The Role of Electrolytes and Proteins in the Metabolic Acid-Base Changes of Canine Parvoviral Enteritis
World Small Animal Veterinary Association World Congress Proceedings, 2014
R. Burchell; A. Leisewitz; J.P. Schoeman
Faculty Veterinary Science, University of Pretoria, Pretoria, South Africa

The acid-base disturbances in canine parvoviral (CPV) enteritis are not well described. Three previous studies utilizing the Henderson-Hasselbalch model have produced conflicting results, and no CPV acid-base studies to date, have utilized the strong ion model (SIM). The purpose of this study was to assess acid-base changes in puppies suffering from CPV enteritis using a modified SIM approach. The hypothesis of this study was that severe acid-base disturbances would be present and that the SIM would provide patho-mechanistic insights that have not been fully appreciated by the Henderson-Hasselbalch model. The study retrospectively analysed data obtained from 42 puppies with confirmed CPV enteritis and 10 healthy controls. The CPV enteritis group had been allocated a clinical score to allow classification of the data according to clinical disease severity. The effects of changes in free water, chloride, L-lactate, albumin, and phosphate were calculated using the base excess algorithm. According to the SIM, 20/42 patients in the CPV group had a metabolic acidosis, 10/42 had a metabolic alkalosis and in 12/42 patients the overall effect was neutralizing. The most important contributor to the metabolic acid-base changes according to SIM was chloride (p < 0.001). In addition, significant differences where seen in the chloride effect according to disease severity where severely affected puppies tended to have a hypochloraemic alkalosis, whereas mildly affected puppies had a hyperchloraemic acidosis (p = 0.007). In conclusion, the acid-base disturbances in CPV are multifactorial and complex and the SIM provides more information regarding the origin of these changes.

  

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

R. Burchell
Faculty Veterinary Science
University of Pretoria
Pretoria, South Africa


MAIN : Oral Abstracts : Acid-Base Changes & Parvo
Powered By VIN

CONTACT US

777 W. Covell Blvd., Davis, CA 95616

mailto:vingram@vin.com

PHONE

  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357
SAID=27