Available Genetic Tests for Breed Specific Canine and Feline Genetic Disorders
Tufts' Canine and Feline Breeding and Genetics Conference, 2009
Jerold S. Bell, DVM
Tufts Cummings School of Veterinary Medicine

Disorder

Breeds

Type of Test

Test Facility

AB Blood Groups

Cats

Direct

UC-Davis VGL

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Boxer

Direct

Washington State U-Meurs Lab

Benign Familial Juvenile Epilepsy

Lagotto Romagnola

Direct

Canigen

Canine Leukocyte Adhesion Deficiency (CLAD)

Irish Red & White Setter
Irish Setter

Direct

Optigen
Animal Health Trust

Cardiomyopathy, Juvenile

Portuguese Water Dog

Linkage

PennGen

Cataract, Juvenile (Early Onset Hereditary Cataract-EHD)

Boston Terrier
French Bulldog
Staffordshire Bull Terrier

Direct

Animal Health Trust

Cataract

Australian Shepherd

Direct-Susceptibility Gene

Animal Health Trust

Cerebellar Ataxia

Spinone Italiano

Linkage

Animal Health Trust

Cerebellar Ataxia (NCL-A)

American Staffordshire Terrier

Direct

ANTAGENE
Optigen

Ceroid lipofuscinosis

Border Collie

Direct

Animal Health Trust
Optigen

Ceroid lipofuscinosis

American Bulldog
Dachshund
English Setter

Direct

OFA (Am. Bulldogs)
U Missouri

Coat Color and Nose Color Variation

Afghan Hound
Australian Shepherd
Belgian Shepherd
Border Collie
Briard
Brittany
Cardigan Welsh Corgi
Chinese Shar Pei
Collie (Rough, Smooth)
Cocker Spaniel
Curly-Coated Retriever
Dachshund
Dalmatian
Doberman Pinscher
English Cocker Spaniel
English Setter
English Springer Spaniel
Field Spaniel
Flat-coated Retriever
French Bulldog
German Shepherd
German Longhaired Pointer
German Shorthaired Pointer
German Wirehaired Pointer
Great Dane
Greyhound
Groenendael
Japanese Chin
Labrador Retriever
Laekenois
Large Munsterlander
Lowchen
Malinois
Miniature Schnauzer
Newfoundland
Pointer
Pomeranian
Poodle
Portuguese Water Dog
Pudelpointer
Pug
Shetland Sheepdog
Staffordshire Bull Terrier
Tervuren
Whippet
Wirehaired Pointing Griffon

Direct

HealthGene

Coat Color Gene Variations

Most Dog Breeds-see VetGen website

Direct

VetGen

Coat Color Genes - Cats

Most Cats

Direct

UC-Davis VGL

Coat Length (FGF5)

Border Collie
German Shepherd
Pembroke Welsh Corgi
Weimaraner

Direct

Animal Health Trust

Cobalamin Malabsorption (Methylmalonic Aciduria)

Australian Shepherd
Giant Schnauzer

Direct

PennGen

Cobalamin Malabsorption
(Methylmalonic Aciduria)

Basset Hound
Beagle
Border Collie
DSH
Komondor
Shar Pei

Phenotypic

PennGen

Collie Eye Anomaly
(Choroidal Hypoplasia)

Australian Shepherd
Border Collie
Lancashire Heeler
Nova Scotia Duck Tolling Retriever
Rough Coated Collie
Shetland Sheepdog
Smooth Coated Collie
Whippet. Longhair

Direct

Optigen

Cone (Retinal) Degeneration

German Shorthaired Pointer

Direct

Optigen

Congenital Hypothyroidism with Goiter (CHG)

Rat Terrier
Toy Fox Terrier

Direct

Michigan State University-Fyfe Lab.
PennGen

Congenital Macrothrombocytopenia

Cavalier King Charles Spaniel

Direct

Auburn Univ.-Boudreaux Lab

Congenital Stationary Night Blindness (RPE65-CSNB)

Briard

Direct

Optigen
Animal Health Trust

Copper Toxicosis

Bedlington Terrier

Direct

VetGen
Animal Health Trust

Cyclic Neutropenia (Grey Collie Syndrome)

Smooth Coated Collie
Rough Coated Collie

Direct

HealthGene

Cystinuria

Newfoundland
Labrador Retriever

Direct

Optigen (Newf only)
PennGen
VetGen (Newf only)

Degenerative Myelopathy (DM)

Boxer
Cardigan Welsh Corgi
Chesapeake Bay Retriever
German Shepherd Dog
Mixed-breed/Other breeds
Pembroke Welsh Corgis
Poodle, Standard
Rhodesian Ridgeback

Direct- Susceptibility Gene

OFA

Exercise Induced Collapse (EIC, Dynamin 1 Mutation)

Labrador Retriever

Direct

U Minn VDL

Factor VII Deficiency

Alaskan Klee Kai
Beagle
Scottish Deerhound

Direct

PennGen

Factor IX Deficiency
(Hemophilia B)

Airedale Terrier
Bull Terrier
German Wirehaired Pointer
Labrador Retriever
Lhasa Apso

Direct

Cornell Univ. Comparative Coag. Lab (GWP)
HealthGene (Others)

Factor XI Deficiency

Kerry Blue Terrier

Direct

PennGen

Fanconi Syndrome

Basenji

Linkage

OFA

Fanconi Syndrome

Basenji
Norwegian Elkhound

Phenotypic

PennGen

Fucosidosis

English Springer Spaniel

Direct

PennGen
Animal Health Trust

Glanzmann's Thrombasthenia (Type I)

Great Pyrenees
Otterhound

Direct

Auburn Univ.-Boudreaux Lab.

Globoid Cell Leukodystrophy

Cairn Terrier
West Highland White Terrier

Direct

Jefferson Medical Coll.

Glycogenosis (GSD) Type IIIa

Curly Coated Retriever

Direct

Michigan State University-Fyfe Lab.

Glycogenosis (GSD) Type IV

Norwegian Forest Cat

Direct

PennGen

GM1-Gangliosidosis

Portuguese Water Dog

Direct

New York University Neurogenetics Lab

GM2-Gangliosidosis

Burmese

Direct

UC-Davis VGL

Hypersarcosinemia

Portuguese Water Dog

Phenotypic

PennGen

Hyperuricosuria (SLC2A9)

Bulldog
Black Russian Terrier
Dalmatian

Direct

UC-Davis VGL
Animal Health Trust

Hypertrophic Cardiomyopathy

Maine Coon Cat
Ragdoll

Direct

Washington State U-Meurs Lab
UC-Davis VGL

Ichthyosis

Norfolk Terrier

Direct

Texas A&M-Comp Derm Lab

Ivermectin Sensitivity
(MDR1)

Australian Shepherd
Collie
German Shepherd Dog
Old English Sheepdog
Shetland Sheepdog
Other breeds

Direct

Washington State U-Pharm Lab

L-2-HGA (L-2-hydroxyglutaric aciduria)

Staffordshire Bull Terrier

Direct

Animal Health Trust

Mannosidosis

DSH
Persian

Direct

PennGen

Merle Gene (SILV)

Australian Shepherds
Beauceron Sheepdog
Border Collie
Cardigan Welsh Corgi
Catahoula Leopard Dog
Chihuahua
Cocker Spaniel
Collie
Dachshund
Great Danes
Norwegian Hound
Pitt Bull
Pomeranian
Pyrenean Shepherd
Shetland Sheepdogs

Direct

(GenMark has been bought by Idexx, who will be offering again in the future)

Mitochondrial Myopathy

Cocker Spaniel
Old English Sheepdog

Phenotypic

PennGen

Mucolipidosis II (I-Cell Disease)

DSH

Direct

PennGen

Mucopolysaccharidosis (MPS)

DSH
German Shepherd Dog
Miniature Pinscher
Miniature Schnauzer
Schipperke
Siamese

Direct

PennGen

Mucopolysaccharidosis (MPS)

Cardigan Welsh Corgi
Pembroke Welsh Corgi
Plotthound
Rottweiler
Wirehaired Dachshund

Phenotypic

PennGen

Musladin-Lueke Syndrome

Beagle

Direct

UC-Davis VGL

Muscular Myopathy (Centronuclear myopathy)

Labrador Retriever

Direct

Alfort School of Veterinary Medicine, France
Animal Health Trust

Myotonia Congenita

Miniature Schnauzer

Direct

Optigen
PennGen

Narcolepsy

Dachshund
Doberman Pinscher
Labrador Retriever

Direct

Optigen

Neonatal Encephalopathy

Standard Poodle

Direct

OFA

Nephropathy (Hereditary N., Familial N.)

English Cocker Spaniels

Direct

Optigen

Oculoskeletal Dysplasia (OSD)/Retinal Dysplasia (RD)

Labrador Retriever
Samoyed

Direct

Optigen

Perianal Fistula/Anal Furunculosis

German Shepherd

Direct- Susceptibility Gene

HT Diagnostics

Phosphofructokinase Deficiency (PFK)

American Cocker Spaniel
English Springer Spaniel
Whippet (VetGen only)

Direct

Optigen
PennGen
VetGen
Animal Health Trust (ESS)

Polycystic Kidney Disease (PKD)

American Shorthair
Himalayan
Persian
Scottish Fold

Direct

UC-Davis-VGL
Animal Health Trust

Primary Hyperoxaluria

Tibetan Spaniel

Phenotypic

PenGen

Primary Hyperparathyroidism

Keeshond

Linkage

Cornell-Goldstein Lab

Progressive Retinal Atrophy (cord1)

Dachshund, Miniature Longhaired & Smooth haired
English Springer Spaniel

Direct- Susceptibility Gene

Animal Health Trust
U-Missouri

Progressive Retinal Atrophy - Dominant

Bullmastiff
(English) Mastiff

Direct

Optigen

Progressive Retinal Atrophy (prcd)

American Cocker Spaniel
American Eskimo Dog
Australian Cattle Dog
Australian Shepherd
Chesapeake Bay Retriever
Chinese Crested
Cockapoo
English Cocker Spaniel
Entelbucher Mountain Dog
Finnish Lapphund
Golden Retriever
Kuvasz
Labradoodle
Labrador Retriever
Lapponian Herder
Nova Scotia Duck Trolling Retriever
Poodle; Miniature & Toy
Portuguese Water Dog
Spanish Water Dog
Stumpy Tail Cattle Dog
Swedish Lapphund

Direct

Optigen

Progressive Retinal Atrophy (rcd1)

Irish Red & White Setter
Irish Setter

Direct

Optigen
Animal Health Trust
VetGen (Irish Setter)

Progressive Retinal Atrophy (rcd1a)

Sloughi

Direct

Optigen
Animal Health Trust

Progressive Retinal Atrophy (rcd2)

Collie-Smooth and Rough

Direct

Optigen

Progressive Retinal Atrophy (rcd3)

Cardigan Welsh Corgi

Direct

Michigan State Univ. -Peterson-Jones Lab.
Optigen
VetGen

Progressive Retinal Atrophy (rdAc)

Abyssinian
Ocicat
Somali

Direct

UC-Davis VGL

Progressive Retinal Atrophy-Type A

Miniature Schnauzer

Direct

Optigen

Progressive Retinal Atrophy-X-Linked

Samoyed
Siberian Husky

Direct

Optigen

Pyruvate Dehydrogenase Phosphatase Deficiency
(PDH or PDP1)

Clumber Spaniel
Sussex Spaniel

Direct

U-Missouri
Animal Health Trust

Pyruvate Kinase Deficiency (PK)

Abyssinian
American Eskimo Dog
Basenji
Beagle
Cairn Terrier
Chihuahua
Dachshund
DSH
Somali
West Highland White Terrier

Direct

Optigen (Basenji)
PennGen (All)
VetGen (Basenji)
Animal Health Trust (Westies)
UC-Davis VGL (Cats)

Renal Dysplasia

Lhasa Apso
Shih Tzu
Soft Coated Wheaton Terrier

Linkage

VetGen

Retinal Dysplasia-Canine Multi-focal Retinopathy (CMR)

Bullmastiff
Coton de Tulear
Dogue de Bordeaux
Great Pyrenees
Mastiff (English & French)

Direct

Optigen

Severe Combined Immunodeficiency (SCID)

Bassett Hound
Cardigan Welsh Corgi
Pembroke Welsh Corgi

Direct

PennGen

Spinal Muscular Atrophy

Maine Coon Cat

Direct

Michigan State University-Fyfe Lab.

Thrombopathia

Bassett Hound
Landseer
Spitz

Direct

Auburn Univ.-Boudreaux Lab.

Trapped Neutrophil Syndrome (TNS)

Border Collie

Linkage

Univ. New South Wales

von Willebrand's Disease-Type I

Bernese Mountain Dog
Coton de Tulear
Doberman Pinscher
Drentsche Patrijshound
German Pinscher
Kerry Blue Terrier
Manchester Terrier
Papillion
Pembroke Welsh Corgi
Poodle

Direct

VetGen

von Willebrand's Disease-Type I

Irish Red and White Setters

Direct

Animal Health Trust

von Willebrand's Disease-Type II

Deutsch Drahthaar
German Shorthaired Pointer
German Wirehaired Pointer
Pointer

Direct

VetGen

von Willebrand's Disease-Type III

Kooikerhondje
Scottish Terrier
Shetland Sheepdog

Direct

VetGen

 Alfort School of Veterinary Medicine, France: http://www.labradorcnm.com/

 Animal Health Trust (England): http://www.aht.org.uk/genetics_tests.html

 ANTAGENE (France): http://www.antagene.com

 Auburn Univ.-Boudreaux Lab: http://www.vetmed.auburn.edu/home/departments/pathobiology/diagnostic-services/platelet-disorders (334-844-2692)

 Canigen (Univ. Helsinki, Finland): http://www.canigen.com/in_english/

 Cornell-Goldstein Lab: http://www.vet.cornell.edu/labs/goldstein/ (607-253-4480)

 Cornell Univ. Comparative Coagulation Lab: http://www.diaglab.vet.cornell.edu/coag/test/hemopwh.asp (607-275-0622)

 HealthGene: http://www.healthgene.com (877-371-1551)

 Jefferson Medical College: David.wenger@mail.tju.edu (215-955-1666)

 Michigan State University-Peterson-Jones Lab.: http://www.cardigancorgis.com/documents/Acrobat/membersPRASubmissionForm.pdf (517-353-3278)

 Michigan State University-Fyfe Lab.: http://mmg.msu.edu/92.html (517-355-6463x1559)

 New York University Neurogenetics Laboratory: http://www.pwdca.org/health/tests/GM1TestInstructions.html (212 263-2943)

 Optigen: http://www.optigen.com (607-257-0301)

 OFA: http://www.offa.org (800-442-0418)

 PennGen: http://www.vet.upenn.edu/penngen (215-898-8894)

 Texas A&M-Comp Derm Lab: Comparative Dermatology Lab at Texas A&M University (979-845-2561)

 UC-Davis VGL: http://www.vgl.ucdavis.edu/services/index.php (530-752-2211)

 U Minn Veterinary Diagnostic Laboratory: http://www.vdl.umn.edu/ourservices/canineneuromuscular/home.html (800) 605-8787

 U Missouri-Johnson Lab: http://www.caninegeneticdiseases.net/ (573)-884-3712)

 Univ. New South Wales-Wilton Lab: ma.wilton@unsw.edu.au

 VetGen: http://www.vetgen.com (800-483-8436)

 Washington State U-Meurs Lab: http://www.vetmed.wsu.edu/deptsVCGL/ (509-335-6038)

 Washington State U-Pharm Lab: http://www.vetmed.wsu.edu/depts-VCPL/ (509-335-3745)

 

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

Jerold S. Bell, DVM
Tufts Cummings School of Veterinary Medicine
N. Grafton, MA, USA


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