The Effect of Symptomatic Improvements Observed by Switching to Alacepril from Other ACE-Inhibitors in Dogs with Mitral Regurgitation
World Small Animal Veterinary Association World Congress Proceedings, 2015
K. Shimada; R. Tanaka; L. Hamabe
Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fucyu, Japan

Alacepril is an ACE-inhibitor (ACE-I) which has unique properties including excellent vascular wall penetration, peripheral sympathetic nerve suppressive effect, and negative chronotropic effect. It is also suggested to have a superior cough suppressive effect in comparison to other ACE-Is. The purpose of this study was to evaluate whether switching to alacepril from other ACE-Is will alleviate the clinical symptoms of congestive heart failure (CHF) caused by mitral regurgitation (MR) including coughing which could not be adequately controlled by the previously used ACE-I.

Clinical trial involving 73 client-owned dogs with MR that had been treated with ACE-Is other than alacepril was conducted for over a period of one month. Clinical examination was performed before and 4 weeks after the switch to alacepril. General clinical conditions, such as vigor, activeness, appetite and frequency of cough, were scored. Heart rate and body weight were also recorded.

Overall clinical condition suggested an overall symptomatic improvement. Individually, vigor, activeness and frequency of cough showed the greatest improvement with p < 0.0001, whereas appetite showed moderate improvement with p = 0.0055. Body weight and heart rate resulted in significant reduction with p = 0.0073 and p < 0.0001, respectively.

Under the condition of this study, switching to alacepril from other ACE-Is has shown to reduce the heart rate, and also to improve the symptoms of CHF, especially the frequency of cough. Alacepril may be useful in clinical cases of MR with cough that is difficult to control.

  

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

K. Shimada
Faculty of Agriculture
Tokyo University of Agriculture and Technology
Fucyu, Japan


MAIN : Cardiorespiratory Medicine & Surgery : Alacepril vs. Other ACE-Inhibitors in Mitral Regurgitation
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.

CONTACT US

777 W. Covell Blvd., Davis, CA 95616

vingram@vin.com

PHONE

  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357
SAID=27