Translational Research in Osteosarcoma: From Kids to Dogs and Back Again
World Small Animal Veterinary Association World Congress Proceedings, 2011
Stephen J. Withrow1, DVM; Ross M. Wilkins2, MD
1Associate Director of the Animal Cancer Center, Stuart Chair in Oncology, University Distinguished Professor, Chief Scientific Officer, NeoTREX® and Cancer Supercluster, Colorado State University, Fort Collins, CO, USA; 2The Denver Clinic for Extremities at Risk at Presbyterian St. Luke's Medical Center, Affiliate Faculty Colorado State University, Medical Director of AlloSource, Denver, CO, USA


Osteosarcoma in companion animals is almost identical to the same disease in people. Research in basic cancer biology and treatment is readily translational across species lines. Examples of this cross talk are presented in this paper based on the parallel careers of two musculoskeletal oncology surgeons (one DVM and one MD). Dogs provide a relevant model that is 10 times more prevalent than the corresponding human condition. Advantages to the dog model include spontaneous development, large size, intact immune system, shared genetic aberrations, response to traditional chemotherapies and owner compliance with clinical trials for their pets.

Speaker Information
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Ross M. Wilkins, MD
The Denver Clinic for Extremities at Risk
Presbyterian St. Luke's Medical Center
Denver, CO, USA

Stephen J. Withrow, DVM
Colorado State University
Fort Collins, CO, USA

MAIN : Award Lecture : Osteosarcoma Translational Research
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