehran, Iran; 3Microbiology, Azad University, Tehran, Iran; 4Behavior, Azad University, Tehran, Iran; 5Internal Medicine, University of Tehran, Tehran, Iran

Introduction

Evaluation of the side effects of ecstasy on the nervous system, blood cells and blood biochemical factors and comparison of the dose-dependent effects of the drug on the clinical symptoms and survival of the animal. Addiction by two different doses is the main cause for this study. This research was approved by the SPCA Ethics Committee.

Objectives

The project applied six adult male dogs with the same feed and maintenance. The dogs were divided into two groups, namely group 1 and group 2. Blood samples were taken to evaluate normal blood values before the injection.

Methods

Then, group 1 was injected with one dose and group 2 with double doses of ecstasy supplied by Isfahan Medical University. Dog clinical and nervous symptoms were recorded on video tape before and after each injection. Blood samples were taken after two hours and sent for laboratory tests.

Results

Data were analyzed using T-test. In clinical trial, the animals showed abnormal symptoms. Hematology of the dog's blood indicated a general increase in blood cells, especially for lymphocytes. Blood glucose, BUN, bilirubin and liver enzymes increased while albumin decreased.

Conclusions

These data revealed the stress effect of ecstasy on dog's vital organs, such as liver and kidneys, which had previously been supported by a mice study. However, we concluded that ecstasy had significant side effects on dog organ function, but no addiction was seen.

  

Speaker Information
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S.J. Aldavood
Internal Medicine
University of Tehran
Tehran, Iran


MAIN : Clinical Pharmacology & Toxicology : Psychological Drug Side Effects in Dogs
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